MBRU Knowledge Repository
Knowledge Repository at Mohammed Bin Rashid University of Medicine and Health Sciences
Welcome to digital archive and research repository of Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU). MBRU Knowledge Repository is a digital service that collects, preserves, and distributes digital material. MBRU's scholarly communications including theses, faculty publications, student projects, and departmental records and publications are the key digital records available in this repository. Repositories are important tools for preserving an organization's legacy; they facilitate digital preservation and scholarly communication.
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Communities in DSpace
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- Library Digital Archives
- Research and Scholarly work of College of Medicine
- Research and Scholarly work of College of Nursing and Midwifery
- Dubai Health Researchers Profiles
- Research and Scholarly work of Graduate Medical Education
- Research and Scholarly work of Hamdan Bin Mohammed College of Dental Medicine
- Research and Scholarly work of IoL
- Research publications of other departments
- Theses and dissertations submitted by MBRU graduate and post-graduate students.
Recent Submissions
Improving National and International Surveillance of Movement Behaviours in Childhood and Adolescence: An International Modified Delphi Study.
(2024-10-03) Loney, Tom
Background: The actions required to achieve higher-quality and harmonised global surveillance of child and adolescent movement behaviours (physical activity, sedentary behaviour including screen time, sleep) are unclear.
Targeting PAR2-mediated inflammation in osteoarthritis: a comprehensive in vitro evaluation of oleocanthal's potential as a functional food intervention for chondrocyte protection and anti-inflammatory effects.
(2024-10-01) Patnaik, Rajashree; Varghese, Riah; Jannati, Shirin; Naidoo, Nerissa; Banerjee, Yajnavalka
Background: Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by chronic inflammation and progressive cartilage degradation, ultimately leading to joint dysfunction and disability. Oleocanthal (OC), a bioactive phenolic compound derived from extra virgin olive oil, has garnered significant attention due to its potent anti-inflammatory properties, which are comparable to those of non-steroidal anti-inflammatory drugs (NSAIDs). This study pioneers the investigation into the effects of OC on the Protease-Activated Receptor-2 (PAR-2) mediated inflammatory pathway in OA, aiming to validate its efficacy as a functional food-based therapeutic intervention.
Triglyceride-glucose index (TyG) as a novel biomarker in the era of cardiometabolic medicine.
(2025-01-01) Rizzo, Manfredi
In the period of increasing prevalence of metabolic disorders such as obesity and diabetes, healthcare professionals are facing significant challenges. Therefore, an accurate global assessment of insulin resistance is of utmost importance. Current medical research is focused on identifying an easily accessible and reproducible gold-standard surrogate marker for insulin resistance. Ideally, such a marker would enable healthcare providers to predict the risk of type 2 diabetes and cardiovascular diseases. The triglyceride-glucose index (TyG) is a promising marker for preventive cardiology and cardiometabolic medicine. This narrative review article aims to provide a comprehensive evaluation of the credibility of TyG as a surrogate marker of insulin resistance among patients at different stages across the cardiometabolic continuum. This assessment fully complies with evidence-based medicine and offers valuable insight into the clinical utility of TyG.
Genomic insights from a deeply phenotyped highly consanguineous neurodevelopmental disorders cohort.
(2024-09-26) Mohamed, Nesrin; Satsangi, Dharana; Hanif, Shehzad; Tambi, Richa; Nassir, Nasna; Uddin, Mohammed
Purpose: The genetic underpinning of neurodevelopmental disorders (NDDs) in diverse ethnic populations, especially those with high rates of consanguinity, remains largely unexplored. Here, we aim to elucidate genomic insight from 576 well-phenotyped and highly consanguineous (16%) NDD cohort.
Pathogenic mechanisms, diagnostic, and therapeutic potential of microvesicles in diabetes and its complications.
(2024-11) Giordo, Roberta
Extracellular vesicles (EVs), particularly microvesicles (MVs), have gained significant attention for their role as mediators of intercellular communication in both physiological and pathological contexts, including diabetes mellitus (DM) and its complications. This review provides a comprehensive analysis of the emerging roles of MVs in the pathogenesis of diabetes and associated complications such as nephropathy, retinopathy, cardiomyopathy, and neuropathy. MVs, through their cargo of proteins, lipids, mRNAs, and miRNAs, regulate critical processes like inflammation, oxidative stress, immune responses, and tissue remodeling, all of which contribute to the progression of diabetes and its complications. We examine the molecular mechanisms underlying MVs' involvement in these pathological processes and discuss their potential as biomarkers and therapeutic tools, particularly for drug delivery. Despite promising evidence, challenges remain in isolating and characterizing MVs, understanding their molecular mechanisms, and validating them for clinical use. Advanced techniques such as single-cell RNA sequencing and proteomics are required to gain deeper insights. Improved isolation and purification methods are essential for translating MVs into clinical applications, with potential to develop novel diagnostic and therapeutic strategies to improve patient outcomes in diabetes.