MBRU Knowledge Repository
Knowledge Repository at Mohammed Bin Rashid University of Medicine and Health Sciences
Welcome to digital archive and research repository of Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU). MBRU Knowledge Repository is a digital service that collects, preserves, and distributes digital material. MBRU's scholarly communications including theses, faculty publications, student projects, and departmental records and publications are the key digital records available in this repository. Repositories are important tools for preserving an organization's legacy; they facilitate digital preservation and scholarly communication.
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- Research and Scholarly work of College of Medicine
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- Research and Scholarly work of Graduate Medical Education
- Research and Scholarly work of Hamdan Bin Mohammed College of Dental Medicine
- Research and Scholarly work of Hind Bint Maktoum College of Nursing and Midwifery
- Research and Scholarly work of IoL
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- Theses and dissertations submitted by MBRU graduate and post-graduate students.
Recent Submissions
Clinical and Radiographic Evaluation of Bone Profile Around Dental Implants Placed in the Esthetic Zone
(Informa UK Limited, 2025-02) Allam, Eman
Objective: To evaluate the bone profile around dental implants placed in the esthetic zone through periodontal assessment and radiographic analysis using cone-beam computed tomography (CBCT).
Methods: We conducted a clinical observational study of 35 subjects who received dental implants placed in the esthetic zone to replace lost anterior teeth. Clinical evaluation included a comprehensive periodontal examination. The esthetic outcomes of the soft tissue around the implants were assessed using the pink esthetic score (PES). Patient satisfaction was assessed by using a specially designed questionnaire. The Oral Health Impact Profile (OHIP)-14 was used to assess the quality of life. The bone profile around the implant was assessed using CBCT. All the values were compared and statistically analyzed.
Results: A soft tissue graft (STG) was associated with the presence of > 2 mm of bone thickness 1 mm from the implant shoulder (p < 0.01). The STG was also significantly associated with bone thickness at 3 and 5 mm (p = 0.04). PES was not significantly associated with the bone thickness, OHIP score, or satisfaction score. Patients with fenestrations had significantly higher scores for functional limitations and pain than those without fenestrations (p = 0.01 and 0.04 respectively).
Conclusion: The bone profile around the anterior implant is not ideal. Although the buccal bone was thin around the implant placed in the esthetic zone, it did not affect the esthetic outcomes or overall satisfaction of the patient. However, fenestration defects may affect patients' quality of life.
The effects of Lepidium meyenii on MSG-induced subfertility in male Wistar rats: Targeting oxidative stress, pro-inflammatory cytokines, steroidogenic enzymes, and reproductive hormones regulation
(Elsevier BV, 2025-01) Omolaoye, Temidayo S.; Rawat, Surendra Singh; Plessis, Stefan S. Du
Objective and rationale: Although monosodium glutamate (MSG), commonly used to enrich food flavour, is generally considered safe for consumption, evidence has shown its adverse effects on physiological functions, including male reproduction, when consumed excessively. Lepidium meyenii (Maca), on the other hand, a plant belonging to the Brassicaceae family, has been shown to have diverse health benefits. The current study investigated pathways through which MSG could induce subfertility, and whether treatment with Maca root extract would proffer amelioration via those routes.
Methods: Eighteen male Wistar rats were randomly divided into three groups. Animals were orally (oral gavage) administered MSG (900 mg/kg/day for 45days), MSG and Maca (900 mg/kg/day of MSG and 500 mg/kg/day of black Lepidium meyenii root extract), or water only (control group), for a total period of 80 days. MSG was administered for the first 45 days, followed by Maca or water for the subsequent 35 days. Spermatozoa were collected from the caudal epididymis for sperm assessments. The testis and prostate were used for biochemical assays and immunofluorescent localization of biomarkers of interest.
Results: MSG administration significantly reduced total and progressive sperm motility (p < 0.05), decreased total antioxidant capacity (TAC) (p < 0.001), increased mRNA expression of TNF-α, IL-6, IL-1β in the testis and prostate (p < 0.05), protein expression of GP130 in the testis, reduced serum testosterone, and altered expression of steroidogenic markers. These adverse effects were mildly ameliorated upon treatment with Maca.
Conclusion: Findings highlights how MSG could cause male reproductive dysfunction via reduction of TAC, increase in pro-inflammatory cytokines, alter reproductive hormones and reduced protein expression of steroidogenic markers. Treatment with Maca significantly improved sperm motility, possibly by enhancing TAC levels and reducing proinflammatory cytokines. However, this hypothesis needs further investigation.
The relationship between malocclusion and speech patterns: a cross-sectional study
(Springer Science and Business Media LLC, 2025-01-14) Allam, Eman
Objective: Dental occlusion and the alignment of the dentition play crucial roles in producing speech sounds. The Arabic language is specifically complex, with many varieties and geographically dependent dialects. This study investigated the relationship between malocclusion and speech abnormalities in the form of misarticulations of Arabic sounds.
