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Now showing items 71-80 of 82
Utility of shock index in 24,636 patients presenting with acute coronary syndrome
(2019)
Background:
Shock index is a bedside reflection of integrated response of the cardiovascular and nervous systems. We aimed to evaluate the utility of shock index (heart rate/systolic blood pressure) in patients presenting ...
1,2,3-Triazolyl ester of ketorolac (15K), a potent PAK1 blocker, inhibits both growth and metastasis of orthotopic human pancreatic cancer xenografts in mice
(2019)
More than 90% of human pancreatic cancers carry the oncogenic mutant of Ki-RAS and their growth depends on its downstream kinase PAK1, mainly because PAK1 blocks the apoptosis of cancer cells selectively. We developed a ...
Use of real-world evidence for healthcare decision-making in the Middle East: practical considerations and future directions
(2019)
Introduction:
Real-world evidence (RWE) is increasingly being used in coverage, reimbursement and formulary decisions for medicines globally.
Areas covered:
The Middle East (ME) region is significantly behind in ...
Development of a national Department of Veterans Affairs mortality risk prediction model among patients with cirrhosis
(2019)
Objective: Cirrhotic patients are at high hospitalization risk with subsequent high mortality. Current risk prediction models have varied performances with methodological room for improvement. We used current analytical ...
Neural Processing of Dynamic Animated Social Interactions in Young Children With Autism Spectrum Disorder: A High-Density Electroencephalography Study
(2019-08-22)
Background:
Atypical neural processing of social visual information contributes to impaired social cognition in autism spectrum disorder. However, evidence for early developmental alterations in neural processing of ...
Predicting 30‑Day Hospital Readmission Risk in a National Cohort of Patients with Cirrhosis
(2019)
Background:
Early hospital readmission for patients with cirrhosis continues to challenge the healthcare system. Risk stratification may help tailor resources, but existing models were designed using small, single-institution ...
Rickettsia Sca2 Recruits Two Actin Subunits for Nucleation but Lacks WH2 Domains.
(2019-02-05)
Abstract:
The Rickettsia 1800-amino-acid auto transporter protein surface cell antigen 2 (Sca2) promotes actin polymerization on the surface of the bacterium to drive its movement using an actin comet-tail mechanism. Sca2 ...
Novel mutations in actionable breast cancer genes by targeted sequencing in an ethnically homogenous cohort
(2019)
Background:
Genetic testing is becoming an essential tool for breast cancer (BC) diagnosis and treatment pathway, and particularly important for early detection and cancer prevention. The purpose of this study was to ...
Examining Associations Between Physician Data Utilization for Practice Improvement and Lifelong Learning
(2019)
Introduction:
Practice data can inform the selection of educational strategies; however, it is not widely used, even when available. This study’s purpose was to determine factors that influence physician engagement with ...
Clinical Performance Improvement in Diabetes: Adapting a Proven Model in Dubai
(2019)
Abstract:
The Dubai Performance Improvement (P.I.) project in Diabetes (Dubai-PID) will replicate the 6-phase process used in the European Performance Improvement in Diabetes Demonstration project (EPIDD), an initiative ...