MBRU Knowledge Repository: Recent submissions
Now showing items 221-240 of 1430
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Obesity and female infertility
(2023)Abstract: Infertility is a significant global health issue, with a negative impact on people's wellbeing and human rights. Despite the longstanding association between obesity and infertility, there remains uncertainty, ... -
Hiccups, Hypersalivation, Hallucinations in Parkinson’s Disease: New Insights, Mechanisms, Pathophysiology, and Management
(2023)Abstract: Parkinson’s disease (PD) is a chronic, progressive neurological disorder and the second most common neurodegenerative condition. We report three common but overlooked symptoms in PD—hiccups, hypersalivation, ... -
Social Determinants of Health and Mortality After Premature and Non-premature Acute Coronary Syndrome
(2023)Objective: To describe and compare the determinants of 1-year mortality after premature vs non-premature acute coronary syndrome (ACS). Patients and Methods: Participants presenting with ACS were enrolled in a ... -
Effects of Atrial Fibrillation Screening According to N-Terminal Pro-B-Type Natriuretic Peptide: A Secondary Analysis of the Randomized LOOP Study
(2023)Background: Research suggests NT-proBNP (N-terminal pro-B-type natriuretic peptide) to be a strong predictor of incident atrial fibrillation (AF) and stroke. However, its utility in AF screening remains unknown. The aim ... -
Lung Epithelial Cells from Obese Patients Have Impaired Control of SARS-CoV-2 Infection
(2023)Abstract: Obesity is known to increase the complications of the COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the exact mechanisms of SARSCoV-2 infection ... -
Electrocardiographic markers of subclinical atrial fibrillation detected by implantable loop recorder: insights from the LOOP Study
(2023)Aims: Insights into subclinical atrial fibrillation (AF) development are warranted to inform the strategies of screening and subsequent clinical management upon AF detection. Hence, this study sought to characterize the ... -
Appendectomy as part of Ladd’s procedure: a systematic review and survey analysis
(2023)Background: Ladd’s Procedure has been the surgical intervention of choice in the management of congenital intestinal malrotation for the past century. Historically, the procedure included performing an appendectomy to ... -
The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps
(2023)Introduction: Although we have sent humans into space for more than 50 years crucial questions regarding kidney physiology, volume regulation and osmoregulation remain unanswered. The complex interactions between the ... -
An updated overview of cyanidins for chemoprevention and cancer therapy
(2023)Abstract: Anthocyanins are colored polyphenolic compounds that belong to the flavonoids family and are largely present in many vegetables and fruits. They have been used in traditional medicine in many cultures for a long ... -
Single particle cryo-EM analysis of Rickettsia conorii Sca2 reveals a formin-like core
(2023)Abstract: Spotted fever group Rickettsia undergo actin-based motility inside infected eukaryotic cells using Sca2 (surface cell antigen 2): an ~ 1800 amino-acid monomeric autotransporter protein that is surface-attached ... -
The relationship of online pre-recorded neurology mini-lectures to medical student assessment: a pilot study
(2023)Introduction: eLearning has become an essential part of medical education. However, there is a lack of published research on student engagement with online pre-recorded mini-lectures and its relation to assessment. The ... -
Minithoracotomy versus sternotomy in mitral valve surgery: meta-analysis from recent matched and randomized studies
(2023)Background: There is still ongoing debate about the benefits of mini-thoracotomy (MTH) approach in mitral valve surgery in comparison with complete sternotomy (STER). This study aims to update the current evidence with ... -
Mimicking Mother Nature in the Field of Human Reproduction?
(2023)Introduction: Although humans have made significant progress in understanding reproductive events, nature still has more information to reveal. Towards the end of the 19th century, humans started studying reproductive ... -
Non-coding regions of nuclear-DNA-encoded mitochondrial genes and intergenic sequences are targeted by autoantibodies in breast cancer
(2023)Introduction: Autoantibodies against mitochondrial-derived antigens play a key role in chronic tissue inflammation in autoimmune disorders and cancers. Here, we identify autoreactive nuclear genomic DNA (nDNA)-encoded ... -
A systematic review on the available treatment modalities for Bacillus Calmette– Guérin-unresponsive carcinoma in situ and tumors in patients who are ineligible for or decline radical cystectomy
(2023)Introduction: Globally, urothelial bladder carcinoma is a disease which carries a poor prognosis. There are various treatment modalities for urothelial bladder carcinoma with intravesical Bacillus Calmette–Guérin ... -
The Role of Genetic Variants in the Long Non-Coding RNA Genes MALAT1 and H19 in the Pathogenesis of Childhood Obesity
(2023)Abstract: Long non-coding RNAs (lncRNAs) play important roles in the maintenance of metabolic homeostasis. Recently, many studies have suggested that lncRNAs, such as Metastasis Associated Lung Adenocarcinoma Transcript ... -
A Rare Case of Miller Fisher Syndrome in a 45- Year-Old Female
(2023)Abstract: Miller Fisher syndrome (MFS) is an uncommon form of Guillain-Barré syndrome (GBS), a neurological condition that is acquired, degenerative, demyelinating, and frequently characterized by gradual, symmetrical ... -
Cis-Nerolidol Inhibits MAP Kinase and NF-κB Signaling Pathways and Prevents Epithelial Tight Junction Dysfunction in Colon Inflammation: In Vivo and In Vitro Studies
(2023)Abstract: Inflammation of the GI tract leads to compromised epithelial barrier integrity, which increases intestine permeability. A compromised intestinal barrier is a critical event that leads to microbe entry and ... -
Digitally measuring solar ultraviolet radiation in outdoor workers: A study protocol for establishing the use of electronic personal dosimeters in Portugal
(2023)Introduction: The rising incidence of skin cancer over the years has made it a significant public and occupational health issue. However, skin cancer is highly preventable, mainly through reduced exposure to solar ... -
A Rare Case of Primary Mycobacterium tuberculosis Myositis of the Thigh in an Immunocompetent Infant
(2023)Abstract: Mycobacterium tuberculosis (MTB) infection is a serious health condition that affects individuals of all age groups. Although MTB infections are more common in immunocompromised patients, they are frequently ...