Browsing by Author "Al Heialy, Saba"
Now showing items 21-31 of 31
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N6-Acetyl-L-Lysine and p-Cresol as Key Metabolites in the Pathogenesis of COVID-19 in Obese Patients
Jalaleddine, Nour; Hachim, Mahmood Yaseen; Senok, Abiola; Kandasamy, Richard K; Al Heialy, Saba (2022)Abstract: Despite the growing number of the vaccinated population, COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global health burden. Obesity, a metabolic syndrome affecting ... -
Recent advances in the immunopathogenesis of severe asthma
Al Heialy, Saba (2022)Abstract: Severe asthma is a heterogeneous disease encompassing different phenotypes and endotypes. Although patients with severe asthma constitute a small proportion of the total population with asthma, they largely ... -
Recent advances in vitamin D implications in chronic respiratory diseases
Jalaleddine, Nour; Al Heialy, Saba (2022)Abstract: Chronic airway inflammatory and infectious respiratory diseases are the most common medical respiratory conditions, associated with significant morbidity and mortality. Vitamin D (1,25(OH)2D3) deficiency has ... -
Regulation of Angiotensin- Converting Enzyme 2 in Obesity: Implications for COVID-19
Al Heialy, Saba; Hachim, Mahmood Yaseen; Senok, Abiola; Tayoun, Ahmad Abou; Alsheikh-Ali, Alawi (2020)Abstract: The ongoing COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Age, smoking, obesity, and chronic diseases such as cardiovascular disease and diabetes have been described as risk factors for severe ... -
A review of mass spectrometry-based analyses to understand COVID-19 convalescent plasma mechanisms of action
Al Heialy, Saba (2022-07)Abstract: The spread of coronavirus disease 2019 (COVID-19) viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a worldwide pandemic claiming several thousands of lives ... -
The Role of Systems Biology in Deciphering Asthma Heterogeneity
Hachim, Mahmood Yaseen; Alqutami, Fatma; Al Heialy, Saba (2022)Abstract: Asthma is one of the most common and lifelong and chronic inflammatory diseases characterized by inflammation, bronchial hyperresponsiveness, and airway obstruction episodes. It is a heterogeneous disease of ... -
Saliva as an Alternative Specimen for Molecular COVID-19 Testing in Community Settings and Population-Based Screening
Senok, Abiola; Alsuwaidi, Hanan; Han, Aaron; Al Heialy, Saba; Loney, Tom; Alsheikh-Ali, Alawi (2020)Purpose: With the easing of restriction measures, repeated community-based sampling for tracking new COVID-19 infections is anticipated for the next 6 to 12 months. A non-invasive, self-collected specimen like saliva ... -
Simulated Microgravity Influences Immunity-Related Biomarkers in Lung Cancer
Baghoum, Hend; Alahmed, Hend; Hachim, Mahmood Yaseen; Senok, Abiola; Jalaleddine, Nour; Al Heialy, Saba (2022-12)Abstract: Microgravity is a novel strategy that may serve as a complementary tool to develop future cancer therapies. In lung cancer, the influence of microgravity on cellular processes and the migratory capacity of cells ... -
Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19
Nassir, Nasna; Tambi, Richa; Bankapur, Asma; Al Heialy, Saba; Karuvantevida, Noushad; Zehra, Binte; Begum, Ghausia; Hameid, Reem Abdel; Ahmed, Awab; Shabestari, Seyed Ali Safizadeh; Kandasamy, Richard K; Loney, Tom; Tayoun, Ahmad Abou; Nowotny, Norbert; Hachim, Mahmood Yaseen; Berdiev, Bakhrom; Alsheikh-Ali, Alawi; Uddin, Mohammed (2021)Summary: Understanding host cell heterogeneity is critical for unraveling disease mechanism. Utilizing large-scale single-cell transcriptomics, we analyzed multiple tissue specimens from patients with life-threatening ... -
Use of simulation in teaching haematological aspects to undergraduate medical students improves student’s knowledge related to the taught theoretical underpinnings
Alsuwaidi, Laila; Hassan Khamis, Amar; Al Heialy, Saba (2021)Background: Simulation is an educational method which has several modalities and applications. In the last few decades Simulation-Based Medical Education (SBME) has become a significant influence in medical education. ... -
Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts
Hachim, Mahmood Yaseen; Al Heialy, Saba (2021)Abstract: Both canonical and non-canonical Wnt signaling pathway alterations have been documented in pulmonary disease pathogenesis and progression; therefore, they can be an attractive target for pharmaceutical management ...