Browsing by Author "Hasan, Ahmedyar"

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Early coronary angioplasty fails to lower all-cause mortality in patients with out-of-hospital cardiac arrest without ST-segment elevation: A systematic review and meta-analysis
(2024-01) Hasan, Ahmedyar
Abstract: Introduction: Out-of-hospital cardiac arrest (OHCA) is defined as the loss of functional mechanical activity of the heart in association with an absence of systemic circulation, occurring outside of a hospital. Immediate coronary angiography (CAG) with percutaneous coronary intervention is recommended for OHCA with ST-elevation. We aimed to evaluate the effect of early CAG on mortality and neurological outcomes in OHCA patients without ST-elevation. Methods: This meta-analysis and systemic review was conducted as per principles of Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) group. A protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO, Ref No. = CRD42022327833). A total of 674 studies were retrieved after scanning several databases (PubMed Central, EMBASE, Medline, and Cochrane Central Register of Controlled Trials). Results: A total of 18 studies were selected for the final analysis, including 6 randomized control trials and 12 observational studies. Statistically, there was no significant difference in primary outcome, i.e., mortality, between early and delayed CAG. In terms of the grade of neurological recovery as a secondary outcome, early and delayed CAG groups also showed no statistically significant difference. Conclusion: Early CAG has no survival benefits in patients with no ST elevations on ECG after OHCA.
Is retinopathy due to stargardt’s disease or after malaria treatment with chloroquine?
(2018-11) Hasan, Ahmedyar
Abstract: Central vision impairment associated with macular degeneration in young adults in the absence of other chronic conditions can be associated with an autosomal recessive condition known as Stargardt’s Disease (SD). One of the serious complications of long term malaria prophylaxis (LTMP) is maculopathy associated with chloroquine treatment. This complication can cause blindness as well as permanent visual impairment. Evidence suggests that the cumulative dose of LTMP should not exceed 140 g for subjects at risk of chloroquine retinopathy (CR). We present a case of macular degeneration with possible genetic inheritance associated with SD. However, presentation was associated with chloroquine treatment for malaria as a single dose of 120g over three days. Periodic screening is required since a threshold dose of chloroquine for causing toxicity in the retina has not yet been established.
Painless Footdrop in a Child with Newly Diagnosed Type 1 Diabetes Mellitus: Case Report
(2022-12) Jafari, Maryam; Hasan, Ahmedyar; Joseph, Jessie
Abstract: Diabetic neuropathy is a major cause of morbidity among diabetics, usually affecting patients with long-standing diabetes and advancing age. We present a case of atypical first clinical presentation of diabetes mellitus type 1 in a pediatric patient. A 15-year-old male patient presented to the Emergency department with complaints of right foot weakness associated with mild paresthesia of 1-week duration. There were complaints of polyuria, polydipsia and weight loss in the same timeframe. On subsequent examination, the patient exhibited signs of right-sided foot drop with weak ankle dorsiflexion and eversion accompanied by impaired sensation over the dorsum of the right foot. Lab results confirmed a diagnosis of diabetes mellitus type 1 and the patient was started on subcutaneous insulin injections. The patient's foot drop recovered within 1 month of insulin initiation. This case highlights that Type 1 diabetes mellitus can present atypically as acute onset neuropathy in pediatric patients, making it an important differential diagnosis.