Publication:
Genetic determinants of severe COVID 19 in young Asian and Middle Eastern patients: a case series

dc.contributor.authorBadla, Beshr Abdulaziz
dc.contributor.authorHanifa, Mohamed Samer
dc.contributor.authorAl Suwaidi, Hanan
dc.contributor.authorNowotny, Norbert
dc.contributor.authorPopatia, Rizwana
dc.contributor.authorAlsheikh-Ali, Alawi
dc.contributor.authorLoney, Tom
dc.contributor.authorTayoun, Ahmad Abou
dc.date.accessioned2024-03-27T08:12:07Z
dc.date.available2024-03-27T08:12:07Z
dc.date.issued2023
dc.description.abstractAbstract: Studies of genetic factors associated with severe COVID-19 in young adults have been limited in non-Caucasian populations. Here, we clinically characterize a case series of patients with COVID19, who were otherwise healthy, young adults (N= 55; mean age 34.1 ±SD 5.0 years) from 16 Asian, Middle Eastern, and North African countries. Using whole exome sequencing, we identify rare, likely deleterious variants afecting 16 immune-related genes in 17 out of 55 patients (31%), including 7 patients (41% of all carriers or 12.7% of all patients) who harbored multiple such variants mainly in interferon and toll-like receptor genes. Protein network analysis as well as transcriptomic analysis of nasopharyngeal swabs from an independent COVID-19 cohort (N= 50; 42% Asians and 22% Arabs) revealed that most of the altered genes, as identifed by whole exome sequencing, and the associated molecular pathways were signifcantly altered in COVID-19 patients. Genetic variants tended to be associated with mortality, intensive care admission, and ventilation support. Our clinical cases series, genomic and transcriptomic fndings suggest a possible role for interferon pathway genes in severe COVID-19 and highlight the importance of extending genetic studies to diverse populations to better understand the human genetics of disease.en_US
dc.identifier.other204-2023.167
dc.identifier.urihttps://repository.mbru.ac.ae/handle/1/1442
dc.language.isoenen_US
dc.subjectCOVID‑19en_US
dc.subjectYoungen_US
dc.subjectAsianen_US
dc.subjectMiddle Easternen_US
dc.subjectPatientsen_US
dc.titleGenetic determinants of severe COVID 19 in young Asian and Middle Eastern patients: a case seriesen_US
dc.typeArticleen_US
dspace.entity.typePublicationen_US

Files