Browsing Faculty Publications (CoM) by Author "Abou Tayoun, Ahmad"
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A draft human pangenome reference
Abou Tayoun, Ahmad (2023)Introduction: Here the Human Pangenome Reference Consortium presents a frst draft of the human pangenome reference. The pangenome contains 47 phased, diploid assemblies from a cohort of genetically diverse individuals1 . ... -
The genomic landscape of rare disorders in the Middle East
Rabea, Fatma; Abou Tayoun, Ahmad (2023)Background: Rare diseases collectively impose a significant burden on healthcare systems, especially in underserved regions, like the Middle East, which lack access to genomic diagnostic services and the associated ... -
Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) in a Middle Eastern patient cohort
Abou Tayoun, Ahmad (2023)Objective: This is a comprehensive characteristic study of Kawasaki disease (KD) and Multi system inflammatory syndrome in children (MIS-C) in the Middle East that creates a formula to differentiate between the two. ... -
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
Abou Tayoun, Ahmad; Alosaimi, Mohammed Faraj (2023)Background: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases ... -
Super-enhancer associated core regulatory circuits mediate susceptibility to retinoic acid in neuroblastoma cells
Gomez, Roshna Lawrence; Ramachandran, Revathy; Abou Tayoun, Ahmad; Ali, Fahad R (2022)Abstract: Neuroblastoma is a pediatric tumour that accounts for more than 15% of cancer-related deaths in children. High-risk tumours are often difficult to treat, and patients’ survival chances are less than 50%. Retinoic ...