Browsing by Author "Tayoun, Ahmad Abou"
Now showing items 1-20 of 21
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Association of Dromedary Camels and Camel Ticks with Reassortant Crimean-Congo Hemorrhagic Fever Virus, United Arab Emirates
Ramaswamy, Sathiskumar; Karuvantevida, Noushad; Tayoun, Ahmad Abou; Loney, Tom; Nowotny, Norbert (2021)Abstract: We previously detected a potentially novel reassortant of Crimean-Congo hemorrhagic fever virus in camels at the largest livestock market in the United Arab Emirates. A broader survey of large mammals at the ... -
Case Report: CMV-Associated Congenital Nephrotic Syndrome
Tayoun, Ahmad Abou (2020)Background: Congenital nephrotic syndrome, historically defined by the onset of large proteinuria during the first 3 months of life, is a rare clinical disorder, generally with poor outcome. It is caused by pathogenic ... -
Clinical evaluation and etiologic diagnosis of hearing loss: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG)
Tayoun, Ahmad Abou (2022-07)Abstract: Hearing loss is a common and complex condition that can occur at any age, can be inherited or acquired, and is associated with a remarkably wide array of etiologies. The diverse causes of hearing loss, combined ... -
Detection of copy number variants and genes by chromosomal microarray in an Emirati neurodevelopmental disorders cohort
Nassir, Nasna; Al Shaibani, Shaiban; Ahmed, Awab; Tayoun, Ahmad Abou; Uddin, Mohammed; Albanna, Ammar (2022)Abstract: Copy number variations (CNVs) are highly implicated in the etiology of neurodevelopmental disorders (NDDs), and chromosomal microarray analysis (CMA) has been recommended as a frst-tier test for many NDDs. We ... -
Diagnosing Cornelia de Lange syndrome and related neurodevelopmental disorders using RNA sequencing
Tayoun, Ahmad Abou (2020)Purpose: Neurodevelopmental disorders represent a frequent indication for clinical exome sequencing. Fifty percent of cases, however, remain undiagnosed even upon exome reanalysis. Here we show RNA sequencing (RNA-seq) ... -
Effect of Common Medications on the Expression of SARS-CoV-2 Entry Receptors in Kidney Tissue
Tayoun, Ahmad Abou; Loney, Tom; Uddin, Mohammed; Senok, Abiola; Al Heialy, Saba; Alsheikh-Ali, Alawi (2020)Abstract: Besides the respiratory system, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection was shown to affect other essential organs such as the kidneys. Early kidney involvement during the course ... -
Genetic and Clinical Characteristics of Patients in the Middle East With Multisystem Inflammatory Syndrome in Children
Uddin, Mohammed; Al Suwaidi, Hanan; Al-Hammadi, Suleiman; Loney, Tom; Nowotny, Norbert; Alsheikh-Ali, Alawi; Tayoun, Ahmad Abou (2022)Importance: Clinical, genetic, and laboratory characteristics of Middle Eastern patients with multisystem in‐ flammatory syndrome in children (MIS-C) have not yet been documented. Objective: To assess the genetic and ... -
The Genomic Landscape of Pediatric Rheumatology Disorders in the Middle East
Tayoun, Ahmad Abou (2020)Abstract: Genetic investigations for patients with pediatric rheumatological disorders have been limited to classic genotyping testing, mainly MEFV hotspot mutation analysis, for periodic fever. Therefore, the landscape ... -
Genotype-phenotype correlation identified a novel SARS-CoV-2 variant possibly linked to severe disease
Loney, Tom; Al Suwaidi, Hanan; Uddin, Mohammed; Senok, Abiola; Nowotny, Norbert; Alsheikh-Ali, Alawi; Tayoun, Ahmad Abou (2021)Abstract: The geographic location and heterogeneous multi-ethnic population of Dubai (United Arab Emirates; UAE) provide a unique setting to explore the global molecular epidemiology of SARS-CoV-2 and relationship between ... -
Host transcriptomic profiling of COVID-19 patients with mild, moderate, and severe clinical outcomes
Uddin, Mohammed; Loney, Tom; Nowotny, Norbert; Alsuwaidi, Hanan; Alsheikh-Ali, Alawi; Tayoun, Ahmad Abou (2021)Abstract: Characterizing key molecular and cellular pathways involved in COVID-19 is essential for disease prognosis and management. We perform shotgun transcriptome sequencing of human RNA obtained from nasopharyngeal ... -
