MBRU Knowledge Repository: Recent submissions
Now showing items 1121-1140 of 1430
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Consent and capacity: issues for paediatric anaesthesia
(2020)Abstract: Learning objectives: By reading this article, you should be able to: • Describe the assessment of mental capacity. • Explain what is meant by the term ‘Gillick competence’. • Appreciate the current legal ... -
Shock Index in Patients Presenting With Acute Heart Failure: A Multicenter Multinational Observational Study
(2019-06)Abstract: Shock index (SI) has a prognostic role in coronary heart disease; however, data on acute heart failure (AHF) are lacking. We evaluated the predictive values of SI in patients with AHF. Data were retrospectively ... -
Applications and Challenges of Implementing Artificial Intelligencein Medical Education: Integrative Review
(2019-05)Background: Since the advent of artificial intelligence (AI) in 1955, the applications of AI have increased over the years within a rapidly changing digital landscape where public expectations are on the rise, fed by ... -
Use of real-world evidence for healthcare decision-making in the Middle East: practical considerations and future directions
(2019)Introduction: Real-world evidence (RWE) is increasingly being used in coverage, reimbursement and formulary decisions for medicines globally. Areas covered: The Middle East (ME) region is significantly behind in ... -
Premature Myocardial Infarction in the Middle East and North Africa: Rationale for the Gulf PREVENT Study
(2019-05)Abstract: The Middle East and North Africa (MENA) region has a high burden of morbidity and mortality due to premature ( 55 years in men; 65 years in women) myocardial infarction (MI) and acute coronary syndrome (ACS). ... -
WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to solar ultraviolet radiation and of the effect of occupational exposure to solar ultraviolet radiation on melanoma and non-melanoma skin cancer
(2019-02-18)Background: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO ... -
Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1
(2019-05-10)Background: A newly developed drug trastuzumab emtansine (T-DM1) has improved the survival of breast cancer (BC) patients. Despite an impressive initial clinical response, a subgroup of patient develop resistance and ... -
Denial in Cancer—Salutary or Deleterious
(2019-04)Abstract: Cancer, in common with other life-threatening or life-modifying illnesses, evokes strong psycho-emotional re-actions from patients, their families, and society [1]. Denial is one of the significant reactions ... -
Expanding the neurodevelopmental phenotypes of individuals with de novo KMT2A variants.
(2019-04-26)Abstract: De novo loss-of-function (LoF) variants in theKMT2Agene are associated with Wiedemann−Steiner Syndrome (WSS). Recently, de novo KMT2 Avariants have been identified in sequencing studies of cohorts of individuals ... -
Mosquito biodiversity and mosquito-borne viruses in the United Arab Emirates
(2019-04-03)Background: In the last 50 years, the United Arab Emirates (UAE) has experienced rapid population growth and urbanization. Urbanization is known to influence biodiversity, and there appears to be a link between the emergence ... -
Action of 1,25(OH)2D3 on Human Asthmatic Bronchial Fibroblasts: Implications for Airway Remodeling in Asthma
(2020)Background: Airway fibroblasts are major contributors to the histopathological feature of airway remodeling in asthma by their implication in the cell invasiveness and profibrogenic secretory phenotype observed in ... -
Clinical presentation and outcomes of peripartum cardiomyopathy in the Middle East: a cohort from seven Arab countries
(2020)Aims: Published data on the clinical presentation of peripartum cardiomyopathy (PPCM) are very limited particularly from the Middle East. The aim of this study was to examine the clinical presentation, management, and ... -
C-C chemokine receptor type 5 links COVID-19, rheumatoid arthritis, and Hydroxychloroquine: in silico analysis
(2020)Abstract: Patients with rheumatoid arthritis (RA) represent one of the fragile patient groups that might be susceptible to the critical form of the coronavirus disease − 19 (COVID-19). On the other side, RA patients have ... -
2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales
(2020)Abstract: In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. At the genus rank, 20 new ... -
High-Intensity Interval Training Decreases Muscle Sympathetic Nerve Activity in Men With Essential Hypertension and in Normotensive Controls
(2020)Abstract: Exercise training is a cornerstone in reducing blood pressure (BP) and muscle sympathetic nerve activity (MSNA) in individuals with essential hypertension. Highintensity interval training (HIIT) has been shown ... -
Effect of bronchial thermoplasty on structural changes and inflammatory mediators in the airways of subjects with severe asthma
(2019-03-20)Background: Bronchial thermoplasty (BT) is a novel technique used in the treatment of subjects with severe refractory asthma. Radio frequency is provided to airway walls during bronchoscopy in order to reduce airway ... -
Increasing Completion Rate and Benefits of Checklists: Prospective Evaluation of Surgical Safety Checklists With Smart Glasses
(2019)Background: Studies have demonstrated that surgical safety checklists (SSCs) can significantly reduce surgical complications and mortality rates. Such lists rely on traditional posters or paper, and their contents are ... -
WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to solar ultraviolet radiation and of the effect of occupational exposure to solar ultraviolet radiation on cataract
(2019-02-06)Background: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO ... -
Taxonomy of the order Mononegavirales: second update 2018.
(2019)Abstract: In October 2018, the order Mononegavirales was amended by the establishment of three new families and three new genera, abolishment of two genera, and creation of 28 novel species. This article presents the ... -
Circadian Rhythm and ST-Segment Elevation Myocardial Infarction: Insights From the Third Gulf Registry of Acute Coronary Events (Gulf RACE-3Ps)
(2019-04)Abstract: Circadian rhythms have been identified in multiple physiological processes that may affect cardiovascular diseases, yet little is known about the impact of circadian rhythm on acute ST-segment elevation myocardial ...