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Denial in Cancer—Salutary or Deleterious
(2019-04)
Abstract:
Cancer, in common with other life-threatening or life-modifying illnesses, evokes strong psycho-emotional re-actions from patients, their families, and society [1]. Denial is one of the significant reactions ...
1,2,3-Triazolyl ester of ketorolac (15K), a potent PAK1 blocker, inhibits both growth and metastasis of orthotopic human pancreatic cancer xenografts in mice
(2019)
More than 90% of human pancreatic cancers carry the oncogenic mutant of Ki-RAS and their growth depends on its downstream kinase PAK1, mainly because PAK1 blocks the apoptosis of cancer cells selectively. We developed a ...