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Founder mutation in IKBKAP gene causes vestibular impairment in familial dysautonomia
(2018)
Objective:
To assess vestibular function in patients with familial dysautonomia (FD), a hereditary sensory and autonomic neuropathy – caused by a mutation in the IKBKAP gene (c.2204 + 6 T > C) – and characterized by marked ...
Muscle sympathetic nerve activity-coupled changes in brain activity during sustained muscle pain
(2018-02-07)
Introduction:
Long-lasting experimental muscle pain elicits divergent muscle sympathetic responses, with some individuals exhibiting a persistent increase in muscle sympathetic nerve activity (MSNA), and others a decrease. ...
The metaboreflex does not contribute to the increase in muscle sympathetic nerve activity to contracting muscle during static exercise in humans
(2018-01-08)
Abstract:
Both central command and metaboreflex inputs from contracting muscles increase muscle sympathetic nerve activity (MSNA) to non-contracting muscle during sustainedisometric exercise. We recently showed that MSNA ...
The relationship between thalamic GABA content and resting cortical rhythm in neuropathic pain
(2018-01)
Abstract:
Recurrent thalamocortical connections are integral to the generation of brain rhythms and it is thought that the inhibitory action of the thalamic reticular nucleus is critical in setting these rhythms. Our work ...