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Now showing items 768-787 of 1430
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Lack of ethnic diversity in single-cell transcriptomics hinders cell type detection and precision medicine inclusivity
(2023)Abstract: Perhaps one of the most revolutionary next generation sequencing technologies is single-cell (SC) transcriptomics, which was recognized by Nature in 2013 as the method of the year. SC-technologies delve deep ... -
Laparoscopic uretero-ileal substitution preserving the natural anti-reflux mechanism: A case report
(2023)Abstract: Ureteral strictures constitute one of the most common sequelae of impacted ureteral stones. Uretero-ileal substitution is an established treatment for long benign ureteral strictures, measuring more than 2 cm, ... -
Large-scale all-atom molecular dynamics alanine-scanning of IAPP octapeptides provides insights into the molecular determinants of amyloidogenicity
(2019-02-21)Abstract: In order to investigate the early phase of the amyloid formation by the short amyloidogenic octapeptide sequence (‘NFGAILSS’) derived from IAPP, we carried out a 100ns all-atom molecular dynamics (MD) simulations ... -
Late presentation of extrauterine adenomyomas after laparoscopic morcellation at hysterectomy: a case report
(2021)Background: An adenomyoma is a well circumscribed form of adenomyosis and can be located within the myometrium, in the endometrium as a polyp, or extrauterine with the last being the rarest presentation amongst the three. ... -
Lateral Flow Immunoassay for the Detection of Panton-Valentine Leukocidin in Staphylococcus aureus From Skin and Soft Tissue Infections in the United Arab Emirates
(2021)Introduction: Panton Valentine leukocidin (PVL) is a virulence factor which is associated with methicillin sensitive and resistant Staphylococcus aureus (MSSA/MRSA) causing skin and soft tissue infections (SSTI). This ... -
Lateral Wall Regeneration and Membrane Repair After Attempted Sinus Augmentation Using a Non-Resorbable Membrane
(2017)Abstract: Insufficient bone height for dental implant placement is often encountered in the posterior maxilla. Its main causes are postextraction alveolar ridge resorption and increased maxillary sinus size due to the ... -
Learning from the law. A review of 21 years of litigation for nerve injury following central neuraxial blockade in obstetrics
(2019)Abstract: Medicolegal claims for neurological injury following the use of central neuraxial blockade in childbirth represent the second most common claim against obstetric anaesthetists. We present an analysis of 55 cases ... -
Learning from the Law. A review of 21 years of litigation for pain during caesarean section
(2018)Abstract: The large majority of caesarean sections in the UK are now carried out under neuraxial anaesthesia. Although this technique is widely accepted as being the safest option in most circumstances, the use of regional ... -
The legal framework and initiatives for promoting safety in the United Arab Emirates
(2012)Introduction: Injury is a leading cause of morbidity and mortality in the United Arab Emirates (UAE). The UAE is a rapidly developing country with fast economic growth, demographical and environmental changes that are ... -
Leptin, insulin like growth factor-I levels and histology-diagnosed placental malaria in an area characterized by unstable malaria transmission in central Sudan
(2017)Background: There are few published data on the association between leptin, insulin like growth factor-1 (IGF-1) and malaria during pregnancy. This study aimed to investigate maternal and umbilical cord leptin and IGF-1 ... -
Leveraging the Added Value of Experiential Co-Curricular Programs to Humanize Medical Education
(2021)Background: The aftermath of the 1910 Flexner report resulted in significant gaps in the structure of medical education. Experiential co-curricular opportunities can contribute to addressing these gaps. Purpose: To ... -
Ligament Tissue Engineering: The Anterior Cruciate Ligament
(2021)Abstract: Due to ongoing problems with reconstructive surgery and recent advancements in the field of musculoskeletal tissue engineering, regeneration of ligaments in general and of the anterior cruciate ligament (ACL) ... -
Lipids derived from Camel milk regulate NLRP3 inflammasome subunit-dependent inflammatory responses in human macrophages
(2021)Background: Camel milk is widely used for its reported anti-diabetic and health promoting effects. Lipids derived from the milk have also been shown to exhibit potent anti-inflammatory effects. The mechanism through which ... -
Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification
(2017-03-30)Abstract: Lipoprotein(a), or Lp(a), significantly increased alkaline phosphatase activity, release of phosphate, calcium deposition, hydroxyapatite, cell apoptosis, matrix vesicle formation, and phosphorylation of signal ... -
Liraglutide Increases Serum Levels of MicroRNA-27b, -130a and -210 in Patients with Type 2 Diabetes Mellitus: A Novel Epigenetic E ect
(2020)Abstract: Liraglutide has shown favourable e_ects on several cardiometabolic risk factors, beyond glucose control. MicroRNAs (miRNAs) regulate gene expression, resulting in post-transcriptional modifications of cell ... -
A literature review and best practice advice for second and third trimester risk stratification, monitoring, and management of pre-eclampsia
(2021)Abstract: Pre-eclampsia is a multisystem disorder that typically affects 2%–5% of pregnant women and is one of the leading causes of maternal and perinatal morbidity and mortality, especially when the condition is of early ... -
Living Books: A Community Engagement Event to Encourage Open & Real Conversation
(2019-11)Inspired by Human Library which is designed to build a positive framework for conversations that can challenge stereotypes and prejudices through dialogue. Al Maktoum Medical Library designed a similar framework where ... -
LncRNA-Associated Genetic Etiologies Are Shared between Type 2 Diabetes and Cancers in the UAE Population
(2022)Abstract: Numerous epidemiological studies place patients with T2D at a higher risk for cancer. Many risk factors, such as obesity, ageing, poor diet and low physical activity, are shared between T2D and cancer; however, ... -
Long head of biceps brachii tendon and transverse humeral ligament morphometry and their associated pathology
(2020)Background: As a dynamic stabiliser and flexor of the glenohumeral joint, the long head of the biceps brachii tendon (LHBBT) is further stabilised by the retinacular activities of the transverse humeral ligament ... -
Long-Read Sequencing Improves the Detection of Structural Variations Impacting Complex Non-Coding Elements of the Genome
(2021)Abstract: The advent of long-read sequencing offers a new assessment method of detecting genomic structural variation (SV) in numerous rare genetic diseases. For autism spectrum disorders (ASD) cases where pathogenic ...
