Publication:
Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19

dc.contributor.authorNassir, Nasna
dc.contributor.authorTambi, Richa
dc.contributor.authorBankapur, Asma
dc.contributor.authorAl Heialy, Saba
dc.contributor.authorKaruvantevida, Noushad
dc.contributor.authorZehra, Binte
dc.contributor.authorBegum, Ghausia
dc.contributor.authorHameid, Reem Abdel
dc.contributor.authorAhmed, Awab
dc.contributor.authorShabestari, Seyed Ali Safizadeh
dc.contributor.authorKandasamy, Richard K
dc.contributor.authorLoney, Tom
dc.contributor.authorTayoun, Ahmad Abou
dc.contributor.authorNowotny, Norbert
dc.contributor.authorHachim, Mahmood Yaseen
dc.contributor.authorBerdiev, Bakhrom
dc.contributor.authorAlsheikh-Ali, Alawi
dc.contributor.authorUddin, Mohammed
dc.date.accessioned2022-03-17T07:21:00Z
dc.date.available2022-03-17T07:21:00Z
dc.date.issued2021
dc.description.abstractSummary: Understanding host cell heterogeneity is critical for unraveling disease mechanism. Utilizing large-scale single-cell transcriptomics, we analyzed multiple tissue specimens from patients with life-threatening COVID-19 pneumonia, compared with healthy controls. We identified a subtype of monocyte-derived alveolar macrophages (MoAMs) where genes associated with severe COVID-19 comorbidities are significantly upregulated in bronchoalveolar lavage fluid of critical cases. FCGR3B consistently demarcated MoAM subset in different samples from severe COVID-19 cohorts and in CCL3L1-upregulated cells from nasopharyngeal swabs. In silico findings were validated by upregulation of FCGR3B in nasopharyngeal swabs of severe ICU COVID-19 cases, particularly in older patients and those with comorbidities. Additional lines of evidence from transcriptomic data and in vivo of severe COVID-19 cases suggest that FCGR3B may identify a specific subtype of MoAM in patients with severe COVID-19 that may present a novel biomarker for screening and prognosis, as well as a potential therapeutic target.en_US
dc.identifier.other204-2021.174
dc.identifier.urihttps://repository.mbru.ac.ae/handle/1/916
dc.language.isoenen_US
dc.subjectFCGR3Ben_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.titleSingle-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19en_US
dc.typeArticleen_US
dspace.entity.typePublicationen_US

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