Search
Now showing items 51-60 of 82
Role of IL-17 in asthma pathogenesis and its implications for the clinic
(2019)
Introduction:
Asthma is a respiratory disorder typically characterized by T-helper type 2 (Th2) inflammation that is mediated by cytokines, including IL-4, IL-5 and IL-13. Pathophysiologically, airway inflammation involving ...
Learning from the law. A review of 21 years of litigation for nerve injury following central neuraxial blockade in obstetrics
(2019)
Abstract:
Medicolegal claims for neurological injury following the use of central neuraxial blockade in childbirth represent the second most common claim against obstetric anaesthetists. We present an analysis of 55 cases ...
A rare case of blue nevus in the rectum
(2019)
Abstract:
A 54 year old female of Sudanese origin with a history of hypothyroidism and hyperlipidemia presented to the gastroenterology department complaining of chronic abdominal pain, nausea and heartburn. Colonoscopy ...
Large-scale all-atom molecular dynamics alanine-scanning of IAPP octapeptides provides insights into the molecular determinants of amyloidogenicity
(2019-02-21)
Abstract:
In order to investigate the early phase of the amyloid formation by the short amyloidogenic octapeptide sequence (‘NFGAILSS’) derived from IAPP, we carried out a 100ns all-atom molecular dynamics (MD) simulations ...
Novel mutations in actionable breastcancer genes by targeted sequencing in anethnically homogenous cohort
(2019)
Background:Genetic testing is becoming an essential tool for breast cancer (BC) diagnosis and treatment pathway,and particularly important for early detection and cancer prevention. The purpose of this study was to explore ...
Augmenting Flexnerism Via Twitterism: Need for Integrating Social Media Application in Blueprinting Pedagogical Strategies for Undergraduate Medical Education
(2019-03-25)
Background:
Flexnerism, or “competency-based medical education,” advocates that formal analytic reasoning, the kind of rational thinking fundamental to the basic sciences, especially the natural sciences, should be the ...
Demystifying Smoker’s Paradox: A Propensity Score–Weighted Analysis in Patients Hospitalized With Acute Heart Failure
(2019)
Background: Smoker’s paradox has been observed with several vascular disorders, yet there are limited data in patients with acute heart failure (HF). We examined the effects of smoking in patients with acute HF using data ...
Circadian Rhythm and ST-Segment Elevation Myocardial Infarction: Insights From the Third Gulf Registry of Acute Coronary Events (Gulf RACE-3Ps)
(2019-04)
Abstract:
Circadian rhythms have been identified in multiple physiological processes that may affect cardiovascular diseases, yet little is known about the impact of circadian rhythm on acute ST-segment elevation myocardial ...
Increases in statin eligibility to reduce cardiovascular risk according to the 2013 ACC/AHA cholesterol guidelines in the Africa Middle East region: a sub-analysis of the Africa Middle East Cardiovascular Epidemiological (ACE) study
(2019)
Background:
With development of cholesterol management guidelines by the American College of Cardiology/American Heart Association (ACC/AHA), more individuals at risk of cardiovascular disease may be eligible for statin ...
One-year risks of stroke and death in patients with atrial fibrillation from different clinical settings: The Gulf SAFE registry and Darlington AF registry
(2019)
Background:
AF patients from different clinical settings may have varying outcomes. We aimed to provide patient-level comparisons using two cohorts of patients with AF from different settings.
Purpose:
We aimed to ...