MBRU Knowledge Repository
Knowledge Repository at Mohammed Bin Rashid University of Medicine and Health Sciences
Welcome to digital archive and research repository of Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU). MBRU Knowledge Repository is a digital service that collects, preserves, and distributes digital material. MBRU's scholarly communications including theses, faculty publications, student projects, and departmental records and publications are the key digital records available in this repository. Repositories are important tools for preserving an organization's legacy; they facilitate digital preservation and scholarly communication.
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- Library Digital Archives
- Research and Scholarly work of College of Medicine
- Dubai Health Researchers Profiles
- Research and Scholarly work of Graduate Medical Education
- Research and Scholarly work of Hamdan Bin Mohammed College of Dental Medicine
- Research and Scholarly work of Hind Bint Maktoum College of Nursing and Midwifery
- Research and Scholarly work of IoL
- Research publications of other departments
- Theses and dissertations submitted by MBRU graduate and post-graduate students.
Recent Submissions
Prevalence and prenatal diagnosis of major congenital anomalies in Dubai: first insights and emerging patterns in a multicenter cohort study
(Springer Science and Business Media LLC, 2025-08-01) Akbar, Anjum
Background: Data on the prevalence and prenatal diagnosis of birth defects in Dubai is lacking. There are currently no guidelines specifying the content or standardized technique for performing prenatal ultrasound scans in Dubai. Maternal factors such as higher body mass index, weight gain, advanced maternal age, diabetes, and uterine scarring can affect imaging quality and prenatal anomaly detection, and are becoming more prevalent.
Methods: The primary objectives were to assess the birth prevalence of major congenital anomalies as defined by EUROCAT and the corresponding prenatal detection rates within a network of tertiary care centers in Dubai between 2019 and 2023. Secondary objectives included comparing prenatal detection based on the location of ultrasound scans - specifically, performed in a network of tertiary care facilities using international ultrasound guidelines versus scans done outside our network, and for scans performed at our facilities, assessing the influence of gestational age, sonologists, and maternal characteristics (body mass index, age, weight gain, diabetes, uterine scarring) through mixed-effect logistic regression. Scan duration and the need for repeat scans were evaluated using Spearman correlation tests.
Results: The prevalence of major anomalies was 335 (95% confidence interval: 301-372)/10000 live births and stillbirths, and 35.27/10000 for genetic anomalies. Prenatal detection was 70.3% for scans performed in our network, and 46.3% for scans done outside (P<.001). Most women (81.2%) had risk factors for reduced visibility. Scan duration and repeat scans correlated positively with C-sections, maternal age, and body mass index, though weakly. No significant association was found between external factors and prenatal detection (P=.9).
Conclusions: The prevalence of major anomalies was high. High detection rates were observed in a setting where practitioners come from diverse training backgrounds, and where most patients have risk factors for reduced visibility.
Incidence and outcome of biliary atresia in the United Arab Emirates: A multicenter national study.
(2025-07-01) Qazi, Abid
Background: While extensive research provides valuable insights into biliary atresia (BA) globally, there remain gaps in region-specific data, such as West Asia. We aim to evaluate the incidence and survival of patients with BA in the United Arab Emirates.
Pseudomyxoma peritonei of appendiceal mucinous neoplasm origin: A case report and review of literature.
(2024-12) Mousa, Ahmed Hafez
Appendiceal mucinous neoplasms, a rarity comprising less than 1% of all cancers, present intricate challenges in clinical management, and their incidence is on the rise. Notably, these neoplasms tend to metastasize intraperitoneally, leading to peritoneal carcinomatosis and concurrent accumulation of mucinous material, resulting in pseudomyxoma peritonei. Due to its spectrum of presentation, the classification of the appendiceal mucinous neoplasms remains a controversial subject with a range of management from a simple appendicectomy to a complex hyperthermic intraperitoneal chemotherapy (HIPEC). A 42-year-old Chadian male presented to the hospital with a sudden onset of right lower abdominal pain radiating to the inguinal region for 24 hours, associated with nausea and vomiting. The abdomen was distended and ascitic. Laboratory investigations revealed anemia, leukocytosis, hypernatremia, hypokalemia, elevated ESR, high CEA marker, and normal CA19-9. An abdominopelvic CT with contrast demonstrated extensive ascites and cystic masses in the liver, and pancreas with soft tissue thickening of the cecum; however, the appendix is not well-delineated. Patient was managed with chemotherapy and HIPEC followed by removal of all the affected parts. Nodules of the peritoneum and liver were submitted for histopathological analysis and a final diagnosis of pseudomyxoma peritonei of primary appendicular origin was established. This case highlights a case of extensive pseudomyxoma peritonei of appendicular origin managed aggressively by HIPEC and multiple resections of the involved organs. Prognosis of such a case is determined by the grade of the appendiceal tumor and the extent of invasion.
Ischemic Optic Neuropathy: A Review of Current and Potential Future Pharmacotherapies.
(2024-09-27) Badla, Beshr Abdulaziz
The treatment of arteritic anterior ischemic optic neuropathy (AAION), non-arteritic ischemic optic neuropathy (NAAION), and posterior ischemic optic neuropathy (PION) is a topic of ongoing research with mixed evidence on some pharmacotherapies and a need for more consensus. This manuscript provides an overview of these conditions' current, potential future, and attempted pharmacotherapies. AAION's current treatment regimen consists of high-dose steroids, with methotrexate, tocilizumab, and abatacept, being the most viable steroid-sparing therapy candidates. As for NAAION, the treatments being tried are vast, with mixed evidence supporting each modality. Similarly, despite the various treatment options explored, there still needs to be a universally effective therapy for PION. More research is needed to formulate an agreed-upon treatment regimen for these conditions.
Chronic Inflammatory Markers in Overweight and Obese Children: A Cross-sectional Analytical Study
(2024) Kumar, Ramachandran R
Introduction: Childhood obesity is associated with chronic low-grade systemic inflammation, which results in obesity-related comorbidities. This study compared the inflammatory markers between obese and normal children and assessed obesity-related comorbidities.