Materials and methods: One hundred native subjects (28.92 ± 12.09 years old) were recruited for this cross-sectional study. The Peer Assessment Rating (PAR) index was used to describe malocclusion pattern. A standard speech sample was recorded for each subject and evaluated by a blinded speech therapist to judge misarticulations and indicate the misarticulation classification. The Jeddah Institute for Speech and Hearing Centre (JISH) articulation test was used to assess the phonologic abilities of the participants. Mann-Whitney U test was utilized for the statistical analysis. P-value < 0.05 was considered statistically significant.
Results: The PAR score ranged from 0 to 15, with an average of 4.87. The descriptive statistics of the included sample demonstrated that twenty-seven subjects showed improper articulation of sounds, with 25 being distortions and 2 substitutions. No significant gender differences were reported. A statistically significant association between PAR scores was recorded for the sounds / ص/ (p = 0.004), / ز/ (p = 0.017), and / س/ (p = 0.010).
Conclusions: There was an evident pattern of partial association of PAR index scores and speech abnormalities including improper articulation. To provide optimal care for involved subjects, collaboration between orthodontists and speech therapists, in pre- and post-treatment evaluations, is crucial.
The Expression of HIF-1α and VEGF in Radicular Cysts and Periapical Granulomas
(Georg Thieme Verlag KG, 2024-12-10) Rawat, Surendra Singh
Objectives: This study aimed to evaluate the expression levels of hypoxia-inducible factor 1-α (HIF-1α) and vascular endothelial growth factor (VEGF) in radicular cysts and periapical granulomas, thereby contributing to the understanding of their potential significance in the differential diagnosis and treatment of these lesions.
Materials and methods: In the present cross-sectional study, 51 samples of periapical lesions were included. Of them, 24 samples were radicular cysts, and 27 samples were periapical granulomas. Samples were immunohistochemically analyzed for HIF-1α and VEGF proteins expression. Chi-square tests and Spearman's rank correlation coefficient tests were used to detect differences and correlations among the parameters, respectively.
Results: In radicular cysts, HIF-1α expression was absent in 1 (4.2%), weak in 5 (20.8%), mild in 7 (29.2%), and strong in 11 (45.8%) cases, while VEGF expression was absent in 1 (4.2%), weak in 6 (25.0%), mild in 9 (37.5%), and strong in 8 (33.3%) of the cases; nevertheless, in periapical granulomas, HIF-1α expression was absent in 8 (29.6%), weak in 6 (22.2%), mild in 9 (33.3%), and strong in 4 (14.8%) of the cases, whereas VEGF expression was absent in 4 (14.8%), weak in 16 (59.3%), mild in 4 (14.8%), and strong in 3 (11.1%) of the cases. Chi-square test revealed a significant difference in the expression of HIF-1α and VEGF between radicular cysts and periapical granuloma (chi-square test = 8.906, p = 0.031; chi-square test = 10.401, p = 0.015, respectively). Spearman's correlation test showed a significant correlation between HIF-1α and VEGF in the total samples of both radicular cysts and periapical granulomas (rho = 0.385, p = 0.005).
Conclusion: There is high expression of both HIF-1α and VEGF throughout the odontogenic epithelium and connective tissue of the radicular cyst and periapical granuloma. Both HIF-1α and VEGF are more highly expressed in radicular cysts than in periapical granulomas. These findings may aid in the diagnosis and management of suspected periapical lesions, suggesting that radicular cysts exhibit more advanced hypoxic conditions and associated pathways compared with periapical granulomas.
Retinal blood vessel diameter changes with 60-day head-down bedrest are unaffected by antioxidant nutritional cocktail.
(2024-11-15) Goswami, Nandu
Long-term human spaceflight can lead to cardiovascular deconditioning, but little is known about how weightlessness affects microcirculation. In this study, we examined how the retinal microvessels and cerebrovascular regulation of 19 healthy male participants responded to long-term head-down bedrest (HDBR), an earth-based analog for weightlessness. In addition, we examined whether an anti-inflammatory/antioxidant cocktail could prevent the vascular changes caused by HDBR. In all study participants, we found a decrease in retinal arteriolar diameter by HDBR day 8 and an increase in retinal venular diameter by HDBR day 16. Concurrently, blood pressure at the level of the middle cerebral artery and the cerebrovascular resistance index were higher during HDBR, while cerebral blood flow velocity was lower. None of these changes were reversed in participants receiving the anti-inflammatory/antioxidant cocktail, indicating that this cocktail was insufficient to restore the microvascular and cerebral blood flow changes induced by HDBR.