Search
Now showing items 31-40 of 54
Vector prevalence and detection of crimean-congo haemorrhagic fever virus in Golestan province, Iran
(2017-12)
Background & Objectives: Crimean-Congo haemorrhagic fever virus (CCHFV) causes severe disease with fatality rate of 30%. The virus is transmitted to humans through the bite of an infected tick, direct contact with the ...
Mutations in RAB39B in individuals with intellectual disability, autism spectrum disorder, and macrocephaly
(2017-11-09)
Background:
Autism spectrum disorder (ASD), a developmental disorder of early childhood onset, affects males four times more frequently than females, suggesting a role for the sex chromosomes. In this study, we describe ...
Variable phenotype expression in a family segregating microdeletions of the NRXN1 and MBD5 autism spectrum disorder susceptibility genes
(2017-05-03)
Abstract:
Autism spectrum disorder is a developmental condition of early childhood onset, which impacts socio-communicative functioning and is principally genetic in etiology. Currently, more than 50 genomic loci are ...
Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer
(2017-05-11)
Abstract:
Serum from one hundred and ten breast cancer patients and thirty healthy female volunteers, were prospectively collected and evaluated for serum levels of Shh and IL-6 using human Shh and IL-6 specific enzyme-linked ...
Nootkatone confers hepatoprotective and anti-fibrotic actions in amurine model of liver fibrosis by suppressing oxidative stress, inflammation, and apoptosis
(2017-11-20)
Abstract:
In this study, the hepatoprotective and anti-fibrotic actions of nootkatone (NTK) were investigated using carbon tetrachloride (CCl4)-induced liver fibrosis in mice. CCl4 administration elevated serum aspartate ...
Muscle sympathetic nerve activity peaks in the first trimester in healthy pregnancy: a longitudinal case study
(2017-07-03)
Objective and methods:
Muscle sympathetic nerve activity and baroreflex sensitivity were examined at rest before, during (weeks 6, 11, 17, 22, 25, 33 and 36) and after a normotensive pregnancy.
Results:
Muscle sympathetic ...
Epithelial Mesenchymal Transition (EMT) in Metastatic Breast Cancer in Omani Women
(2017-05-19)
Abstract:
Breast cancer (BC) in Oman affects younger women and has a more aggressive course. Clinical and biological variables like age, pregnancy, tumor size, type, grade, receptor expression and proliferation predict ...
A Highly Durable RNAi Therapeutic Inhibitor of PCSK9
(2017)
To the Editor:
The study by Fitzgerald et al. poses the question as to whether inclisiran is suitable for long-term treatment of hyperlipidemia. In contrast with PCSK9 antibodies, which target plasma PCSK9, inclisiran ...
Counterfeit and substandard drugs in Sub-Saharan Africa may pose a major hurdle to H3Africa’s initiative to study genetics of kidney disease progression
(2017)
To the Editor:
The Human Heredity and Health in Africa Kidney Disease Research Network aims to investigate the genetics of renal disease progression.1 Diabetes mellitus and hypertension have emerged as the commonest ...
Role of flavonoids in thrombotic, cardiovascular, and inflammatory diseases
(2017)
Abstract:
The failure of mechanisms of natural anti-coagulation either due to genetic impairment or due to severe external injuries may result in a condition called thrombosis. This is believed to be the primary cause for ...