MBRU Knowledge Repository
Knowledge Repository at Mohammed Bin Rashid University of Medicine and Health Sciences
Welcome to digital archive and research repository of Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU). MBRU Knowledge Repository is a digital service that collects, preserves, and distributes digital material. MBRU's scholarly communications including theses, faculty publications, student projects, and departmental records and publications are the key digital records available in this repository. Repositories are important tools for preserving an organization's legacy; they facilitate digital preservation and scholarly communication.
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- Library Digital Archives
- Research and Scholarly work of College of Medicine
- Dubai Health Researchers Profiles
- Research and Scholarly work of Graduate Medical Education
- Research and Scholarly work of Hamdan Bin Mohammed College of Dental Medicine
- Research and Scholarly work of Hind Bint Maktoum College of Nursing and Midwifery
- Research and Scholarly work of IoL
- Research publications of other departments
- Theses and dissertations submitted by MBRU graduate and post-graduate students.
Recent Submissions
Impact of acute alcohol intoxication and alcohol dependence on outcomes after subarachnoid hemorrhage
(2025-08-27) Kaddoura, Rachid
Background: Non-traumatic subarachnoid hemorrhage (SAH) is most commonly caused by a ruptured aneurysm. Risk factors for rupture include hypertension, smoking, and substance use, but the relationship between alcohol use and clinical outcomes after SAH is poorly understood. The objective of this population-based, longitudinal, study is to characterize the relationships between alcohol use, alcohol dependence, and adverse clinical outcomes following SAH.
Dyslipidemia Prevalence and Risk Factors in Al Ain: A Retrospective Cross-Sectional Analysis
(Elmer Press, Inc., 2025-08) Suliman, Ala
Background: Dyslipidemia, defined by abnormal lipid profiles, is a key modifiable risk factor for cardiovascular diseases (CVDs), contributing significantly to morbidity and mortality globally. Although dyslipidemia prevalence is high in the United Arab Emirates (UAE), data specific to Al Ain City remain limited. The aim of the study was to assess the prevalence of dyslipidemia and its associated risk factors among adults in Al Ain City, UAE, and to inform targeted public health strategies.
A Rare Case Report of Deep Aggressive Angiomyxoma Mimicking Bartholin’s Cyst
(Jaypee Brothers Medical Publishing, 2024-10-23) Talo, Sami; Maryum, Rida
We present a case of deep aggressive angiomyxoma (AA) of a vulval lesion. This case report is of a 32-year-old female (para 1, living 1) who presented to the gynecological outpatient department with complaints of a lump felt in her left vagina for 1 month. This was initially misdiagnosed as a Bartholin gland cyst. She underwent excision of Bartholin’s gland under anesthesia. The histopathology reported a deep AA of the vulval lesion. Despite the rarity of this condition, with only 350 cases reported so far, it is crucial to include it in the range of differential diagnoses for a pelvic mass, considering the locally aggressive characteristics of this tumor and its tendency to recur.
Combinational regenerative inductive effect of bio-adhesive hybrid hydrogels conjugated with hiPSC-derived myofibers and its derived EVs for volumetric muscle regeneration
(Elsevier BV, 2025-01) Nasr, Mahmoud Lotfi
In regenerative medicine, extracellular vesicles (EVs) possess the potential to repair injured cells by delivering modulatory factors. However, the therapeutic effect of EVs in large-scale tissue defects, which are subject to prolonged timelines for tissue architecture and functional restoration, remains poorly understood. In this study,
we introduce EVs and cell-tethering hybrid hydrogels composed of tyramine-conjugated gelatin (GelTA) that can be in-situ crosslinked with EVs derived from human induced pluripotent stem cell-derived myofibers (hiPSCmyofibers) and hiPSC-muscle precursor cells. This hybrid hydrogel sustains the release of EVs and provides a beneficial nano-topography and mechanical properties for creating a favorable extracellular matrix. Secreted EVs from the hiPSC-myofibers contain specific microRNAs, potentially improving myogenesis and angiogenesis. Herein, we demonstrate increased myogenic markers and fusion/differentiation indexes through the combinatory effects of EVs and integrin-mediated adhesions in the 3D matrix. Furthermore, we observe a unique impact of EVs, which aid in maintaining the viability and phenotype of myofibers under harsh environments. The hybrid hydrogel in-situ crosslinked with hiPSCs and EVs is facilely used to fabricate large-scale muscle constructs by the stacking of micro-patterned hydrogel domains. Later, we confirmed a combinational effect, whereby muscle tissue regeneration and functional restoration were improved, via an in vivo murine volumetric muscle loss model.
Biopsychosocial Impact of Multiple Sclerosis in Omani Patients: A Multicenter Comparative Study
(2024-10-22) Jeyaseelan, Lakshmanan
Background/Objectives: Multiple sclerosis (MS) is a chronic neurological disorder characterized by various clinical presentations and manifestations that include biopsychosocial impediments. This study has three interrelated goals relevant to biopsychosocial functioning: (i) compare reasoning ability, neuropsychological functioning, affective range, and quality of life (QoL) between people with multiple sclerosis (PwMS) and healthy controls; (ii) explore gender differences in reasoning ability and neuropsychological functioning, affective symptoms, and QoL among PwMS; and (iii) examine the relationship between QoL and cognitive performance in PwMS, focusing on those within adequate vs. adequate QoL.