Browsing by Subject "Neuroblastoma"
Now showing items 1-5 of 5
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Elevated ASCL1 activity creates de novo regulatory elements associated with neuronal diferentiation
(2022)Background: The pro-neural transcription factor ASCL1 is a master regulator of neurogenesis and a key factor necessary for the reprogramming of permissive cell types to neurons. Endogenously, ASCL1 expression is often ... -
Palbociclib releases the latent differentiation capacity of neuroblastoma cells
(2023)Abstract: Neuroblastoma is the most common extracranial solid tumor in infants, arising from developmentally stalled neural crest-derived cells. Driving tumor differentiation is a promising therapeutic approach for this ... -
The proneural transcription factor ASCL1 regulates cell proliferation and primes for differentiation in neuroblastoma
(2022)Abstract: Neuroblastoma is believed to arise from sympathetic neuroblast precursors that fail to engage the neuronal differentiation programme, but instead become locked in a pro-proliferative developmental state. ... -
Super-enhancer associated core regulatory circuits mediate susceptibility to retinoic acid in neuroblastoma cells
(2022)Abstract: Neuroblastoma is a pediatric tumour that accounts for more than 15% of cancer-related deaths in children. High-risk tumours are often difficult to treat, and patients’ survival chances are less than 50%. Retinoic ... -
Tumoral heterogeneity in neuroblastoma
(2022)Abstract: Neuroblastoma is a solid, neuroendocrine tumor with divergent clinical behavior ranging from asymptomatic to fatal. The diverse clinical presentations of neuroblastoma are directly linked to the high intra- and ...