Browsing by Subject "Cancer"
Now showing items 1-11 of 11
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1,2,3-Triazolyl ester of ketorolac (15K), a potent PAK1 blocker, inhibits both growth and metastasis of orthotopic human pancreatic cancer xenografts in mice
(2019)More than 90% of human pancreatic cancers carry the oncogenic mutant of Ki-RAS and their growth depends on its downstream kinase PAK1, mainly because PAK1 blocks the apoptosis of cancer cells selectively. We developed a ... -
Asthma severity as a contributing factor to cancer incidence: A cohort study
(2021)Background: A putative link between asthma and asthma severity with the occurrence of cancer has been suggested but has not been fully investigated. The objective of this study is to assess the incidence of all types of ... -
Denial in Cancer—Salutary or Deleterious
(2019-04)Abstract: Cancer, in common with other life-threatening or life-modifying illnesses, evokes strong psycho-emotional re-actions from patients, their families, and society [1]. Denial is one of the significant reactions ... -
Disease-Associated Regulation of Non-Coding RNAs by Resveratrol: Molecular Insights and Therapeutic Applications
(2022-07)Abstract: There have been significant advances, particularly over the last 20 years, in the identification of non-coding RNAs (ncRNAs) and their pathophysiological role in a wide range of disease states, particularly ... -
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Global evidence on occupational sun exposure and keratinocyte cancers: a systematic review
(2020)Summary: Individual studies have suggested that the association between occupational exposure to solar ultraviolet radiation (UVR) and the development of keratinocyte cancers (KCs) may only be valid in populations of ... -
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LncRNA-Associated Genetic Etiologies Are Shared between Type 2 Diabetes and Cancers in the UAE Population
(2022)Abstract: Numerous epidemiological studies place patients with T2D at a higher risk for cancer. Many risk factors, such as obesity, ageing, poor diet and low physical activity, are shared between T2D and cancer; however, ... -
Negative Effects On Cancer Care Due To COVID-19 Implications: Observations From A Cancer Center In The UAE
(2020)Abstract: In 2019, the World Health Organization declared the novel coronavirus disease (COVID-19) to be a public health emergency of international concern that rapidly escalated to pandemic status in 2020 (1). As of ... -
Repurposing drugs targeting metabolic diseases for cancer therapeutics
(2023)Introduction: Hurdles in the identification of new drugs for cancer treatment have made drug repurposing an increasingly appealing alternative. The approach involves the use of old drugs for new therapeutic purposes. It ... -
A Venomics Approach to the Identification and Characterization of Bioactive Peptides From Animal Venoms for Colorectal Cancer Therapy: Protocol for a Proof-of-Concept Study
(2021)Background: Cancer is the third leading cause of death in the United Arab Emirates (UAE), after cardiovascular diseases and accidents. In the UAE, colorectal cancer (CRC) is the first and fourth most common cancer in males ...