Browsing by Title
Now showing items 54-73 of 1358
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Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1
(2019-05-10)Background: A newly developed drug trastuzumab emtansine (T-DM1) has improved the survival of breast cancer (BC) patients. Despite an impressive initial clinical response, a subgroup of patient develop resistance and ... -
Antimicrobial Activity of Phytic Acid: An Emerging Agent in Endodontics
(2021)Background: Phytic acid (IP6) is a promising and emerging agent, and because of its unique structure and distinctive properties, it lends itself to several applications in dentistry. Recently, IP6 was proposed as a potential ... -
Anti‑Balamuthia mandrillaris and anti‑Naegleria fowleri efects of drugs conjugated with various nanostructures
(2023)Abstract: Balamuthia mandrillaris and Naegleria fowleri are protist pathogens that can cause fatal infections. Despite mortality rate of>90%, there is no effective therapy. Treatment remains problematic involving repurposed ... -
Apical root resorption of deciduous teeth: a review
(2016)Abstract: The resorption of deciduous teeth is considered a necessary process leading to their exfoliation. In most cases it begins in the apical root region and proceeds coronally, yet some local or systemic factors can ... -
Appendectomy as part of Ladd’s procedure: a systematic review and survey analysis
(2023)Background: Ladd’s Procedure has been the surgical intervention of choice in the management of congenital intestinal malrotation for the past century. Historically, the procedure included performing an appendectomy to ... -
Application of Artificial Intelligence in Combating High Antimicrobial Resistance Rates
(2022)Abstract: Artificial intelligence (AI) is a branch of science and engineering that focuses on the computational understanding of intelligent behavior. Many human professions, including clinical diagnosis and prognosis, ... -
Application of CRISPR-Cas System to Mitigate Superbug Infections
(2023)Abstract: Multidrug resistance in bacterial strains known as superbugs is estimated to cause fatal infections worldwide. Migration and urbanization have resulted in overcrowding and inadequate sanitation, contributing to ... -
Application of microneedle patches for drug delivery; doorstep to novel therapies
(2022-03)Abstract: In the past decade, microneedle-based drug delivery systems showed promising approaches to become suitable and alternative for hypodermic injections and can control agent delivery without side effects compared ... -
Applications and Challenges of Implementing Artificial Intelligencein Medical Education: Integrative Review
(2019-05)Background: Since the advent of artificial intelligence (AI) in 1955, the applications of AI have increased over the years within a rapidly changing digital landscape where public expectations are on the rise, fed by ... -
Applying the COM-B behaviour model to understand factors which impact school immunisation nurses attitudes towards designing and delivering a HPV educational intervention in post-primary schools for 15–17 year old students in Northern Ireland, UK
(2023)Introduction: Human Papilloma Virus (HPV) is responsible for the development of cervical, vaginal, vulvar, penile, oropharyngeal and anal cancers. Throughout the UK, Immunisation nurses (IMNs) deliver school-based HPV ... -
Approach to Endoscopic Balloon Dilatation in Pediatric Stricturing Crohn Disease: A Position Paper of the Endoscopy Special Interest Group of ESPGHAN
(2023)Abstract: Crohn disease (CD) is often complicated by bowel strictures that can lead to obstructive symptoms, resistant inflammation, and penetrating complications. Endoscopic balloon dilatation of CD strictures has emerged ... -
Are asthma and airway allergy associated with increased root resorption following orthodontic treatment? A systematic review
(2020)Aim: Asthma and airway allergy have been implicated with root resorption development following orthodontic treatment. The objective of this study was to investigate systematically the relevant literature. Materials ... -
Are asthma and allergy associated with increased root resorption following orthodontic treatment? A meta-analysis
(2023)Objective: The aim of this study is to systematically investigate the available evidence from human studies regarding the association of asthma and/or allergy with EARR. Materials and methods: Unrestricted searches ... -
Are orthodontic landmarks and variables in digital cephalometric radiography taken in fixed and natural head positions reliable?
(2020)Objective: The purpose of the study was to evaluate the reliability of the most common landmarks and variables in digital lateral cephalometric radiographies in fixed and natural head positions. Materials and methods: ... -
Arterial Stiffness in a Cohort of Young People Living With Perinatal HIV and HIV Negative Young People in England
(2022)Background: Antiretroviral therapy (ART) has increased life expectancy and consequently the risk of cardiovascular disease (CVD) in adults living with HIV. We investigated the levels and predictors of arterial stiffness ... -
An arthroscopic evaluation of the anatomical “critical zone”
(2017)Background: The “critical zone”, a region of speculated vascularity, is situated approximately 10 mm proximal to the insertion of the supraspinatus tendon. De-spite its obvious role as an anatomical landmark demarcator, ... -
Arthroscopic Treatment of Pigmented Villonodular Synovitis of the Elbow
(2022)Abstract: Pigmented villonodular synovitis (PVNS) is a benign proliferative disorder of synovium that surrounds the joints, tendon sheaths, and bursae. The elbow is rarely affected, making it difficult to establish treatment ... -
Artificial intelligence for precision medicine in neurodevelopmental disorders
(2019)Abstract: The ambition of precision medicine is to design and optimize the pathway for diagnosis, therapeutic intervention, and prognosis by using large multidimensional biological datasets that capture individual variability ... -
Assessing clinical outcomes of modified laparoscopic gastrostomy in children: a case control study
(2022)Background: With gastrostomy becoming a common surgical procedure within the pediatric population surgeons continued to introduce modifications on the procedure to overcome some of the challenges and minimize complications. ... -
Assessing small study effects and publication bias in orthodontic meta-analyses: a meta-epidemiological study
(2014-05)Objective: The aim of this study was to examine the presence and extent of small study effects and publication bias in meta-analyses (MAs) based on orthodontic studies. Materials and methods: Following an extensive ...