Publication: Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family Study
dc.contributor.author | Bayoumi, Riad | |
dc.date.accessioned | 2021-03-29T06:48:20Z | |
dc.date.available | 2021-03-29T06:48:20Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Objective: To more precisely and comprehensively estimate the genetic and environmental correlations between various indices of obesity and BP. Methods: We estimated heritability and genetic correlations of obesity indices with BP in the Oman family study (n = 1231). Ambulatory and office beat-to-beat BP was measured and mean values for SBP and DBP during daytime, sleep, 24-h and 10 min at rest were calculated. Different indices were used to quantify obesity and fat distribution: BMI, percentage of body fat (%BF), waist circumference and waist-to-height ratio (WHtR). SOLAR software was used to perform univariate and bivariate quantitative genetic analyses adjusting for age, age2, sex, age-sex and age2-sex interactions. Results: Heritabilities of BP ranged from 30.2 to 38.2% for ambulatory daytime, 16.8–21.4% for sleeping time, 32.1–40.4% for 24-h and 22–24.4% for office beat-to-beat measurements. Heritabilities for obesity indices were 67.8% for BMI, 52.2% for %BF, 37.3% for waist circumference and 37.9% for WHtR. All obesity measures had consistently positive phenotypic correlations with ambulatory and office beat-to-beat SBP and DBP (r-range: 0.14–0.32). Genetic correlations of obesity indices with SBP and DBP were higher than environmental correlations (rG: 0.16–0.50; rE: 0.01–0.31). Conclusion: The considerable genetic overlap between a variety of obesity indices and both ambulatory and office beat-to-beat BP highlights the relevance of pleiotropic genes. Future GWAS analyses should discover the specific genes both influencing obesity indices and BP to help unravel their shared genetic background. | en_US |
dc.identifier.other | 204-2020.14 | |
dc.identifier.uri | https://repository.mbru.ac.ae/handle/1/226 | |
dc.language.iso | en | en_US |
dc.subject | Ambulatory blood pressure; | en_US |
dc.subject | Correlations | en_US |
dc.subject | Heritability | en_US |
dc.subject | Obesity indices | en_US |
dc.title | Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family Study | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | en_US |