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dc.contributor.authorMacefield, Vaughan G.
dc.date.accessioned2021-05-20T04:54:47Z
dc.date.available2021-05-20T04:54:47Z
dc.date.issued2018-01
dc.identifier.other204-2018.19
dc.identifier.urihttps://repository.mbru.ac.ae/handle/1/255
dc.description.abstractAbstract: Recurrent thalamocortical connections are integral to the generation of brain rhythms and it is thought that the inhibitory action of the thalamic reticular nucleus is critical in setting these rhythms. Our work and others’ has suggested that chronic pain that develops following nerve injury, that is, neuropathic pain, results from altered thalamocortical rhythm, although whether thisdysrhythmia is associated with thalamic inhibitory function remains unknown. In this investigation,we used electroencephalography and magnetic resonance spectroscopy to investigate cortical power and thalamic GABAergic concentration in 20 patients with neuropathic pain and 20pain-free controls. First, we found thalamocortical dysrhythmia in chronic orofacial neuropathic pain; patients displayed greater power than controls over the 4–25 Hz frequency range, most marked in the theta and low alpha bands. Furthermore, sensorimotor cortex displayed a strong positive correlation between cortical power and pain intensity. Interestingly, we found no difference in thalamic GABA concentration between pain subjects and control subjects. However, we demonstrated significant linear relationships between thalamic GABA concentration and enhanced cortical power in pain subjects but not controls. Whilst the difference in relationship between thalamic GABA concentration and resting brain rhythm between chronic pain and control subjects does not prove a cause and effect link, it is consistent with a role for thalamic inhibitory neuro-transmitter release, possibly from the thalamic reticular nucleus, in altered brain rhythms in individuals with chronic neuropathic pain.en_US
dc.language.isoenen_US
dc.subjectChronic painen_US
dc.subjectElectroencephalographen_US
dc.subjectGABAen_US
dc.subjectThalamocortical rhythmen_US
dc.titleThe relationship between thalamic GABA content and resting cortical rhythm in neuropathic painen_US
dc.typeArticleen_US


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