Publication:
Incidence of Persistence and Recurrence of Differentiated Thyroid Cancer in Post-surgical Cases From a Tertiary Care Hospital in Dubai, United Arab Emirates

dc.contributor.authorAhmad, Donia
dc.date.accessioned2024-10-10T08:05:01Z
dc.date.available2024-10-10T08:05:01Z
dc.date.issued2024
dc.description.abstractAbstract Background: Despite the excellent prognosis of differentiated thyroid carcinoma, recurrence remains a major concern. However, the persistence of thyroid cancer post-thyroidectomy is not uncommon. We aimed to characterise patients who underwent re-operative surgery for differentiated thyroid carcinoma and analyse the percentage of re-operations that truly were for "recurrent" disease versus the management of persistent disease. Methods: We conducted a retrospective review of the hospital database, analysing patients who visited the nuclear medicine department at Mediclinic City Hospital, a tertiary care hospital in Dubai, United Arab Emirates, between 2015 and 2022. The study included patients with differentiated thyroid carcinoma who underwent re-operations after total thyroidectomy. Recurrence was defined as the development of disease after a patient had undetectable thyroglobulin and negative radiological scans within one year of the first surgery. Cases were categorised as "recurrent", "persistent", or "unable to classify" in the event of missing data. Results: Out of 836 patients diagnosed with differentiated thyroid carcinoma who visited the nuclear medicine department, 71 underwent re-operations. The mean age of these patients was 44.4 years (CI 41.7-47.0), of whom 78.9% were females. Almost half (46.5%) underwent re-operations within the first year, and 98.6% were diagnosed with papillary thyroid carcinoma. We were able to classify 63.4% of cases (n=45) as persistent disease, while 24 cases were categorised as "unable to classify". Only two cases met the criteria for recurrent disease. Conclusion: The majority of cases previously classified as "recurrent" in differentiated thyroid carcinoma were found to be a persistent disease, possibly indicating inadequate therapy. Further research may be required to explore the reasons behind this eye-opening rate of disease persistence. This highlights an area for improvement in the management and future outcomes of differentiated thyroid carcinoma patients.en_US
dc.identifier.other204-2024.93
dc.identifier.urihttps://repository.mbru.ac.ae/handle/1/1585
dc.language.isoenen_US
dc.subjectReoperationen_US
dc.subjectAnti-thyroglobulin antibodiesen_US
dc.subjectThyroglobulinen_US
dc.subjectNuclear medicineen_US
dc.subjectThyroid canceren_US
dc.subjectRecurrent thyroid canceren_US
dc.subjectThyroidectomyen_US
dc.subjectRadioactive iodine therapyen_US
dc.subjectPapillary cancer of thyroiden_US
dc.subjectDifferentiated thyroid canceren_US
dc.titleIncidence of Persistence and Recurrence of Differentiated Thyroid Cancer in Post-surgical Cases From a Tertiary Care Hospital in Dubai, United Arab Emiratesen_US
dc.typeArticleen_US
dspace.entity.typePublicationen_US

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