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    Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19

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    204-2021.174 Nasna Nassir.pdf (2.743Mb)
    Date
    2021
    Author
    Nassir, Nasna
    Tambi, Richa
    Bankapur, Asma
    Al Heialy, Saba
    Karuvantevida, Noushad
    Zehra, Binte
    Begum, Ghausia
    Hameid, Reem Abdel
    Ahmed, Awab
    Shabestari, Seyed Ali Safizadeh
    Kandasamy, Richard Kumaran
    Loney, Tom
    Tayoun, Ahmad Abou
    Nowotny, Norbert
    Hachim, Mahmood Yaseen
    Berdiev, Bakhrom K.
    Alsheikh-Ali, Alawi
    Uddin, Mohammed
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    Abstract
    Summary: Understanding host cell heterogeneity is critical for unraveling disease mechanism. Utilizing large-scale single-cell transcriptomics, we analyzed multiple tissue specimens from patients with life-threatening COVID-19 pneumonia, compared with healthy controls. We identified a subtype of monocyte-derived alveolar macrophages (MoAMs) where genes associated with severe COVID-19 comorbidities are significantly upregulated in bronchoalveolar lavage fluid of critical cases. FCGR3B consistently demarcated MoAM subset in different samples from severe COVID-19 cohorts and in CCL3L1-upregulated cells from nasopharyngeal swabs. In silico findings were validated by upregulation of FCGR3B in nasopharyngeal swabs of severe ICU COVID-19 cases, particularly in older patients and those with comorbidities. Additional lines of evidence from transcriptomic data and in vivo of severe COVID-19 cases suggest that FCGR3B may identify a specific subtype of MoAM in patients with severe COVID-19 that may present a novel biomarker for screening and prognosis, as well as a potential therapeutic target.
    URI
    https://repository.mbru.ac.ae/handle/1/916
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