Browsing by Author "Uddin, Mohammed"
Now showing items 21-36 of 36
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Multiple early introductions of SARS‑CoV‑2 into a global travel hub in the Middle East
Tayoun, Ahmad Abou; Loney, Tom; Uddin, Mohammed; Senok, Abiola; Nowotny, Norbert; Alsheikh-Ali, Alawi; Al Suwaidi, Hanan (2020)Abstract: International travel played a significant role in the early global spread of SARS-CoV-2. Understanding transmission patterns from different regions of the world will further inform global dynamics of the pandemic. ... -
Mutational Landscape of Autism Spectrum Disorder Brain Tissue
Begum, Ghausia; Nassir, Nasna; Uddin, Mohammed (2022)Abstract: Rare post-zygotic mutations in the brain are now known to contribute to several neurodevelopmental disorders, including autism spectrum disorder (ASD). However, due to the limited availability of brain tissue, ... -
Mutations in RAB39B in individuals with intellectual disability, autism spectrum disorder, and macrocephaly
Uddin, Mohammed (2017-11-09)Background: Autism spectrum disorder (ASD), a developmental disorder of early childhood onset, affects males four times more frequently than females, suggesting a role for the sex chromosomes. In this study, we describe ... -
NeuroSCORE is a genome‑wide omics‑based model that identifes candidate disease genes of the central nervous system
Uddin, Mohammed (2022)Abstract: To identify candidate disease genes of central nervous system (CNS) phenotypes, we created the Neurogenetic Systematic Correlation of Omics-Related Evidence (NeuroSCORE). We identified five genome-wide metrics ... -
OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3 Microdeletion Syndrome
Uddin, Mohammed (2018-02-01)Abstract: Copy-number variations (CNVs) are strong risk factors for neurodevelopmental and psychiatric disorders. The 15q13.3 microdeletion syndrome region contains up to ten genes and is associated with numerous conditions, ... -
Publisher Correction: Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder
Uddin, Mohammed (2020)Publisher Correction: In the version of this article initially published, in Fig. 2a, zeros were omitted from the y-axis labels on the histogram. They should read, from bottom to top: 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, ... -
Rates, Distribution, and Implications of Post-zygotic Mosaic Mutations in Autism Spectrum Disorder
Uddin, Mohammed (2017-09)Abstract: We systematically analyzed post-zygotic mutations (PZMs) in whole-exome sequences from the largest collection of trios (5,947) with autism spectrum disorder (ASD) available, including 282 unpublished trios, and ... -
Reply to Eisenhut
Hameid, Reem Abdel; Uddin, Mohammed; Berdiev, Bakhrom (2021)Letter to the Editor: The Pathophysiology of COVID-19 and SARS-CoV-2 Infection -
SARS-CoV-2 may hijack GPCR signaling pathways to dysregulate lung ion and fluid transport
Hameid, Reem Abdel; Uddin, Mohammed; Berdiev, Bakhrom (2021)Abstract: The tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a virus responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic, toward the host cells is determined, at least in ... -
SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions
Uddin, Mohammed; Loney, Tom; Al Suwaidi, Hanan; Adrian, Thomas E; Nowotny, Norbert; Alsheikh-Ali, Alawi; Senok, Abiola C (2020)Abstract: The COVID-19 pandemic is due to infection caused by the novel SARS-CoV-2 virus that impacts the lower respiratory tract. The spectrum of symptoms ranges from asymptomatic infections to mild respiratory symptoms ... -
Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer
Uddin, Mohammed (2017-05-11)Abstract: Serum from one hundred and ten breast cancer patients and thirty healthy female volunteers, were prospectively collected and evaluated for serum levels of Shh and IL-6 using human Shh and IL-6 specific enzyme-linked ... -
Single-cell transcriptome identifes molecular subtype of autism spectrum disorder impacted by de novo loss-of-function variants regulating glial cells
Nassir, Nasna; Bankapur, Asma; Ali, Abdulrahman; Ahmed, Awab; Inuwa, Ibrahim M.; Shabestari, Seyed Ali Safzadeh; Albanna, Ammar; Berdiev, Bakhrom; Uddin, Mohammed (2021)Background: In recent years, several hundred autism spectrum disorder (ASD) implicated genes have been discov ered impacting a wide range of molecular pathways. However, the molecular underpinning of ASD, particularly ... -
Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19
Nassir, Nasna; Tambi, Richa; Bankapur, Asma; Al Heialy, Saba; Karuvantevida, Noushad; Zehra, Binte; Begum, Ghausia; Hameid, Reem Abdel; Ahmed, Awab; Shabestari, Seyed Ali Safizadeh; Kandasamy, Richard K; Loney, Tom; Tayoun, Ahmad Abou; Nowotny, Norbert; Hachim, Mahmood Yaseen; Berdiev, Bakhrom; Alsheikh-Ali, Alawi; Uddin, Mohammed (2021)Summary: Understanding host cell heterogeneity is critical for unraveling disease mechanism. Utilizing large-scale single-cell transcriptomics, we analyzed multiple tissue specimens from patients with life-threatening ... -
Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p
Uddin, Mohammed (2022-11)Abstract The canonical paradigm for converting genetic association to mechanism involves iteratively mapping individual associations to the proximal genes through which they act. In contrast, in the present study we ... -
Utility of clinical exome sequencing in a complex Emirati pediatric cohort
Uddin, Mohammed; Tayoun, Ahmad Abou (2020)Abstract: Clinical exome sequencing (CES) has become a routine diagnostic tool in several pediatric subspecialties, with a reported average diagnostic yield of ~25% in this patient poulation. The utility of CES in the ... -
Whole exome sequencing uncovered highly penetrant recessive mutations for a spectrum of rare genetic pediatric diseases in Bangladesh
Nassir, Nasna; Begum, Ghausia; Hameid, Reem Abdel; Berdeiv, Bakhrom K.; Uddin, Mohammed (2021)Abstract: Collectively, rare genetic diseases affect a significant number of individuals worldwide. In this study, we have conducted wholeexome sequencing (WES) and identified underlying pathogenic or likely pathogenic ...