Browsing by Author "Omolaoye, Temidayo S."
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Descriptive histomorphological evaluation of the testis and caudal epididymis following treatment with rooibos (Aspalathus linearis), honeybush (Cyclopia intermedia) and sutherlandia (Lessertia frutescens) in healthy and streptozotocininduced diabetic rats
Omolaoye, Temidayo S.; Plessis, Stefan S du (2021)Objective: To evaluate the testis and the cauda epididymis after treating both healthy and diabetic rats with rooibos (Aspalathus linearis), honeybush (Cyclopia intermedia), and sutherlandia (Lessertia frutescens), ... -
The effect of Aspalathin linearis, Cyclopia intermedia and Sutherlandia frutescene on sperm functional parameters of healthy male wistar rats
Omolaoye, Temidayo S.; Plessis, Stefan Du (2023)Introduction: Rooibos (Aspalathin linearis), honeybush (Cyclopia intermedia), and sutherlandia (Sutherlandia frutescene) are three Southern Africa indigenous plants, of which the extracts have become house-hold items and ... -
The Effect of Statins on Male Reproductive Parameters: A Mechanism Involving Dysregulation of Gonadal Hormone Receptors and TRPV1
Omolaoye, Temidayo S.; Cyril, Asha Caroline; Radhakrishnan, Rajan; Rawat, Surendra Singh; Karuvantevida, Noushad; Du Plessis, Stefan (2023)Abstract: Statins have been shown to cause diverse male reproductive function impairment, and in some cases, orchialgia. Therefore, the current study investigated the possible mechanisms through which statins may alter ... -
Mechanisms of SARS-CoV-2 and Male Infertility: Could Connexin and Pannexin Play a Role?
Omolaoye, Temidayo S.; Jalaleddine, Nour; Du Plessis, Stefan (2022)Abstract: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on male infertility has lately received significant attention. SARS-CoV-2, the virus that causes coronavirus disease (COVID-19) in humans, ... -
The mutagenic effect of tobacco smoke on male fertility
Omolaoye, Temidayo S.; Boillat, Thomas; Loney, Tom; Plessis, Stefan S du (2021)Abstract: Despite the association between tobacco use and the harmful effects on general health as well as male fertility parameters, smoking remains globally prevalent. The main content of tobacco smoke is nicotine and ... -
Omics and Male Infertility: Highlighting the Application of Transcriptomic Data
Omolaoye, Temidayo S.; Kandasamy, Richard K; Hachim, Mahmood Yaseen; Du Plessis, Stefan; Omolaoye, Victor A (2022)Abstract: Male infertility is a multifaceted disorder affecting approximately 50% of male partners in infertile couples. Over the years, male infertility has been diagnosed mainly through semen analysis, hormone evaluations, ... -
Oxidative Stress and Male Infertility: Evidence From a Research Perspective
Omolaoye, Temidayo S.; Plessis, Stefan S. du (2022)Abstract: Male fertility potential can be influenced by a variety of conditions that frequently coincide. Spermatozoa are particularly susceptible to oxidative damage due to their limited antioxidant capacity and cell ... -
Statins and Male Fertility: Is There a Cause for Concern?
Omolaoye, Temidayo S.; Mubarak, Maitha; Cyril, Asha Caroline; Duvuru, Ruthwik; Radhakrishnan, Rajan; Du Plessis, Stefan (2022)Abstract: The well-known 3-hydroxyl 3-methyl glutaryl-Coenzyme A reductase inhibitors, called statins, have been the main medication used in the treatment of hypercholesterolemia and some cases of cardiovascular diseases. ... -
Using publicly available transcriptomic data to identify mechanistic and diagnostic biomarkers in azoospermia and overall male infertility
Omolaoye, Temidayo S.; Hachim, Mahmood Yaseen; Du Plessis, Stefan (2022)Abstract Azoospermia, which is the absence of spermatozoa in an ejaculate occurring due to defects in sperm production, or the obstruction of the reproductive tract, afects about 1% of all men and is prevalent in up to ...