Browsing by Author "Radhakrishnan, Rajan"
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Editorial: The use of plant metabolites to ameliorate sequelae of chemotherapy
Radhakrishnan, Rajan (2023)Introduction: Cancer continues to be a fatal disease with a high annual mortality rate, globally. Despite medical advancements, cancer treatments are often associated with significant adverse effects, posing a great ... -
The Effect of Statins on Male Reproductive Parameters: A Mechanism Involving Dysregulation of Gonadal Hormone Receptors and TRPV1
Omolaoye, Temidayo S.; Cyril, Asha Caroline; Radhakrishnan, Rajan; Rawat, Surendra Singh; Karuvantevida, Noushad; Du Plessis, Stefan (2023)Abstract: Statins have been shown to cause diverse male reproductive function impairment, and in some cases, orchialgia. Therefore, the current study investigated the possible mechanisms through which statins may alter ... -
Mechanisms of pain in sickle cell disease
Takaoka, Kensuke; Cyril, Asha Caroline; Radhakrishnan, Rajan (2020)Objectives: The hallmark of sickle cell disease (SCD) is acute and chronic pain, and the pain dominates the clinical characteristics of SCD patients. Although pharmacological treatments of SCD targeting the disease ... -
Natural compound catechol induces DNA damage, apoptosis, and G1 cell cycle arrest in breast cancer cells
Radhakrishnan, Rajan (2020)Abstract: Targeting cell cycle and inducing DNA damage by activating cell death pathways are considered as effective therapeutic strategy for combating breast cancer progression. Many of the naturally known small molecules ... -
Nigella sativa and its chemical constituents: pre clinical and clinical evidence for their potential anti SARS CoV 2 effects
Cyril, Asha Caroline; Ali, Najma Mohamed; Parambath, Anagha Nelliyulla; Jan, Reem Kais; Radhakrishnan, Rajan; Karuvantevida, Noushad; Aburamadan, Haneen (2023)Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over 500 million reported cases of COVID-19 worldwide with relatively high morbidity and mortality. Although global vaccination drive has ... -
Pain in chronic prostatitis and the role of ion channels: a brief overview
Cyril, Asha Caroline; Jan, Reem Kais; Radhakrishnan, Rajan (2021)Background: Prostatitis is the third most common urologic condition affecting more than half the male population at some point in their lives. There are different categories of prostatitis, of which approximately 90% of ... -
Role of flavonoids in thrombotic, cardiovascular, and inflammatory diseases
Radhakrishnan, Rajan (2017)Abstract: The failure of mechanisms of natural anti-coagulation either due to genetic impairment or due to severe external injuries may result in a condition called thrombosis. This is believed to be the primary cause for ... -
Statins and Male Fertility: Is There a Cause for Concern?
Omolaoye, Temidayo S.; Mubarak, Maitha; Cyril, Asha Caroline; Duvuru, Ruthwik; Radhakrishnan, Rajan; Du Plessis, Stefan (2022)Abstract: The well-known 3-hydroxyl 3-methyl glutaryl-Coenzyme A reductase inhibitors, called statins, have been the main medication used in the treatment of hypercholesterolemia and some cases of cardiovascular diseases. ...