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Now showing items 171-178 of 178
UMP-CMP kinase 2 gene expression in macrophages is dependent on the IRF3-IFNAR signaling axis
(2021)
Abstract:
Toll-like receptors (TLRs) are highly-conserved pattern recognition receptors that mediate innate immune responses to invading pathogens and endogenous danger signals released from damaged and dying cells. ...
Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19
(2021)
Summary:
Understanding host cell heterogeneity is critical for unraveling disease mechanism. Utilizing large-scale single-cell transcriptomics, we analyzed multiple tissue specimens from patients with life-threatening ...
A modular map of Bradykinin‑mediated inflammatory signaling network
(2021)
Abstract:
Bradykinin, a member of the kallikrein-kinin system (KKS), is associated with an inflammatory response pathway with diverse vascular permeability functions, including thrombosis and blood coagulation. In majority, ...
Educating the next generation, is every case a case for training?
(2021)
Summary:
Current elective waiting lists are in crisis due to a combination of reduced access to surgery during the start of the pandemic and further COVID waves adding to the pressure on beds necessary for elective inpatient ...
Clinical and Laboratory Profile of Hospitalized Symptomatic COVID-19 Patients: Case Series Study From the First COVID-19 Center in the UAE
(2021)
Introduction:
COVID-19 is raising with a second wave threatening many countries. Therefore, it is important to understand COVID-19 characteristics across different countries.
Methods:
This is a cross-sectional descriptive ...
Differential expression of pyruvate dehydrogenase E1A and its inactive phosphorylated form among breast cancer subtypes
(2021)
Aims:
Pyruvate dehydrogenase E1A (PDH-E1A) is one of the key regulators of metabolic pathways that determines pyruvate entry into the citric acid cycle or glycolysis. When PDH-E1A is phosphorylated (P-PDH-E1A), it loses ...
Coinfections in Patients Hospitalized with COVID-19: A Descriptive Study from the United Arab Emirates
(2021)
Purpose:
Microbial coinfections in COVID-19 patients carry a risk of poor outcomes. This study aimed to characterize the clinical and microbiological profiles of coinfections in patients with COVID-19.
Methods:
A ...
Use of simulation in teaching haematological aspects to undergraduate medical students improves student’s knowledge related to the taught theoretical underpinnings
(2021)
Background:
Simulation is an educational method which has several modalities and applications. In the last few decades Simulation-Based Medical Education (SBME) has become a significant influence in medical education. ...