MERS-CoV in sheep, goats, and cattle, United Arab Emirates, 2019: Virological and serological investigations reveal an accidental spillover from dromedaries
Loney, Tom; Tayoun, Ahmad Abou (2021)Abstract: The recent COVID-19 pandemic has demonstrated again the global threat posed by emerging zoonotic coronaviruses. During the past two decades alone, humans have experienced the emergence of several coronaviruses, ... -
Middle Eastern Genetic Variation Improves Clinical Annotation of the Human Genome
Tayoun, Ahmad Abou (2022)Abstract: Genetic variation in populations of Middle Eastern origin remains highly underrepresented in most comprehensive genomic databases. This underrepresentation hampers the functional annotation of the human genome ... -
Multiple early introductions of SARS‑CoV‑2 into a global travel hub in the Middle East
Tayoun, Ahmad Abou; Loney, Tom; Uddin, Mohammed; Senok, Abiola; Nowotny, Norbert; Alsheikh-Ali, Alawi; Al Suwaidi, Hanan (2020)Abstract: International travel played a significant role in the early global spread of SARS-CoV-2. Understanding transmission patterns from different regions of the world will further inform global dynamics of the pandemic. ... -
Regulation of Angiotensin- Converting Enzyme 2 in Obesity: Implications for COVID-19
Al Heialy, Saba; Hachim, Mahmood Yaseen; Senok, Abiola; Tayoun, Ahmad Abou; Alsheikh-Ali, Alawi (2020)Abstract: The ongoing COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Age, smoking, obesity, and chronic diseases such as cardiovascular disease and diabetes have been described as risk factors for severe ... -
SARS-CoV-2 Whole Genome Amplification and Sequencing for Effective Population-Based Surveillance and Control of Viral Transmission
Loney, Tom; Al Suwaidi, Hanan; Nowotny, Norbert; Alsheikh-Ali, Alawi; Tayoun, Ahmad Abou (2020)BACKGROUND: With the gradual reopening of economies and resumption of social life, robust surveillance mechanisms should be implemented to control the ongoing COVID-19 pandemic. Unlike RT-qPCR, SARSCoV- 2 whole genome ... -
SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?
Tayoun, Ahmad Abou (2021)Abstract: Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly ... -
A Simple Practical Guide to Genomic Diagnostics in a Pediatric Setting
Tayoun, Ahmad Abou (2021)Abstract: With limited access to trained clinical geneticists and/or genetic counselors in the majority of healthcare systems globally, and the expanding use of genetic testing in all specialties of medicine, many healthcare ... -
Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19
Nassir, Nasna; Tambi, Richa; Bankapur, Asma; Al Heialy, Saba; Karuvantevida, Noushad; Zehra, Binte; Begum, Ghausia; Hameid, Reem Abdel; Ahmed, Awab; Shabestari, Seyed Ali Safizadeh; Kandasamy, Richard K; Loney, Tom; Tayoun, Ahmad Abou; Nowotny, Norbert; Hachim, Mahmood Yaseen; Berdiev, Bakhrom; Alsheikh-Ali, Alawi; Uddin, Mohammed (2021)Summary: Understanding host cell heterogeneity is critical for unraveling disease mechanism. Utilizing large-scale single-cell transcriptomics, we analyzed multiple tissue specimens from patients with life-threatening ... -
Utility of clinical exome sequencing in a complex Emirati pediatric cohort
Uddin, Mohammed; Tayoun, Ahmad Abou (2020)Abstract: Clinical exome sequencing (CES) has become a routine diagnostic tool in several pediatric subspecialties, with a reported average diagnostic yield of ~25% in this patient poulation. The utility of CES in the ... -
Utility of droplet digital PCR and NGS-based CNV clinical assays in hearing loss diagnostics: current status and future prospects
Tayoun, Ahmad Abou (2021)Introduction: Genetic variants in over 100 genes can cause non-syndromic hearing loss (NSHL). Comprehensive diagnostic testing of these genes requires detecting pathogenic sequence and copy number alterations with economical, ...