Browsing by Author "Benamer, Hani T S"

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Mapping human brain cell type origin and diseases through single cell transcriptomics
(2025-10-06) Balan, Bipin; Nassir, Nasna; Berdiev, Bakhrom K; Benamer, Hani T S; Uddin, Mohammed
The human brain, a pinnacle of biological complexity, comprises a diverse array of cell types that regulate cognition and maintain neural homeostasis. Advances in single-cell transcriptomics have revolutionized neuroscience by enabling high-resolution molecular profiling, revealing unprecedented insights into cellular heterogeneity, lineage dynamics, and disease-associated states. Large-scale brain-mapping initiatives have identified numerous novel cell types, yet their functional roles in health and disease remain poorly understood. This review synthesizes current knowledge of brain cell diversity, from neurogenesis to pathological states, and highlights key gene markers that define cellular identity and function. By integrating insights from single-cell transcriptomics, we explore how cellular diversity shapes brain function and contributes to disease mechanisms, providing a foundation for future research and translational applications.
MRI-Guided Focused Ultrasound (MRgFUS) in Parkinson's Disease and Essential Tremor: Incisionless but Invasive! - A Narrative Review.
(2025-06-04) Benamer, Hani T S
Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging and promising technology for treating movement disorders, such as essential tremor and tremor-dominant Parkinson's disease. It utilises advanced ultrasound transducer emitters to condense sound waves at a precisely defined point able to target various brain areas, such as the pallidothalamic tract, thalamus, and pallidum that ameliorates some of the symptoms of Parkinson's disease and other movement disorders like dystonic and action induced tremors. we review the current status of preclinical and clinical trials clinical use, treatment outcomes and indications of Magnetic resonance-guided focused ultrasound (MRgFUS).
The first cross-sectional comparative observational study of sexual dysfunction in Emirati and non-Emirati Parkinson's disease patients (EmPark-SD) in the United Arab Emirates
(2024-11-21) Benamer, Hani T S; Loney, Tom
Sexual dysfunction (SD) is a common non-motor symptom in people with Parkinson's disease (PD) yet underreported and undertreated specifically in many ethnic PD groups because of religious, social and personal perceptions. We conducted the first single-centre cross-sectional study in the United Arab Emirates of SD in 513 consecutive patients who agreed to complete the survey questionnaires. Data was collected on SD using the Nonmotor Symptoms Scale (NMSS), Index of Erectile Function, and Female Sexual Function Index. Our results show that the non-Emirati group had higher NMSS-SD scores than the Emirati group. SD was reported independent of ethnicity, race and disease stage (p < 0.001). SD correlated with worsening quality of life (p < 0.001) and anxiety domain, especially in young PD patients (p < 0.001). Our data concludes that there is no significant difference in SD between different ethnicity groups, contrary to common perception. SD appears to be underreported in this population and needs addressing using culturally sensitive bespoke counselling.