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1,2,3-Triazolyl ester of ketorolac (15K), a potent PAK1 blocker, inhibits both growth and metastasis of orthotopic human pancreatic cancer xenografts in mice
(2019)More than 90% of human pancreatic cancers carry the oncogenic mutant of Ki-RAS and their growth depends on its downstream kinase PAK1, mainly because PAK1 blocks the apoptosis of cancer cells selectively. We developed a ... -
2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales
(2020)Abstract: In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. At the genus rank, 20 new ... -
Action of 1,25(OH)2D3 on Human Asthmatic Bronchial Fibroblasts: Implications for Airway Remodeling in Asthma
(2020)Background: Airway fibroblasts are major contributors to the histopathological feature of airway remodeling in asthma by their implication in the cell invasiveness and profibrogenic secretory phenotype observed in ... -
Acute cardiac injury is associated with adverse outcomes, including mortality in COVID-19 patients
(2020)Abstract: Objectives: To evaluate acute cardiac injury in COVID-19 patients and its association with adverse outcomes including mortality in the United Arab Emirates (UAE) population. Methods: A retrospective study ... -
Acute heart failure presentations and outcomes during the fasting month of Ramadan: an observational report from seven Middle Eastern countries
(2018)Background: Fasting during the month of Ramadan is practiced by over 1.5 billion Muslims worldwide. It remains unclear, however, how this change in lifestyle affects heart failure, a condition that has reached epidemic ... -
Adoption of the ADA/EASD guidelines in 10 Eastern and Southern European countries: Physician survey and good clinical practice recommendations from an international expert panel
(2020)Abstract: The aim of the present study was to assess the adoption of the ADA/EASD guidelines in a convenience sample of physicians from Eastern and Southern Europe, the barriers to the implementation of these guidelines ... -
AFM-compatible microfluidic platform for affinity-based capture and nanomechanical characterization of circulating tumor cells
(2020)Abstract: Circulating tumor cells (CTCs) carried by the patient’s bloodstream are known to lead to the metastatic spread of cancer. It is becoming increasingly clear that an understanding of the nanomechanical characteristics ... -
Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD
(2020)Abstract: It has been reported that angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are the main cell entry proteins for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and ... -
Analysis of blood donor pre-donation deferral in Dubai: Characteristics and reasons
(2017)Background: To ensure an adequate and safe blood supply, it is crucial to select suitable donors according to stringent eligibility criteria. Understanding the reasons for donor deferral can help in planning more efficient ... -
Analysis of risk factors, presentation, and in-hospital events of very young patients presenting with ST-elevation myocardial infarction
(2017-02-05)Introduction: In the Indian subcontinent and Arab Gulf, coronary artery disease is affecting younger persons at greater rates. Few studies have focused on young ST-elevation myocardial infarction (STEMI) patients in these ... -
An anatomical investigation of the carotid canal
(2017)Background: The carotid canal (CC) located in the petrous temporal bone trans-mits the internal carotid artery, internal carotid venous plexus and sympathetic nerve plexus from the neck into the cranial cavity. It is an ... -
An ANKRD26 nonsense somatic mutation in a female with epidermodysplasia verruciformis (Tree Man Syndrome)
(2018-04-26)Abstract: Epidermodysplasia verruciformis (EV) is an extremely rare hereditary skin disease characterized by an abnormal susceptibility to the human papilloma virus (HPV) with an increased risk of cutaneous malignancy. ... -
Antenatal Care Initiation Among Pregnant Women in the United Arab Emirates: The Mutaba'ah Study
(2020)Introduction: Antenatal care (ANC) provides monitoring and regular follow-up of maternal and fetal health during pregnancy. Women with appropriate ANC tend to have better delivery and birth outcomes. This study describes ... -
Anterior teeth root inclination prediction derived from digital models: A comparative study of plaster study casts and CBCT images Mahmoud Dastoori MSc, University College London, 2007 DDS, Ajman
(2017-08)Aim: To assess the accuracy of digital models generated using commercially available software to predict anterior teeth root inclination characteristics and compare the results to relevant data obtained from CBCT images. ... -
Anterior teeth root morphology prediction as derived from digital models: A comparative study of plaster study casts and natural teeth from dry skulls
(2018)Aim: To assess the accuracy and reliability of the digital images of dental models generated by specific commercially available software in predicting root morphology characteristics in comparison to the corresponding ... -
An anthropometric evaluation of the scapula, with emphasis on the coracoid process and glenoid fossa in a South African population
(2019)Abstract: The exact dimensions of the scapula, including the coracoid process and glenoid fossa, are fundamental in the patho-mechanics of the glenohumeral joint (GHJ); as these structures act as initiators of shoulder ... -
Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1
(2019-05-10)Background: A newly developed drug trastuzumab emtansine (T-DM1) has improved the survival of breast cancer (BC) patients. Despite an impressive initial clinical response, a subgroup of patient develop resistance and ... -
Applications and Challenges of Implementing Artificial Intelligencein Medical Education: Integrative Review
(2019-05)Background: Since the advent of artificial intelligence (AI) in 1955, the applications of AI have increased over the years within a rapidly changing digital landscape where public expectations are on the rise, fed by ... -
Are asthma and airway allergy associated with increased root resorption following orthodontic treatment? A systematic review
(2020)Aim: Asthma and airway allergy have been implicated with root resorption development following orthodontic treatment. The objective of this study was to investigate systematically the relevant literature. Materials ... -
An arthroscopic evaluation of the anatomical “critical zone”
(2017)Background: The “critical zone”, a region of speculated vascularity, is situated approximately 10 mm proximal to the insertion of the supraspinatus tendon. De-spite its obvious role as an anatomical landmark demarcator, ...