Browsing by Author "Hachim, Mahmood Yaseen"
Now showing items 41-55 of 55
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Monocyte distribution width as a novel sepsis indicator in COVID-19 patients
Alsuwaidi, Laila; Al Heialy, Saba; Han, Aaron; Hachim, Mahmood Yaseen (2022)Background: The severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a highly transmittable virus which causes the novel coronavirus disease (COVID-19). Monocyte distribution width (MDW) is an in-vitro hematological ... -
N6-Acetyl-L-Lysine and p-Cresol as Key Metabolites in the Pathogenesis of COVID-19 in Obese Patients
Jalaleddine, Nour; Hachim, Mahmood Yaseen; Senok, Abiola; Kandasamy, Richard K; Al Heialy, Saba (2022)Abstract: Despite the growing number of the vaccinated population, COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global health burden. Obesity, a metabolic syndrome affecting ... -
Novel Markers in Pediatric Acute Lymphoid Leukemia: The Role of ADAM6 in B Cell Leukemia
Alsuwaidi, Laila; Hachim, Mahmood Yaseen; Senok, Abiola (2021)Background: The extensive genetic heterogeneity found in the B cell precursor acute lymphoblastic leukemia (BCP-ALL) subtype of childhood ALL represents a potential repository of biomarkers. To explore this potential, ... -
Omics and Male Infertility: Highlighting the Application of Transcriptomic Data
Omolaoye, Temidayo S.; Kandasamy, Richard K; Hachim, Mahmood Yaseen; Du Plessis, Stefan; Omolaoye, Victor A (2022)Abstract: Male infertility is a multifaceted disorder affecting approximately 50% of male partners in infertile couples. Over the years, male infertility has been diagnosed mainly through semen analysis, hormone evaluations, ... -
Phytic Acid: Properties and Potential Applications in Dentistry
Nassar, Rania; Hachim, Mahmood Yaseen (2021)Abstract: Inositol hexaphosphate (IP6) is the most abundant inositol phosphate in nature and an essential molecule for different biological functions. IP6 has a unique structure granting it distinctive properties; a high ... -
Regulation of Angiotensin- Converting Enzyme 2 in Obesity: Implications for COVID-19
Al Heialy, Saba; Hachim, Mahmood Yaseen; Senok, Abiola; Tayoun, Ahmad Abou; Alsheikh-Ali, Alawi (2020)Abstract: The ongoing COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Age, smoking, obesity, and chronic diseases such as cardiovascular disease and diabetes have been described as risk factors for severe ... -
The Role of Systems Biology in Deciphering Asthma Heterogeneity
Hachim, Mahmood Yaseen; Alqutami, Fatma; Al Heialy, Saba (2022)Abstract: Asthma is one of the most common and lifelong and chronic inflammatory diseases characterized by inflammation, bronchial hyperresponsiveness, and airway obstruction episodes. It is a heterogeneous disease of ... -
Salivary microRNA 155, 146a/b and 203: A pilot study for potentially non-invasive diagnostic biomarkers of periodontitis and diabetes mellitus
Hachim, Mahmood Yaseen (2020)Abstract: Dysregulated expression of MicroRNAs (miRNAs) plays substantial role in the initiation and progression of both diabetes and periodontitis. The aim of the present study was to validate four miRNAs in saliva as ... -
Simulated Microgravity Influences Immunity-Related Biomarkers in Lung Cancer
Baghoum, Hend; Alahmed, Hend; Hachim, Mahmood Yaseen; Senok, Abiola; Jalaleddine, Nour; Al Heialy, Saba (2022-12)Abstract: Microgravity is a novel strategy that may serve as a complementary tool to develop future cancer therapies. In lung cancer, the influence of microgravity on cellular processes and the migratory capacity of cells ... -
Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19
Nassir, Nasna; Tambi, Richa; Bankapur, Asma; Al Heialy, Saba; Karuvantevida, Noushad; Zehra, Binte; Begum, Ghausia; Hameid, Reem Abdel; Ahmed, Awab; Shabestari, Seyed Ali Safizadeh; Kandasamy, Richard K; Loney, Tom; Tayoun, Ahmad Abou; Nowotny, Norbert; Hachim, Mahmood Yaseen; Berdiev, Bakhrom; Alsheikh-Ali, Alawi; Uddin, Mohammed (2021)Summary: Understanding host cell heterogeneity is critical for unraveling disease mechanism. Utilizing large-scale single-cell transcriptomics, we analyzed multiple tissue specimens from patients with life-threatening ... -
Understanding the Role of Innate Immune Cells and Identifying Genes in Breast Cancer Microenvironment
Hachim, Mahmood Yaseen (2020)Abstract: The innate immune system is the first line of defense against invading pathogens and has a major role in clearing transformed cells, besides its essential role in activating the adaptive immune system. Macrophages, ... -
Using publicly available datasets to identify population-based transcriptomic landscape contributing to the aggressiveness of breast cancer in young women
Tabbal, Marah; Hachim, Mahmood Yaseen; Jan, Reem Kais; Adrian, Thomas E (2023)Introduction: Although the risk of breast cancer increases with advancing age, some regions have larger number of young breast cancer patients (≤45 years old), such as the Middle East, Eastern Asia, and North Africa, ... -
Using publicly available transcriptomic data to identify mechanistic and diagnostic biomarkers in azoospermia and overall male infertility
Omolaoye, Temidayo S.; Hachim, Mahmood Yaseen; Du Plessis, Stefan (2022)Abstract Azoospermia, which is the absence of spermatozoa in an ejaculate occurring due to defects in sperm production, or the obstruction of the reproductive tract, afects about 1% of all men and is prevalent in up to ... -
Vitamin D Regulates the Expression of Glucocorticoid Receptors in Blood of Severe Asthmatic Patients
Heialy, Saba Al; Hachim, Mahmood Yaseen (2021)Purpose: Vitamin D (VitD) deficiency is a significant public health concern in many areas around the globe and has been associated with many immune-mediated diseases, including asthma. Severe asthma has been linked to a ... -
Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts
Hachim, Mahmood Yaseen; Al Heialy, Saba (2021)Abstract: Both canonical and non-canonical Wnt signaling pathway alterations have been documented in pulmonary disease pathogenesis and progression; therefore, they can be an attractive target for pharmaceutical management ...