Browsing Faculty Publications (CoM) by Author "Ali, Fahad R"
Now showing items 1-6 of 6
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Dephosphorylation of the Proneural Transcription Factor ASCL1 Re-Engages a Latent Post-Mitotic Differentiation Program in Neuroblastoma
Ali, Fahad R (2020)Abstract: Pediatric cancers often resemble trapped developmental intermediate states that fail to engage the normal differentiation program, typified by high-risk neuroblastoma arising from the developing sympathetic ... -
Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis
Ibragimova, Shakhzada; Ramachandran, Revathy; Ali, Fahad R; Lipovich, Leonard; Ho, Samuel B (2021)Abstract: The recent increases in cancer incidences have been linked to lifestyle changes that result in obesity and metabolic syndrome. It is now evident that these trends are associated with the profound changes that ... -
Elevated ASCL1 activity creates de novo regulatory elements associated with neuronal diferentiation
Ali, Fahad R; Gomez, Roshna Lawrence; Tayoun, Ahmad N. Abou (2022)Background: The pro-neural transcription factor ASCL1 is a master regulator of neurogenesis and a key factor necessary for the reprogramming of permissive cell types to neurons. Endogenously, ASCL1 expression is often ... -
The proneural transcription factor ASCL1 regulates cell proliferation and primes for differentiation in neuroblastoma
Ali, Fahad R (2022)Abstract: Neuroblastoma is believed to arise from sympathetic neuroblast precursors that fail to engage the neuronal differentiation programme, but instead become locked in a pro-proliferative developmental state. ... -
Super-enhancer associated core regulatory circuits mediate susceptibility to retinoic acid in neuroblastoma cells
Gomez, Roshna Lawrence; Ramachandran, Revathy; Abou Tayoun, Ahmad; Ali, Fahad R (2022)Abstract: Neuroblastoma is a pediatric tumour that accounts for more than 15% of cancer-related deaths in children. High-risk tumours are often difficult to treat, and patients’ survival chances are less than 50%. Retinoic ... -
Tumoral heterogeneity in neuroblastoma
Gomez, Roshna Lawrence; Ibragimova, Shakhzada; Ramachandran, Revathy; Ali, Fahad R (2022)Abstract: Neuroblastoma is a solid, neuroendocrine tumor with divergent clinical behavior ranging from asymptomatic to fatal. The diverse clinical presentations of neuroblastoma are directly linked to the high intra- and ...