Publication: Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19
dc.contributor.author | Nassir, Nasna | |
dc.contributor.author | Tambi, Richa | |
dc.contributor.author | Bankapur, Asma | |
dc.contributor.author | Al Heialy, Saba | |
dc.contributor.author | Karuvantevida, Noushad | |
dc.contributor.author | Zehra, Binte | |
dc.contributor.author | Begum, Ghausia | |
dc.contributor.author | Hameid, Reem Abdel | |
dc.contributor.author | Ahmed, Awab | |
dc.contributor.author | Shabestari, Seyed Ali Safizadeh | |
dc.contributor.author | Kandasamy, Richard K | |
dc.contributor.author | Loney, Tom | |
dc.contributor.author | Tayoun, Ahmad Abou | |
dc.contributor.author | Nowotny, Norbert | |
dc.contributor.author | Hachim, Mahmood Yaseen | |
dc.contributor.author | Berdiev, Bakhrom | |
dc.contributor.author | Alsheikh-Ali, Alawi | |
dc.contributor.author | Uddin, Mohammed | |
dc.date.accessioned | 2022-03-17T07:21:00Z | |
dc.date.available | 2022-03-17T07:21:00Z | |
dc.date.issued | 2021 | |
dc.description.abstract | Summary: Understanding host cell heterogeneity is critical for unraveling disease mechanism. Utilizing large-scale single-cell transcriptomics, we analyzed multiple tissue specimens from patients with life-threatening COVID-19 pneumonia, compared with healthy controls. We identified a subtype of monocyte-derived alveolar macrophages (MoAMs) where genes associated with severe COVID-19 comorbidities are significantly upregulated in bronchoalveolar lavage fluid of critical cases. FCGR3B consistently demarcated MoAM subset in different samples from severe COVID-19 cohorts and in CCL3L1-upregulated cells from nasopharyngeal swabs. In silico findings were validated by upregulation of FCGR3B in nasopharyngeal swabs of severe ICU COVID-19 cases, particularly in older patients and those with comorbidities. Additional lines of evidence from transcriptomic data and in vivo of severe COVID-19 cases suggest that FCGR3B may identify a specific subtype of MoAM in patients with severe COVID-19 that may present a novel biomarker for screening and prognosis, as well as a potential therapeutic target. | en_US |
dc.identifier.other | 204-2021.174 | |
dc.identifier.uri | https://repository.mbru.ac.ae/handle/1/916 | |
dc.language.iso | en | en_US |
dc.subject | FCGR3B | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.title | Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19 | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | en_US |