Browsing by Author "Du Plessis, Stefan"
Now showing items 1-20 of 20
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Computational Analysis of Short Linear Motifs in the Spike Protein of SARS-CoV-2 Variants Provides Possible Clues into the Immune Hijack and Evasion Mechanisms of Omicron Variant
(2022-08)Abstract: Short linear motifs (SLiMs) are short linear sequences that can mediate protein–protein interaction. Mimicking eukaryotic SLiMs to compete with extra- or intracellular binding partners, or to sequester host ... -
The Effect of Rooibos (Aspalathus linearis), Honeybush (Cyclopia intermedia) and Sutherlandia (Lessertia frutescens) on Testicular Insulin Signalling in Streptozotocin-Induced Diabetes in Wistar Rats
(2021)Background: Testicular insulin signalling is altered in diabetic (DM) males. While unravelling the mechanism through which DM exert these detrimental effects, studies have shown the importance of insulin regulation in ... -
The Effect of Statins on Male Reproductive Parameters: A Mechanism Involving Dysregulation of Gonadal Hormone Receptors and TRPV1
(2023)Abstract: Statins have been shown to cause diverse male reproductive function impairment, and in some cases, orchialgia. Therefore, the current study investigated the possible mechanisms through which statins may alter ... -
Effects of space flight on sperm function and integrity: A systematic review
(2022-08)Abstract: With the advancement in space exploration and the intention to establish an inhabitable human settlement on Mars, it is important to investigate the effects of exposure to space/microgravity and the associated ... -
Guinness World Record: Personal Experience and Physiological Responses of a Non-Professional Athlete Successfully Covering 620 Km in 7-Days by Foot Across the United Arab Emirates
(2022)Abstract: Ultra-endurance record-breaking attempts place significant metabolic, cardiovascular, and mechanical stress on the athlete. This research explores the personal experience and physiological responses of a ... -
Introducing the 4Ps Model of Transitioning to Distance Learning: A convergent mixed methods study conducted during the COVID-19 pandemic
(2021)Abstract: Significant concern has been raised regarding the effect of COVID-19 on medical education. This study aimed to shed light on the distance learning experiences of medical students and their instructors at the ... -
Mechanisms of SARS-CoV-2 and Male Infertility: Could Connexin and Pannexin Play a Role?
(2022)Abstract: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on male infertility has lately received significant attention. SARS-CoV-2, the virus that causes coronavirus disease (COVID-19) in humans, ... -
Mimicking Mother Nature in the Field of Human Reproduction?
(2023)Introduction: Although humans have made significant progress in understanding reproductive events, nature still has more information to reveal. Towards the end of the 19th century, humans started studying reproductive ... -
Monkeypox and Male Fertility: Is There Any Looming Danger?
(2022)Abstract: The current emergence of monkeypox virus infection, mainly reported from previously non-endemic regions, raised concerns about its transmission and possible implication on general health and wellbeing. The concern ... -
Omics and Male Infertility: Highlighting the Application of Transcriptomic Data
(2022)Abstract: Male infertility is a multifaceted disorder affecting approximately 50% of male partners in infertile couples. Over the years, male infertility has been diagnosed mainly through semen analysis, hormone evaluations, ... -
Re: The Impact of COVID-19 Vaccine on Sperm Quality
(2022)Experts summary: Owing to concerns about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on male fertility and the potential analogous effects of the coronavirus vaccine, Barda and colleagues ... -
SARS-CoV-2 and the testis: similarity with other viruses and routes of infection
(2020)Abstract: Since the start of the latest coronavirus (SARS-CoV-2) outbreak, the number of infected individuals and cases of coronavirus disease (COVID-19) has been increasing exponentially worldwide. Of interest is existing ... -
Semen and viruses: significance during the transmission of infections
(2022)Introduction: Viral infections may trigger significant public health problems, and semen can be considered a vital transmission route with potential evolutionary advantages. Xie et al. recently published a meta-analysis ... -
Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology
(2022)Abstract: Biomedical science is rapidly developing in terms of more transparency, openness and reproducibility of scientific publications. This is even more important for all studies that are based on results from basic ... -
Statins and Male Fertility: Is There a Cause for Concern?
(2022)Abstract: The well-known 3-hydroxyl 3-methyl glutaryl-Coenzyme A reductase inhibitors, called statins, have been the main medication used in the treatment of hypercholesterolemia and some cases of cardiovascular diseases. ... -
Strategies for malaria vaccination during the COVID-19 pandemic in African countries
(2022)Abstract: Since October 2021, the World Health Organization (WHO) recommends the use of RTS,S/AS01 (RTS,S) malaria vaccine for children in areas of moderate to high transmission of Plasmodium falciparum in Africa. The ... -
Taking a Leap of Faith:A Study of Abruptly Transitioning an Undergraduate Medical Education Program to Distance-Learning Owing to the COVID-19 Pandemic
(2021)Abstract: The COVID-19 pandemic has forced universities worldwide to immediately transition to distance-learning. Although numerous studies have investigated the effect of the COVID-19 pandemic on universities in the ... -
Testicular oxidative stress and apoptosis status in streptozotocin-induced diabetic rats after treatment with rooibos (Aspalathus linearis), honeybush (Cyclopia intermedia), and sutherlandia (Lessertia frutescens) infusions
(2021)Objective: To investigate the testicular oxidative stress and apoptosis status, as well as the sperm functional parameters in streptozotocin (STZ) induced diabetic rats following treatment with rooibos (Aspalathus ... -
The Uruguayan semen donor population: A twenty-eight-year retrospective study
(2019)Abstract: Several studies have reported a global decline in seminal quality over the years. The objective of this study was to describe the semen donor population of Uruguay through comparing data of successive samples ... -
Using publicly available transcriptomic data to identify mechanistic and diagnostic biomarkers in azoospermia and overall male infertility
(2022)Abstract Azoospermia, which is the absence of spermatozoa in an ejaculate occurring due to defects in sperm production, or the obstruction of the reproductive tract, afects about 1% of all men and is prevalent in up to ...