Browsing College of Medicine (CoM) by Author "Hachim, Mahmood Yaseen"
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Genetic Variants of the PLCXD3 Gene Are Associated with Risk of Metabolic Syndrome in the Emirati Population
Hachim, Mahmood Yaseen (2020)Abstract: Phosphatidylinositol-specific phospholipase C X domain 3 (PLCXD3) has been shown to influence pancreatic _-cell function by disrupting insulin signaling. Herein, we investigated two genetic variants in the ... -
Genomic, Proteomic, and Phenotypic Spectrum of Novel O-Sialoglycoprotein Endopeptidase Variant in Four Affected Individuals With Galloway-Mowat Syndrome
Hachim, Mahmood Yaseen (2022)Introduction: Galloway-Mowat syndrome is a rare autosomal recessive disease characterized by a unique combination of renal and neurological manifestations, including early-onset steroidresistant nephrotic syndrome, ... -
Healthcare Derived Smart Watches and Mobile Phones are Contaminated Niches to Multidrug Resistant and Highly Virulent Microbes
Boucherabine, Syrine; Nassar, Rania; Mohamed, Lobna; Alqutami, Fatma; Zaher, Shroque; Hachim, Mahmood Yaseen; Senok, Abiola (2022)Background: As high touch wearable devices, the potential for microbial contamination of smart watches is high. In this study, microbial contamination of smart watches of healthcare workers (HCWs) was assessed and compared ... -
Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic β-cells
Hachim, Mahmood Yaseen (2021)Abstract: Iron overload promotes the generation of reactive oxygen species (ROS). Pancreatic β-cells can counter oxidative stress through multiple anti-oxidant responses. Herein, RNA-sequencing was used to describe the ... -
Higher Temperatures, Higher Solar Radiation, and Less Humidity Is Associated With Poor Clinical and Laboratory Outcomes in COVID-19 Patients
Hachim, Mahmood Yaseen (2021)Background: The COVID-19 pandemic varies between countries, with suggestions that weather might contribute to the transmission mode, disease presentation, severity, and clinical outcomes. Yet the exact link between climate ... -
Identification of Predictive Biomarkers for Lymph Node Involvement in Obese Women With Endometrial Cancer
Hachim, Mahmood Yaseen (2021)Abstract: Obesity, an established risk factor for endometrial cancer (EC), is also associated to increased risks of intraoperative and postoperative complications. A reliable tool to identify patients at low risk for lymph ... -
Identification of Specific Biomarkers and Pathways in the Treatment Response of Infliximab for Inflammatory Bowel Disease: In-Silico Analysis
Kaddoura, Rachid; Ghelani, Hardik; Alqutami, Fatma; Altaher, Hala; Hachim, Mahmood Yaseen; Jan, Reem Kais (2023)Background: Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract. In biological therapy, infliximab became the first anti-tumor necrosis factor (TNF) agent approved for ... -
IL-13 Augments Histone Demethylase JMJD2B/KDM4B Expression Levels, Activity, and Nuclear Translocation in Airway Fibroblasts in Asthma
Hachim, Mahmood Yaseen (2021)Purpose: Asthma is one of the most common obstructive pulmonary diseases worldwide. Epigenetic alterations, including DNA methylation and histone modifications, have been reported to contribute to asthma pathogenesis. ... -
The impact of CBP expression in estrogen receptor-positive breast cancer
Hachim, Mahmood Yaseen (2021)Background: The development of new biomarkers with diagnostic, prognostic and therapeutic prominence will greatly enhance the management of breast cancer (BC). Several reports suggest the involvement of the histone ... -
In Silico Analysis of Publicly Available Transcriptomic Data for the Identification of Triple-Negative Breast Cancer-Specific Biomarkers
Kaddoura, Rachid; Alqutami, Fatma; Asbaita, Mohamed; Hachim, Mahmood Yaseen (2023)Background: Breast cancer is the most common type of cancer among women and is classified into multiple subtypes. Triple-negative breast cancer (TNBC) is the most aggressive subtype, with high mortality rates and limited ... -
Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial Cells
Hachim, Mahmood Yaseen; Heialy, Saba Al; Senok, Abiola C. (2020)Abstract: Current guidelines for COVID-19 management recommend the utilization of various repurposed drugs. Despite ongoing research toward the development of a vaccine against SARS-CoV-2, such a vaccine will not be available ... -
Kidney Dysfunction among COVID-19 Patients in the United Arab Emirates
Hachim, Mahmood Yaseen (2021)Objectives: We sought to determine the estimated glomerular filtration rate (eGFR) among patients with COVID-19 and to examine its correlation with different demographic, clinical, and laboratory characteristics. ... -
Lung Epithelial Cells from Obese Patients Have Impaired Control of SARS-CoV-2 Infection
Jalaleddine, Nour; Hachim, Mahmood Yaseen; Senok, Abiola; Al Heialy, Saba (2023)Abstract: Obesity is known to increase the complications of the COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the exact mechanisms of SARSCoV-2 infection ... -
M1 Polarization Markers Are Upregulated in Basal-Like Breast Cancer Molecular Subtype and Associated With Favorable Patient Outcome
Hachim, Mahmood Yaseen (2020)Background: Breast cancer heterogeneity is an essential element that plays a role in the therapy response variability and the patient’s outcome. This highlights the need for more precise subtyping methods that focus not ... -
Metagenomic Sequencing and Reverse Transcriptase PCR Reveal That Mobile Phones and Environmental Surfaces Are Reservoirs of Multidrug-Resistant Superbugs and SARS-CoV-2
Boucherabine, Syrine; Nassar, Rania; Zaher, Shroque; Mohamed, Lobna; Alqutami, Fatma; Hachim, Mahmood Yaseen; Senok, Abiola (2022)Background: Mobile phones of healthcare workers (HCWs) can act as fomites in the dissemination of microbes. This study was carried out to investigate microbial contamination of mobile phones of HCWs and environmental ... -
Molecular Basis of Cardiac and Vascular Injuries Associated With COVID-19
Hachim, Mahmood Yaseen; Al Heialy, Saba; Senok, Abiola; Alsheikh-Ali, Alawi (2020)Background: Coronavirus disease 2019 (COVID-19) is a viral respiratory illness caused by the novel coronavirus SARS-CoV-2. The presence of the pre-existing cardiac disease is associated with an increased likelihood of ... -
The Molecular Basis of Gender Variations in Mortality Rates Associated With the Novel Coronavirus (COVID-19) Outbreak
Hachim, Mahmood Yaseen (2021)Abstract: Since the outbreak of the novel coronavirus disease (COVID-19) at the end of 2019, the clinical presentation of the disease showed a great heterogeneity with a diverse impact among different subpopulations. ... -
Molecular Examination of Differentially Expressed Genes in the Brains of Experimental Autoimmune Encephalomyelitis Mice Post Herceptin Treatment
Hachim, Mahmood Yaseen (2021)Objective: Herceptin (trastuzumab) is an approved drug for treating HER2+ breast cancer patients, but its use for other diseases is not established. We sought to investigate the effects of Herceptin on ameliorating ... -
Monocyte distribution width as a novel sepsis indicator in COVID-19 patients
Alsuwaidi, Laila; Al Heialy, Saba; Han, Aaron; Hachim, Mahmood Yaseen (2022)Background: The severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a highly transmittable virus which causes the novel coronavirus disease (COVID-19). Monocyte distribution width (MDW) is an in-vitro hematological ... -
N6-Acetyl-L-Lysine and p-Cresol as Key Metabolites in the Pathogenesis of COVID-19 in Obese Patients
Jalaleddine, Nour; Hachim, Mahmood Yaseen; Senok, Abiola; Kandasamy, Richard K; Al Heialy, Saba (2022)Abstract: Despite the growing number of the vaccinated population, COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global health burden. Obesity, a metabolic syndrome affecting ...