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A Highly Durable RNAi Therapeutic Inhibitor of PCSK9
(2017)To the Editor: The study by Fitzgerald et al. poses the question as to whether inclisiran is suitable for long-term treatment of hyperlipidemia. In contrast with PCSK9 antibodies, which target plasma PCSK9, inclisiran ... -
Host transcriptomic profiling of COVID-19 patients with mild, moderate, and severe clinical outcomes
(2021)Abstract: Characterizing key molecular and cellular pathways involved in COVID-19 is essential for disease prognosis and management. We perform shotgun transcriptome sequencing of human RNA obtained from nasopharyngeal ... -
How decisive is the number of distal arterial anastomoses in coronary bypass surgery?
(2021)Background: The benefit of arterial revascularization in coronary surgery remains controversial. The incremental value of additional grafts to the left internal thoracic artery (ITA) has been mainly assessed according ... -
How Do Schoolchildren View Other Children Who Have Discolored Teeth?
(2021)Objectives: Facial look and expression affect how people are viewed by others. This study aimed to evaluate how schoolchildren in the Emirate of Sharjah, United Arab Emirates view their peers who have discolored teeth. ... -
How do we strengthen the health workforce in a rapidly developing high-income country? A case study of Abu Dhabi's health system in the United Arab Emirates
(2019-01)Background: The United Arab Emirates (UAE) is a rapidly developing high-income country that was formed from the union of seven emirates in 1971. The UAE has experienced unprecedented population growth coupled with increased ... -
How does allergen sensitization affect orthodontic tooth movement associated phenomena? A systematic review of animal studies
(2022)Background: The immunologic reaction of chronically allergic and asthmatic patients is characterized by systemic imbalances, resulting in an upregulation of mediators that might also be involved in bone remodeling during ... -
How orthodontic research can be enriched and advanced by the novel and promising evolutions in biomedicine
(2021)Abstract: Recent advances in developmental, molecular and cellular biology as well as biomedical technologies show a promising future for crossing the gap between biomedical basic sciences and clinical orthodontics. ... -
Human Dorsal Root Ganglion Stimulation Reduces Sympathetic Outflow and Long-Term Blood Pressure
(2020)Summary: This study hypothesized that dorsal root ganglion (DRG) stimulation would reduce sympathetic nerve activity and would alter hemodynamic variables. This study directly recorded muscle sympathetic nerve activity ... -
Human gingival fibroblasts: Isolation, characterization, and evaluation of CD146 expression
(2021)Abstract: Gingival fibroblasts (GFs) that exhibit adult stem cell-like characteristics are known as gingival mesenchymal stem cells (GMSCs). Specific mesenchymal stem cell (MSC) markers have not been identified to ... -
Human physiology adaptation to altered gravity environments
(2021)Abstract: Multiple transitions between gravity levels will occur during planetary exploration missions. In reaction to these gravitational transitions, physiological adaptation will be initiated. However, the physiological ... -
Hybrid child friendly biological primary molar restorative alternatives to general anaesthesia
(2018-09)Abstract: Management of early childhood caries, especially in high caries prevalence regions, is challenging, with multiple extractions under general anaesthesia (GA) becoming frequently unavoidable. This paper describes ... -
A hypertension risk score for adults: a population-based cross-sectional study from the Dubai Household Survey 2019
(2021)Objectives: The aim of this study was to develop a risk score model for predicting hypertension specific to the population of Dubai in the United Arab Emirates (UAE) to facilitate prevention and early intervention. Methods: A ... -
“I Must Try Harder”: Design Implications for Mobile Apps and Wearables Contributing to Self-Efficacy of Patients With Chronic Conditions
(2019)Background: Diverse wellness-promoting mobile health technologies, including mobile apps and wearable trackers, became increasingly popular due to their ability to support patients’ self-management of health conditions. ... -
Iatrogenic (Traumatic) Occipital Artery Pseudoaneurysm – Rare Complication of Ventriculoperitoneal Shunt in an Infant: Case Report and Review of the Literature
(2018)Abstract: Although ventriculoperitoneal shunt (VPS) is the most common procedure performed by pediatric neurosurgeons, it is still associated with frustrating complications, most common of which are obstruction and ... -
ICTV Virus Taxonomy Profile: Bornaviridae
(2021)Abstract: Members of the family Bornaviridae produce enveloped virions containing a linear negative-sense non-segmented RNA genome of about 9 kb. Bornaviruses are found in mammals, birds, reptiles and fish. The most-studied ... -
Identification of Breast Cancer LCK Proto-Oncogene as a Master Regulator of TNBC Neutrophil Enrichment and Polarization
(2023)Abstract: The role of neutrophils in breast cancer shows that the N1 proinflammatory subtype can suppress and attack the tumor. In contrast, the N2 pro-tumor subtype aids the tumor in its survival, progression, and ... -
Identification of early indicators of altered metabolism in normal development using a rodent model system
(2018-03-01)Abstract: Although the existence of a close relationship between the early maternal developmental environment, fetal size at birth and the risk of developing disease in adulthood has been suggested, most studies,however, ... -
Identification of Key Factors for Optimized Healthcare Services: A Protocol for a Multi-phase Study of the Dubai Vaccination Campaign
(2022)Background: Mass vaccination of the global population against the novel coronavirus (COVID-19) posed multiple challenges, including effectively administering millions of doses in a short period of time while ensuring ... -
Identification of Predictive Biomarkers for Lymph Node Involvement in Obese Women With Endometrial Cancer
(2021)Abstract: Obesity, an established risk factor for endometrial cancer (EC), is also associated to increased risks of intraoperative and postoperative complications. A reliable tool to identify patients at low risk for lymph ... -
Identification of public health priorities, barriers, and solutions for Kuwait using the modified Delphi method for stakeholder consensus
(2021)Abstract: The rapid modernization and economic developments in Kuwait, have been accompanied by substantial lifestyle changes such as unhealthy diet and physical inactivity. These modifiable behaviours have contributed ...