Publication: Detection of OXA-23, GES-11 and NDM-1 among carbapenem-resistant Acinetobacter baumannii in Dubai: A preliminary study
dc.contributor.author | Han, Aaron | |
dc.date.accessioned | 2022-02-07T09:06:14Z | |
dc.date.available | 2022-02-07T09:06:14Z | |
dc.date.issued | 2021 | |
dc.description.abstract | Letter to Editor: Acinetobacter baumannii is a Gram-negative organism that has become a significant offender in health-care facilities, with the worldwide spread of carbapenem-resistant Acinetobacter baumannii (CRAB) significantly debilitating treatment options. Acquired carbapenemases of Ambler class D, or oxacillinases, namely OXA23-like, OXA-24-like, OXA-58-like, OXA-143-like and OXA-235-like groups, have been largely described in CRAB. Non-OXA carbapenemases are also acquired by A. baumannii, including metallo-β-lactamases of Ambler class B, such as the NDM-group, as well as Ambler class A carbapenemases, KPC and GES [1]. Intrinsically, two β-lactam hydrolysing enzyme groups occur in CRAB, OXA-51 and Acinetobacter-derived cephalosporinases (ADCs). While these two intrinsic enzyme categories secure weak carbapenem hydrolysis, acquisition of insertion sequence (IS) elements such as ISAba1 upstream of blaOXA-51 and blaADC may lead to enhanced expression, increasing resistance to cephalosporins, but only minimally to carbapenems. The existence of ISAba1 upstream of acquired blaOXA-23 enhances expression, resulting in higher carbapenem hydrolysis. | en_US |
dc.identifier.other | 204-2021.99 | |
dc.identifier.uri | https://repository.mbru.ac.ae/handle/1/803 | |
dc.language.iso | en | en_US |
dc.subject | Carbapenem-resistant Acinetobacter baumannii | en_US |
dc.subject | Dubai | en_US |
dc.subject | Study | en_US |
dc.subject | OXA-23 | en_US |
dc.subject | GES-11 | en_US |
dc.subject | NDM-1 | en_US |
dc.title | Detection of OXA-23, GES-11 and NDM-1 among carbapenem-resistant Acinetobacter baumannii in Dubai: A preliminary study | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | en_US |