MBRU Knowledge Repository: Recent submissions
Now showing items 1081-1100 of 1430
-
Impact of Recurrent Miscarriage on Maternal Outcomes in Subsequent Pregnancy: The Mutaba’ah Study
(2020)Purpose: To estimate the prevalence of recurrent miscarriage (RM) and investigate the association between RM and adverse maternal outcomes in subsequent pregnancies. Participants and Methods: This is an interim ... -
Combination of obesity and co-morbidities leads to unfavorable outcomes in COVID-19 patients
(2020)Objective: Obesity has been described as a significant independent risk factors of COVID-19. We aimed to study the association between obesity, co-morbidities and clinical outcomes of COVID-19. Methods: Clinical ... -
YY1 directly interacts with myocardin to repress the triad myocardin/SRF/CArG box‑mediated smooth muscle gene transcription during smooth muscle phenotypic modulation
(2020)Summary : Yang 1 (YY1) regulates gene transcription in a variety of biological processes. In this study, we aim to determine the role of YY1 in vascular smooth muscle cell (VSMC) phenotypic modulation both in vivo and ... -
Clinical Characteristics and Outcomes of Patients With Diabetes Admitted for COVID-19 Treatment in Dubai: Single-Centre Cross-Sectional Study
(2020)Background: Recent studies have shown that diabetes is a major risk factor that contributes to the severity of COVID-19 and resulting mortality. Poor glycemic control is also associated with poor patient outcomes (eg, ... -
Harmonized definition of occupational burnout: A systematic review, semantic analysis, and Delphi consensus in 29 countries
(2020)Objective : A consensual definition of occupational burnout is currently lacking. We aimed to harmonize the definition of occupational burnout as a health outcome in medical research and reach a consensus on this definition ... -
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
(2020)Introduction: Clinical outcomes of human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus disease 2019 (COVID-19). Epidemiological studies have ... -
M1 Polarization Markers Are Upregulated in Basal-Like Breast Cancer Molecular Subtype and Associated With Favorable Patient Outcome
(2020)Background: Breast cancer heterogeneity is an essential element that plays a role in the therapy response variability and the patient’s outcome. This highlights the need for more precise subtyping methods that focus not ... -
Enhanced mitophagy in bronchial fibroblasts from severe asthmatic patients
(2020)Background: Sub-epithelial fibrosis is a characteristic feature of airway remodeling in asthma which correlates with disease severity. Current asthma medications are ineffective in treating fibrosis. In this study, we ... -
SARS-COV-2 (Covid-19) and male fertility: Where are we?
(2020)Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS COV-2), a single-stranded RNA virus, was found to be the causal agent of the disease called coronavirus disease. During December 2019, China informed the ... -
Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection
(2020)Abstract: The immune system is tightly regulated by the activity of stimulatory and inhibitory immune receptors. This immune homeostasis is usually disturbed during chronic viral infection. Using publicly available ... -
Adoption of the ADA/EASD guidelines in 10 Eastern and Southern European countries: Physician survey and good clinical practice recommendations from an international expert panel
(2020)Abstract: The aim of the present study was to assess the adoption of the ADA/EASD guidelines in a convenience sample of physicians from Eastern and Southern Europe, the barriers to the implementation of these guidelines ... -
BMC health services research title: the 2020 blast in the port of Beirut: can the Lebanese health system “build back better”?
(2020)Abstract: The August 2020 explosion in Lebanon resulted in casualties, injuries, and a great number of internally displaced persons. The blast occurred during an economically and politically complex time in the country. ... -
A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner
(2020)Abstract: Cytoplasmic dynein-1 (dynein) is the motor responsible for most retrograde transport of cargoes along microtubules in eukaryotic cells, including organelles, mRNA and viruses. Cargo selectivity and activation ... -
A profession in danger: Stakeholders’ perspectives on supporting the pharmacy profession in Lebanon
(2020)Background: Lebanon boosts one of the highest pharmacists to population ratios globally (20.3/10,000). Yet, workforce analysis elicited serious concerns with the distribution, practice environments and regulation of ... -
Molecular Basis of Cardiac and Vascular Injuries Associated With COVID-19
(2020)Background: Coronavirus disease 2019 (COVID-19) is a viral respiratory illness caused by the novel coronavirus SARS-CoV-2. The presence of the pre-existing cardiac disease is associated with an increased likelihood of ... -
Acute cardiac injury is associated with adverse outcomes, including mortality in COVID-19 patients
(2020)Abstract: Objectives: To evaluate acute cardiac injury in COVID-19 patients and its association with adverse outcomes including mortality in the United Arab Emirates (UAE) population. Methods: A retrospective study ... -
Blood and Salivary Amphiregulin Levels as Biomarkers for Asthma
(2020)Background: Amphiregulin (AREG) expression in asthmatic airways and sputum was shown to increase and correlate with asthma. However, no studies were carried out to evaluate the AREG level in blood and saliva of asthmatic ... -
Diabetes and carotid artery disease: a narrative review
(2020)Abstract: Diabetes mellitus (DM) has been linked to an increased prevalence and severity of carotid artery disease, as well as polyvascular disease. Carotid disease is also associated with obesity and abnormal peri-organ ... -
Human Dorsal Root Ganglion Stimulation Reduces Sympathetic Outflow and Long-Term Blood Pressure
(2020)Summary: This study hypothesized that dorsal root ganglion (DRG) stimulation would reduce sympathetic nerve activity and would alter hemodynamic variables. This study directly recorded muscle sympathetic nerve activity ... -
Genotyping of methicillin resistant Staphylococcus aureus from the United Arab Emirates
(2020)Abstract: Reports from Arabian Gulf countries have demonstrated emergence of novel methicillin resistant Staphylococcus aureus (MRSA) strains. To address the lack of data from the United Arab Emirates (UAE), genetic ...