MBRU Knowledge Repository
Knowledge Repository at Mohammed Bin Rashid University of Medicine and Health Sciences
Welcome to digital archive and research repository of Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU). MBRU Knowledge Repository is a digital service that collects, preserves, and distributes digital material. MBRU's scholarly communications including theses, faculty publications, student projects, and departmental records and publications are the key digital records available in this repository. Repositories are important tools for preserving an organization's legacy; they facilitate digital preservation and scholarly communication.
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Communities in DSpace
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- Library Digital Archives
- Research and Scholarly work of College of Medicine
- Dubai Health Researchers Profiles
- Research and Scholarly work of Graduate Medical Education
- Research and Scholarly work of Hamdan Bin Mohammed College of Dental Medicine
- Research and Scholarly work of Hind Bint Maktoum College of Nursing and Midwifery
- Research and Scholarly work of IoL
- Research publications of other departments
- Theses and dissertations submitted by MBRU graduate and post-graduate students.
Recent Submissions
Pseudomyxoma peritonei of appendiceal mucinous neoplasm origin: A case report and review of literature.
(2024-12) Mousa, Ahmed Hafez
Appendiceal mucinous neoplasms, a rarity comprising less than 1% of all cancers, present intricate challenges in clinical management, and their incidence is on the rise. Notably, these neoplasms tend to metastasize intraperitoneally, leading to peritoneal carcinomatosis and concurrent accumulation of mucinous material, resulting in pseudomyxoma peritonei. Due to its spectrum of presentation, the classification of the appendiceal mucinous neoplasms remains a controversial subject with a range of management from a simple appendicectomy to a complex hyperthermic intraperitoneal chemotherapy (HIPEC). A 42-year-old Chadian male presented to the hospital with a sudden onset of right lower abdominal pain radiating to the inguinal region for 24 hours, associated with nausea and vomiting. The abdomen was distended and ascitic. Laboratory investigations revealed anemia, leukocytosis, hypernatremia, hypokalemia, elevated ESR, high CEA marker, and normal CA19-9. An abdominopelvic CT with contrast demonstrated extensive ascites and cystic masses in the liver, and pancreas with soft tissue thickening of the cecum; however, the appendix is not well-delineated. Patient was managed with chemotherapy and HIPEC followed by removal of all the affected parts. Nodules of the peritoneum and liver were submitted for histopathological analysis and a final diagnosis of pseudomyxoma peritonei of primary appendicular origin was established. This case highlights a case of extensive pseudomyxoma peritonei of appendicular origin managed aggressively by HIPEC and multiple resections of the involved organs. Prognosis of such a case is determined by the grade of the appendiceal tumor and the extent of invasion.
Ischemic Optic Neuropathy: A Review of Current and Potential Future Pharmacotherapies.
(2024-09-27) Badla, Beshr Abdulaziz
The treatment of arteritic anterior ischemic optic neuropathy (AAION), non-arteritic ischemic optic neuropathy (NAAION), and posterior ischemic optic neuropathy (PION) is a topic of ongoing research with mixed evidence on some pharmacotherapies and a need for more consensus. This manuscript provides an overview of these conditions' current, potential future, and attempted pharmacotherapies. AAION's current treatment regimen consists of high-dose steroids, with methotrexate, tocilizumab, and abatacept, being the most viable steroid-sparing therapy candidates. As for NAAION, the treatments being tried are vast, with mixed evidence supporting each modality. Similarly, despite the various treatment options explored, there still needs to be a universally effective therapy for PION. More research is needed to formulate an agreed-upon treatment regimen for these conditions.
Chronic Inflammatory Markers in Overweight and Obese Children: A Cross-sectional Analytical Study
(2024) Kumar, Ramachandran R
Introduction: Childhood obesity is associated with chronic low-grade systemic inflammation, which results in obesity-related comorbidities. This study compared the inflammatory markers between obese and normal children and assessed obesity-related comorbidities.
Microbial laden mobile phones from international conference attendees pose potential risks to public health and biosecurity.
(2024-09-26) Senok, Abiola
Introduction: Mobile phones, contaminated with pathogenic microorganisms, have the potential to act as "trojan horses". The microbial signatures present on their surfaces most probably vary across different geographical regions. As a result, mobile phones belonging to international conference attendees may serve as a model for global microbial dissemination, posing potential risks to public health and biosecurity.
SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency
(2024) Tayoun, Ahmad Abou
Inherited deficiency of the RNA lariat-debranching enzyme 1 (DBR1) is a rare etiology of brainstem viral encephalitis. The cellular basis of disease and the range of viral predisposition are unclear. We report inherited DBR1 deficiency in a 14-year-old boy who suffered from isolated SARS-CoV-2 brainstem encephalitis. The patient is homozygous for a previously reported hypomorphic and pathogenic DBR1 variant (I120T). Consistently, DBR1 I120T/I120T fibroblasts from affected individuals from this and another unrelated kindred have similarly low levels of DBR1 protein and high levels of RNA lariats. DBR1 I120T/I120T human pluripotent stem cell (hPSC)-derived hindbrain neurons are highly susceptible to SARS-CoV-2 infection. Exogenous WT DBR1 expression in DBR1 I120T/I120T fibroblasts and hindbrain neurons rescued the RNA lariat accumulation phenotype. Moreover, expression of exogenous RNA lariats, mimicking DBR1 deficiency, increased the susceptibility of WT hindbrain neurons to SARS-CoV-2 infection. Inborn errors of DBR1 impair hindbrain neuron-intrinsic antiviral immunity, predisposing to viral infections of the brainstem, including that by SARS-CoV-2.