This paper presents a systematic literature review as part of an MSc program in specialist nursing. The review focusses on exploring the experiences of the Internationally Educated Nurses (IENs) with the cultural differences and its impact on the communication when working in a clinical setting which is different from their home country. The paper will begin by setting the chosen topic in context, giving some background to the important role IENs play in health and social care. The paper will then describe the methodology including the review design, the search strategy, the inclusion and exclusion criteria, the data bases accessed, the key search words and terms used. The paper will present the findings including the articles chosen to be part of the review, the overall results from these articles, which will be presented through a Preferred Reporting Items for Systematic Reviews and Meta-Analyses flowchart (PRISMA) and a table. Having critically reviewed, appraised, and assessed the quality of the articles and the findings. The common themes which they are 1. Need for support, 2. Communication, 3. Adjustment and they will be discussed in detail. The limitations and strengths of the review will be addressed and implications for practice will be presented.