Browsing by Author "Jegaden, Olivier"

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Does the Addition of a Gastroepiploic Artery to Bilateral Internal Thoracic Artery Improve Survival?
(2021) Jegaden, Olivier; Hassan Khamis, Amar
Abstract: It is unclear whether the additional conduit to supplement bilateral internal thoracic arteries (BITA) influences the patient outcome in coronary surgery. This retrospective study compared long-term survival of patients undergoing left-sided BITA grafting in which the third conduit to the right coronary system (RCA) was either vein graft (SVG) or gastroepiploic artery (GEA). From 1989 to 2014, 1432 consecutive patients underwent left-sided revascularization with BITA associated with SVG (n = 599) or GEA (n = 833) to RCA. Propensity score was calculated by logistic regression model and patients were matched 1 to 1 leading to 2 groups of 320 matched patients. The primary end point was the overall mortality from any cause. GEA was used in significantly lower risk patients. The 30-day mortality was 1.6% without influence of the graft configuration. Postoperative follow-up was 13.6 § 6.6 years and was 94% complete. The significant difference in patients’ survival observed at 20 years in favor of GEA in unmatched groups (48 § 4% vs 33 § 6%, P < 0.001) was not confirmed in matched groups (41 § 7% vs 36 § 7%, P=0.112). In multivariable Cox model analysis, the conduit used to RCA did not influence the long-term survival in matched groups, like no other graft configuration or operative parameter. Only complete revascularization remained predictor of survival (P=0.016), with age (P < 0.0001), diabetes status (P=0.007), and left ventricle ejection fraction (P < 0.0001). Long-term survival in patients undergoing BITA grafting is not affected by using GEA as third arterial conduit in alternative to SVG. Further studies are necessary to assess its impact on long-term cardiac events.
Is robotic assistance an added value in minimally invasive mitral valve surgery? A meta-analysis from propensity score–matched series
(2023) Jegaden, Olivier; Mahdi, Alhaitham
Objectives: There is still ongoing debate about the benefits of robotic assistance (R-MVS) in comparison with video assistance (V-MVS) in minimally invasive mitral valve surgery. This study aims to update the current evidence. Methods: Three propensity score–matched studies published from 2011 to 2021 were included with a total of 1193 patients operated on from 2005 (R-MVS: 536, V-MVS: 657). Data regarding early mortality, postoperative event, and time-related outcomes were extracted and submitted to a meta-analysis using weighted random-effects modeling. Results: The incidence of early mortality, stroke, renal failure, conversion, atrial fibrillation, and prolonged ventilation were similar, all in the absence of heterogeneity. Reoperation for bleeding (odds ratio [OR]: 0.36, 95% confidence interval [CI] 0.16–0.81, p=0.01) and the need for blood transfusion (OR: 0.30, 95% CI, 0.20–0.56, p=0.001) were significantly lower in V-MVS group. Regarding time-related outcomes, there was evidence for important heterogeneity of treatment effect among the studies. Operative times were longer in R-MVS: differences in means were 20.7 min for cross-clamp time (95% CI, 9.07–32.3, p=0.001), 20.7 min for cardiopulmonary bypass time (95% CI, 2.5–38.9, p=0.03) and 40.2 min for total operative time (95% CI, 24.5–55.8, p < 0.001). Intensive care unit stay and hospital stay were reported in one study, and longer after R-MVS compared to V-MVS; the differences in means were 0.17 days (p=0.005) and 0.6 days (p=0.017), respectively. Total cost of both procedures was reported in an additional dedicated propensity score– matched series including 448 patients; it was 21% higher for R-MVS than for V-MVS. Conclusions: This meta-analysis showed excellent outcomes of both video and robotic techniques with low incidence of morbidity and mortality. However, there is no evidence for an added value of robotic assistance in comparison with video assistance; the drawbacks of mini access are reported higher regardless the induced over cost.
Minithoracotomy versus sternotomy in mitral valve surgery: meta-analysis from recent matched and randomized studies
(2023) Jegaden, Olivier
Background: There is still ongoing debate about the benefits of mini-thoracotomy (MTH) approach in mitral valve surgery in comparison with complete sternotomy (STER). This study aims to update the current evidence with mortality as primary end point. Methods: The MEDLINE and EMBASE databases were searched through June 2022. Two randomized studies and 16 propensity score matched studies published from 2011 to 2022 were included with a total of 12,997 patients operated on from 2005 (MTH: 6467, STER: 6530). Data regarding early mortality, stroke, reoperation for bleeding, new renal failure, new onset of atrial fibrillation, need of blood transfusion, prolonged ventilation, wound infection, time-related outcomes (cross clamp time, cardiopulmonary bypass time, ventilation time, length of intensive care unit stay, length of hospital stay), midterm mortality and reoperation, and costs were extracted and submitted to a meta-analysis using weighted random effects modeling. Results: The incidence of early mortality, stroke, reoperation for bleeding and prolonged ventilation were similar, all in the absence of heterogeneity. However, the sub-group analysis showed a significant OR in favor of MTH when robotic enhancement was used. New renal failure (OR 1.67, 95% CI 1.06–2.62, p=0.03), new onset of atrial fibrillation (OR 1.31, 95% CI 1.15–1.51, p=0.001) and the need of blood transfusion (OR 1.77, 95% CI 1.39–2.27, p=0.001) were significantly lower in MTH group. Regarding time-related outcomes, there was evidence for important heterogeneity of treatment effect among the studies. Operative times were longer in MTH: differences in means were 20.7 min for cross clamp time (95% CI 14.9–26.4, p=0.001), 36.8 min for CPB time (95% CI 29.8–43.9, p=0.001) and 37.7 min for total operative time (95% CI 19.6–55.8, p <0.001). There was no significant difference in ventilation duration; however, the differences in means showed significantly shorter ICU stay and hospital stay after MTH compared to STER: −0.6 days (95% CI −1.1/−0.21, p=0.001) and −1.88 days (95% CI −2.72/−1.05, p=0.001) respectively, leading to a significant lower hospital cost after MTH compared to STER with difference in means −4528 US$ (95% CI −8725/−326, p=0.03). The mid-term mortality was significantly higher after STER compared to MTH: OR=1.50, 1.09–2.308 (95% CI), p=0.01; the rate of mid-term reoperation was reported similar in MTH and STER: OR=0.76, 0.50–1.15 (95% CI), p=0.19. Conclusions: The present meta-analysis confirms that the MTH approach for mitral valve disease remains associated with prolonged operative times, but it is beneficial in terms of reduced postoperative complications (renal failure, atrial fibrillation, blood transfusion, wound infection), length of stay in ICU and in hospitalization, with finally a reduction in global cost. MTH approach appears associated with a significant reduction of postoperative mortality that must be confirmed by large randomized study.