Persistent Menorrhagia and Hemorrhagic Ovarian Cyst in a Patient With Bernard-Soulier Syndrome: A Case Report

Abstract

Bernard-Soulier syndrome (BSS) is a rare qualitative condition of platelets wherein deficiency of platelet surface glycoproteins (GP) Ib, IX, and V forms the Ib-IX-V complex, leading to impaired hemostasis. Although it commonly presents as prolonged bleeding in general, women in the reproductive phase report additional complications during menstruation, pregnancy, and childbirth. In women of reproductive age, menorrhagia is a frequent complaint. It is reported that secondary to hormonal and other causes, hemostatic disorders are present in a substantial proportion of women presenting with persistent menorrhagia. Women with bleeding disorders also hold an additional risk of developing complications like hemorrhagic corpus luteum. While corpus luteum rupture may go unnoticed in healthy women, it can cause life-threatening intraperitoneal hemorrhage in women with bleeding disorders. This report presents a case of a young woman with BSS who developed menorrhagia against the backdrop of a hemorrhagic ovarian cyst. Owing to the rarity of reported management of hemorrhagic cysts with underlying BSS, this report aimed to potentially serve as a guide in facilitating decision-making for physicians.