Show simple item record

dc.contributor.authorAlsheikh-Ali, Alawi
dc.date.accessioned2021-03-01T07:39:12Z
dc.date.available2021-03-01T07:39:12Z
dc.date.issued2017-05
dc.identifier.other204-2017.14
dc.identifier.urihttps://repository.mbru.ac.ae/handle/1/171
dc.description.abstractIntroduction: Triggers and ICD interventions of ventricular arrhythmias in patients with hypertrophic cardiomyopathy (HCM) offer insight into mechanisms and treatment. Methods and Results: Intracardiac ICD electrograms from 71 HCM patients in the HCM I and II studies were analyzed by three individuals. Rhythms were defined as VF (polymorphic ventricular arrhythmia), VT (monomorphic ventricular tachycardia), and ventricular flutter (VFL; VT 240 bpm). Physical activity and rhythm preceding the arrhythmia were ascertained. Of 149 arrhythmias, VF was present in 74, VT in 57, and VFL in 18. In those whose activity was known, moderate or intense physical activity was associated with over 50% of the tachycardias (57 of 111). Rhythms preceding ventricular arrhythmias were often sinus tachycardia (49 of 149; 33%) or rapid atrial fibrillation (7 of 149; 5%). VF and VFL were more likely preceded by supraventricular rhythms >100 bpm (30 of 68 with VF; 44%; 12 of 16 with VFL 75%, vs. 14 of 50 with VT 28%; P = 0.001). Antitachycardia pacing (ATP) was successful in 39 of 53 (74%). Multiple shocks were more often required to terminate VFL (10 of 18; 56%) compared to VF (10 of 72; 14%) and VT (2 of 25; 8%; P < 0.0001). Of arrhythmias requiring more than one shock to terminate, 16 of 22 were preceded by sinus tachycardia and/or moderate or extreme physical activity. Conclusions: Rapid supraventricular rhythms, and at leastmoderate activity, frequently precede VT and VF, and when they occur in these situations often require multiple ICD shocks to restore sinus rhythm. ATP is successful in terminating VT and VFL, and should be a programmed in all HCM patients with ICDs.en_US
dc.language.isoenen_US
dc.subjectAntitachycardia pacingen_US
dc.subjectAthletesen_US
dc.subjectAtrial fibrillationen_US
dc.subjectExerciseen_US
dc.subjectHypertrophic cardiomyopathyen_US
dc.subjectImplantable cardioverter defibrillatorsen_US
dc.subjectVentricular fibtillationen_US
dc.subjectVentricular tachycardiaen_US
dc.titleVentricular Tachyarrhythmias in PatientsWith Hypertrophic Cardiomyopathy and Defibrillators: Triggers, Treatment, and Implicationsen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record