Browsing Faculty Publications (CoM) by Author "Macefield, Vaughan G."
Now showing items 1-7 of 7
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Founder mutation in IKBKAP gene causes vestibular impairment in familial dysautonomia
Macefield, Vaughan G. (2018)Objective: To assess vestibular function in patients with familial dysautonomia (FD), a hereditary sensory and autonomic neuropathy – caused by a mutation in the IKBKAP gene (c.2204 + 6 T > C) – and characterized by marked ... -
The metaboreflex does not contribute to the increase in muscle sympathetic nerve activity to contracting muscle during static exercise in humans
Macefield, Vaughan G. (2018-01-08)Abstract: Both central command and metaboreflex inputs from contracting muscles increase muscle sympathetic nerve activity (MSNA) to non-contracting muscle during sustainedisometric exercise. We recently showed that MSNA ... -
Muscle sympathetic nerve activity and hemodynamic responses to venous distension: does sex play a role?
Macefield, Vaughan G. (2019)Peripheral venous distension mechanically stimulates type III/IV sensory fibers in veins and evokes pressor and sympathoexcitatory reflex responses in humans. As young women have reduced venous compliance and impaired ... -
Muscle sympathetic nerve activity peaks in the first trimester in healthy pregnancy: a longitudinal case study
Macefield, Vaughan G. (2017-07-03)Objective and methods: Muscle sympathetic nerve activity and baroreflex sensitivity were examined at rest before, during (weeks 6, 11, 17, 22, 25, 33 and 36) and after a normotensive pregnancy. Results: Muscle sympathetic ... -
Muscle sympathetic nerve activity-coupled changes in brain activity during sustained muscle pain
Macefield, Vaughan G. (2018-02-07)Introduction: Long-lasting experimental muscle pain elicits divergent muscle sympathetic responses, with some individuals exhibiting a persistent increase in muscle sympathetic nerve activity (MSNA), and others a decrease. ... -
The relationship between thalamic GABA content and resting cortical rhythm in neuropathic pain
Macefield, Vaughan G. (2018-01)Abstract: Recurrent thalamocortical connections are integral to the generation of brain rhythms and it is thought that the inhibitory action of the thalamic reticular nucleus is critical in setting these rhythms. Our work ... -
Vestibular Modulation of Sympathetic Nerve Activity to Muscle and Skin in Humans
Macefield, Vaughan G. (2017-07-26)Abstract: We review the existence of vestibulosympathetic reflexes in humans. While several methods to activate the human vestibular apparatus have been used, galvanic vestibular stimulation (GVS) is a means of selectively ...