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dc.contributor.authorAlsheikh-Ali, Alawi A.
dc.date.accessioned2021-08-02T11:26:19Z
dc.date.available2021-08-02T11:26:19Z
dc.date.issued2018-12
dc.identifier.other204-2018.53
dc.identifier.urihttps://repository.mbru.ac.ae/handle/1/319
dc.description.abstractAim: To evaluate the prevalence and impact of the prescribing of an evidence - based cardiac medication (EBM) combination on 1-month, 6-months, and 12-months all-cause mortality in patients with acute coronary syndrome (ACS). Methods: Data were analyzed from 3681 consecutive patients diagnosed with ACS admitted to 29 hospitals in 4 Middle Eastern countries from January 2012 to January 2013. The EBM combination consisted of concurrent prescribing of an antiplatelet therapy, angiotensin - converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB), β- blocker, and a statin, at hospital discharge. Analyses were performed using univariate and multivariate statistical techniques. Results: The overall mean age of the cohort was 60 ± 13 years, 66% (n = 2436) were males. In all, 69% (n = 2542) of the patients received the quadruple EBM combination at discharge. Two-way interactions between EBM and age (P=0.824), EBM and GRACE risk score (P=0.873) and between EBM and discharge diagnosis (P =0.836) were all not statistically significant. Adjusting for demographic and clinical characteristics, the prescribing of EBM combination was associated with significantly lower cumulative all-cause mortality at 1-month (adjusted OR (aOR), 0.43; 95% confidence interval (CI): 0.24-0.79; P =0.007), which persisted at 6-months (aOR, 0.52; 95% CI: 0.38- 0.72; P<0.001) and at 12-months of follow-up (aOR, 0.58; 95% CI: 0.44-0.75; P <0.001) post hospital discharge. Conclusions: Among patients discharged after an ACS event, concurrent EBM prescribing was associated with lower all-cause mortality that persists for up to 12-months posthospital discharge. The relative benefits of EBMs were also consistent across age, GRACE risk score, and discharge diagnosis.en_US
dc.language.isoenen_US
dc.subjectAcute coronary syndromeen_US
dc.subjectArabsen_US
dc.subjectEvidence-Based medicineen_US
dc.subjectMiddle Easten_US
dc.subjectMortalityen_US
dc.titleEffect of evidence-based cardiac drug therapy on mortality in patients with acute coronary syndrome: Findings from the Gulf COAST registryen_US
dc.typeArticleen_US


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