Show simple item record

dc.contributor.authorKader, Kamal Hassan
dc.date.accessioned2021-03-29T07:20:21Z
dc.date.available2021-03-29T07:20:21Z
dc.date.issued2017-11-20
dc.identifier.other204-2017.52
dc.identifier.urihttps://repository.mbru.ac.ae/handle/1/244
dc.description.abstractAbstract: In this study, the hepatoprotective and anti-fibrotic actions of nootkatone (NTK) were investigated using carbon tetrachloride (CCl4)-induced liver fibrosis in mice. CCl4 administration elevated serum aspartate and alanine transaminases levels, respectively. In addition, CCl4 produced hepatic oxidative and nitrative stress, characterized by diminished hemeoxygenase-1 expression, antioxidant defenses, and accumulation of 4-hydroxynonenal and 3-nitrotyrosine. Furthermore, CCl4 administration evoked profound expression of pro-inflammatory cytokine expressions such as tumor necrosis factor-𝛼, monocyte chemoattractant protein-1, and interleukin-1𝛽 in hepatic tissues, which corroborated with nuclear factor 𝜅B activation. Additionally, CCl4-treated animals exhibited higher apoptosis, characterized by increased caspase 3 activity,DNA fragmentation, and poly (ADP-ribose) polymerase activation. Moreover, histological and biochemical investigations revealed marked fibrosis in the livers of CCl4-administered animals. However, NTK treatment mitigated CCl4-induced phenotypic changes. In conclusion, our findings suggest that NTK exerts hepatoprotective and anti-fibrotic actions by suppressing oxidative stress, inflammation, and apoptosis.en_US
dc.language.isoenen_US
dc.subjectApoptosisen_US
dc.subjectInflammationen_US
dc.subjectLiver fibrosisen_US
dc.subjectNootkatoneen_US
dc.subjectOxidative stressen_US
dc.titleNootkatone confers hepatoprotective and anti-fibrotic actions in amurine model of liver fibrosis by suppressing oxidative stress, inflammation, and apoptosisen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record