Publication:
Detection of OXA-23, GES-11 and NDM-1 among carbapenem-resistant Acinetobacter baumannii in Dubai: A preliminary study

dc.contributor.authorHan, Aaron
dc.date.accessioned2022-02-07T09:06:14Z
dc.date.available2022-02-07T09:06:14Z
dc.date.issued2021
dc.description.abstractLetter to Editor: Acinetobacter baumannii is a Gram-negative organism that has become a significant offender in health-care facilities, with the worldwide spread of carbapenem-resistant Acinetobacter baumannii (CRAB) significantly debilitating treatment options. Acquired carbapenemases of Ambler class D, or oxacillinases, namely OXA23-like, OXA-24-like, OXA-58-like, OXA-143-like and OXA-235-like groups, have been largely described in CRAB. Non-OXA carbapenemases are also acquired by A. baumannii, including metallo-β-lactamases of Ambler class B, such as the NDM-group, as well as Ambler class A carbapenemases, KPC and GES [1]. Intrinsically, two β-lactam hydrolysing enzyme groups occur in CRAB, OXA-51 and Acinetobacter-derived cephalosporinases (ADCs). While these two intrinsic enzyme categories secure weak carbapenem hydrolysis, acquisition of insertion sequence (IS) elements such as ISAba1 upstream of blaOXA-51 and blaADC may lead to enhanced expression, increasing resistance to cephalosporins, but only minimally to carbapenems. The existence of ISAba1 upstream of acquired blaOXA-23 enhances expression, resulting in higher carbapenem hydrolysis.en_US
dc.identifier.other204-2021.99
dc.identifier.urihttps://repository.mbru.ac.ae/handle/1/803
dc.language.isoenen_US
dc.subjectCarbapenem-resistant Acinetobacter baumanniien_US
dc.subjectDubaien_US
dc.subjectStudyen_US
dc.subjectOXA-23en_US
dc.subjectGES-11en_US
dc.subjectNDM-1en_US
dc.titleDetection of OXA-23, GES-11 and NDM-1 among carbapenem-resistant Acinetobacter baumannii in Dubai: A preliminary studyen_US
dc.typeArticleen_US
dspace.entity.typePublicationen_US

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