Browsing by Author "Giordo, Roberta"
Now showing items 1-13 of 13
-
Association between Paraoxonase/Arylesterase Activity of Serum PON-1 Enzyme and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
Giordo, Roberta (2022-11)Abstract: Background: A decrease in serum paraoxonase (PON-1) and arylesterase (ARE) activity has been reported in rheumatoid arthritis (RA) patients and linked to chronic inflammation and impaired antioxidant defense. ... -
Cytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells
Giordo, Roberta (2022)Abstract: Green chemistry is a useful tool for producing valuable chemicals from biomass. However, extracted compounds need to be tested for safety and efficacy before their use in humans. Here we investigate the chemical ... -
Disease-Associated Regulation of Non-Coding RNAs by Resveratrol: Molecular Insights and Therapeutic Applications
Giordo, Roberta (2022-07)Abstract: There have been significant advances, particularly over the last 20 years, in the identification of non-coding RNAs (ncRNAs) and their pathophysiological role in a wide range of disease states, particularly ... -
Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations
Giordo, Roberta (2023)Abstract: Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during pregnancy and throughout their lifespan. These outcomes lead to a perturbated in-utero environment ... -
Estrogen distinctly regulates transcription and translation of lncRNAs and pseudogenes in breast cancer cells
Giordo, Roberta; Lipovich, Leonard (2022-07)Abstract: Estrogen drives key transcriptional changes in breast cancer and stimulates breast cancer cells’ growth with multiple mechanisms to coordinate transcription and translation. In addition to protein-coding ... -
Iloprost Attenuates Oxidative Stress-Dependent Activation of Collagen Synthesis Induced by Sera from Scleroderma Patients in Human Pulmonary Microvascular Endothelial Cells
Giordo, Roberta (2021)Abstract: Endothelial cell injury is an early event in systemic sclerosis (SSc) pathogenesis and several studies indicate oxidative stress as the trigger of SSc-associated vasculopathy. Here, we show that circulating ... -
Implications and theragnostic potentials of circular RNAs in rheumatic diseases
Giordo, Roberta (2023)Abstract: Circular RNAs (circRNAs), a class of non-coding RNAs (ncRNAs), are highly stable and ubiquitous molecules that exhibit tissue-specific expression. Accumulating evidence has shown that aberrant expression of ... -
LncRNA-Associated Genetic Etiologies Are Shared between Type 2 Diabetes and Cancers in the UAE Population
Giordo, Roberta; Gulsha, Rida; Kalla, Sarah; Lipovich, Leonard (2022)Abstract: Numerous epidemiological studies place patients with T2D at a higher risk for cancer. Many risk factors, such as obesity, ageing, poor diet and low physical activity, are shared between T2D and cancer; however, ... -
NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs
Giordo, Roberta (2022)Abstract: Systemic sclerosis (SSc) is an immune disorder characterized by diffuse fibrosis and vascular abnormalities of the affected organs. Although the etiopathology of this disease is largely unknown, endothelial ... -
Nano-targeting vascular remodeling in cancer: Recent developments and future directions
Giordo, Roberta (2022)Abstract: Tumor growth and progression are strictly dependent on the adequate blood supply of oxygen and nutrients. The formation of new blood vessels and vascular networks is essential to ensure this demand. Blood vessels ... -
Non-coding regions of nuclear-DNA-encoded mitochondrial genes and intergenic sequences are targeted by autoantibodies in breast cancer
Giordo, Roberta; Lipovich, Leonard (2023)Introduction: Autoantibodies against mitochondrial-derived antigens play a key role in chronic tissue inflammation in autoimmune disorders and cancers. Here, we identify autoreactive nuclear genomic DNA (nDNA)-encoded ... -
Non-coding RNAs as biomarkers of myocardial infarction
Giordo, Roberta (2023)Abstract: Non-coding RNAs (ncRNAs) encompass a family of ubiquitous RNA molecules that lack protein-coding potential and have tissue-specific expression. A significant body of evidence indicates that ncRNA’s aberrant ... -
An updated overview of cyanidins for chemoprevention and cancer therapy
Giordo, Roberta (2023)Abstract: Anthocyanins are colored polyphenolic compounds that belong to the flavonoids family and are largely present in many vegetables and fruits. They have been used in traditional medicine in many cultures for a long ...