MBRU Knowledge Repository
Knowledge Repository at Mohammed Bin Rashid University of Medicine and Health Sciences
Welcome to digital archive and research repository of Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU). MBRU Knowledge Repository is a digital service that collects, preserves, and distributes digital material. MBRU's scholarly communications including theses, faculty publications, student projects, and departmental records and publications are the key digital records available in this repository. Repositories are important tools for preserving an organization's legacy; they facilitate digital preservation and scholarly communication.
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- Research and Scholarly work of College of Medicine
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- Research and Scholarly work of Graduate Medical Education
- Research and Scholarly work of Hamdan Bin Mohammed College of Dental Medicine
- Research and Scholarly work of IoL
- Research publications of other departments
- Theses and dissertations submitted by MBRU graduate and post-graduate students.
Recent Submissions
Association of salivary mmp-8 gene polymorphism with its protein expression in oral submucous fibrosis patients.
(2025-02-24) Khurshid, Yamna
OSF (Oral submucous fibrosis) is a chronic disease characterized by inflammation and progressive fibrosis of the submucosal tissues with the potential to progress into OSCC (Oral squamous cell carcinoma). Matrix metalloproteinases (MMP) are endopeptidases that play a role in extracellular matrix remodeling and pathophysiology of various diseases. The study aims to evaluate the gene polymorphism and protein expression of MMP-8 and their association with the severity of OSF. The cross-sectional study design involves patients diagnosed with OSF. DNA was extracted from saliva samples by the CTAB method followed by PCR and Sanger sequencing. The sequences were examined for MMP-8 polymorphism on Mega X software. ELISA was performed to assess the MMP-8 protein expression. The results of genetic polymorphism showed the alleles AG (rs11225395), TT (rs1861602574), CC (rs562617158), TT (rs2133511737), AA (rs1307439859), and CC (rs2133511706) consistent with disease severity. MMP-8 protein levels decreased with disease progression. Meanwhile, the association between the two showed a noteworthy significance with the presence of specific genetic variants, namely rs1320632, rs2133511732, rs1307439859, and rs2133511737, rs1307439859, rs562617158, rs11225395 shows a robust association with changes in MMP-8 protein expression. This study suggests a strong association between genotype and the modification of MMP-8 protein expression. In conclusion, MMP-8 may serve as a diagnostic biomarker in OSF.
The need for implementing a standardized, evidence-based emergency department discharge plan for optimizing adult asthma patient outcomes in the UAE, expert meeting report.
(2024-11-06) Buhumaid, Rasha
Asthma is a common chronic respiratory inflammatory disease that adversely affects patients' quality of life (QoL) and overall well-being. When asthma is not adequately controlled, there is a higher risk of exacerbations and hospitalizations, thereby increasing the direct and indirect costs associated with the treatment and productivity loss. Overreliance on SABA and underutilization of ICS in the management of asthma can result in suboptimal treatment and poor asthma control. Patients who visit the emergency department are more likely to have poorly controlled asthma. Ensuring that these patients are provided with an evidence-based treatment plan during discharge can help reduce the risk of future exacerbations and consequently reduce the burden on the UAE healthcare system.
Exploring the impact of stimulant medications on weight in children with attention deficit hyperactivity disorder in Dubai, United Arab Emirates
(2024) Al Eid, Faten; Albanna, Ammar; Joseph, Jessie; Talo, Sami; Jeyaseelan, Lakshmanan; Sultan, Meshal A
Attention deficit hyperactivity disorder (ADHD), prevalent in 5% of children worldwide, impacts academic performance and often coexists with psychiatric disorders. Psychostimulant medications are primary treatments for ADHD, enhancing dopamine to reduce symptoms. However, dopamine increase may cause appetite loss. This pioneering study in the United Arab Emirates (UAE) explores psychostimulant effects on weight in children diagnosed with ADHD, aiming to uncover unique regional characteristics and contributing factors to weight changes.
Occurrence of Femoral Nerve Palsy After Total Hip Arthroplasty (THA) Using the Direct Lateral Approach.
(2024-11) Nached, Yasmin; Al-Rawi, Zeinab; Abdelwahab, Abdulla; Elsayed, Ahmed; Ismaeil, Ali H
Femoral nerve palsy (FNP) is a rare but serious complication after total hip replacement (THP). Despite its rarity, FNP can significantly impact patient recovery and quality of life. This case report examines the occurrence of FNP in a patient following a primary THP and highlights the importance of surgical technique and postoperative detection and its management. We present the case of a 38-year-old male with a history of microscopic polyangiitis on long-term steroid treatment, who developed FNP following THP. The patient was admitted with non-traumatic right hip pain with osteoporotic fracture of the femoral head and underwent elective THP. Postoperatively, the patient showed quadriceps weakness and related sensory deficits. Postoperative assessments included physical examination, electromyography (EMG), nerve conduction studies (NCS), and magnetic resonance imaging to assess the extent of the nerve injury. EMG and NCS confirmed severe femoral mononeuropathy with profound active denervation changes. A subsequent magnetic resonance imaging revealed atrophy of the right sartorius and quadriceps femoris muscles. Conservative management was decided, including physiotherapy and close follow-up, which led to significant gradual improvement over six months, with enhanced knee range of motion (ROM), increased quadriceps strength, and improved sensation on the medial side of the leg and foot. Femoral nerve injuries, although uncommon, pose significant risks in THP. Excessive retraction during surgery may contribute to these injuries. Early diagnosis, conservative management, and interdisciplinary coordination are crucial to achieve optimal recovery.
Microcirculation: Current Perspective in Diagnostics, Imaging, and Clinical Applications.
(2024-11-10) Goswami, Nandu
This review discusses the pivotal role of microcirculation in maintaining tissue oxygenation and waste removal and highlights its significance in various pathological conditions. It delves into the cellular mechanisms underlying hemodynamic coherence, elucidating the roles of the endothelium, glycocalyx, and erythrocytes in sustaining microcirculatory integrity. Furthermore, the review gives comprehensive information about microcirculatory changes observed in cardiac surgery, sepsis, shock, and COVID-19 disease. Through comprehensive exploration, the review underscores the intricate relationship between microcirculation, disease states, and clinical outcomes, emphasizing the importance of understanding and monitoring microvascular dynamics in critical care settings.