MBRU Knowledge Repository: Recent submissions
Now showing items 721-740 of 1430
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Genomic medicine in the Middle East
(2021)Abstract: We discuss the current state of genomic medicine in Arab countries of the Middle East, a region with outsized contribution to Mendelian genetics due to inbreeding yet has poor representation in global variome ... -
The inflammatory biomarkers profile of hospitalized patients with COVID-19 and its association with patient’s outcome: A single centered study
(2021)Abstract: Several reports highlighted the central role of inflammation in the pathogenesis of corona virus disease-19 (COVID-19) disease. Also, the hyper-inflammatory response that is triggered by severe acute respiratory ... -
What is the effect of preterm birth on permanent tooth crown dimensions? A systematic review and meta-analysis
(2021)Background: The permanent tooth formation process may be disrupted in preterm infants with potential discrepancies in size and subsequent occlusal disturbances. Objective: To systematically analyse and quantitively ... -
Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study.
(2021)Objective: To evaluate the association of a prolonged corrected QT (QTc) interval in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its association with in-patient mortality. Methods: A ... -
Case Report: Reactive Lymphohistiocytic Proliferation in Infant With a Novel Nonsense Variant of IL2RG Who Received BCG Vaccine
(2021)Abstract: We present here a male young infant with X-linked severe combined immunodeficiency (MIM#300400) due to the novel nonsense variant of IL2RG (interleukin 2 receptor, gamma; MIM#308380), NM_000206.2(IL2RG):c.820_823dup ... -
Protocol for a Systematic Review on the Effectiveness of Interventions to Reduce Exposure to Occupational Solar UltraViolet Radiation (UVR) Among Outdoor Workers
(2021)Background: Solar UltraViolet Radiation (UVR) is considered the most relevant occupational carcinogenic exposure in terms of the number of workers exposed (i.e., outdoor workers) and UVR-induced skin cancers are among ... -
Proportional Changes in Cognitive Subdomains During Normal Brain Aging
(2021)Background: Neuroscience lacks a reliable method of screening the early stages of dementia. Objective: To improve the diagnostics of age-related cognitive functions by developing insight into the proportionality of ... -
Gestational Age Dependence of the Maternal Circulating Long Non-Coding RNA Transcriptome During Normal Pregnancy Highlights Antisense and Pseudogene Transcripts
(2021)Abstract: In the post-genomic era, our understanding of the molecular regulators of physiologic and pathologic processes in pregnancy is expanding at the whole-genome level. Longitudinal changes in the known protein-coding ... -
Telehealth to the Rescue During COVID-19: A Convergent Mixed Methods Study Investigating Patients' Perception.
(2021)Background: The onset of the pandemic necessitated abrupt transition to telehealth consultations. Although there is a few tools that gauge the patients' perception about their experiences, none of them are contextualized ... -
Estimate of the HOMA-IR Cut-off Value for Identifying Subjects at Risk of Insulin Resistance Using a Machine Learning Approach
(2021)Objectives: This study describes an unsupervised machine learning approach used to estimate the homeostatic model assessment-insulin resistance (HOMA-IR) cut-off for identifying subjects at risk of IR in a given ethnic ... -
The Restoration of Severe Generalized Dental Erosive Wear using Direct Composite: A Case Report
(2021)Introduction: This case report describes a conservative restorative approach in the management of severe generalized tooth wear. Case report: The male, aged 57 years, was mainly concerned with the poor appearance of ... -
The effect of layered double hydroxide on fluoride release and recharge from a commercial and an experimental resin varnish
(2021)Objectives: Layered Double Hydroxide (LDH) is capable of fluoride anion exchange and release. This study investigated the effects of incorporating ZnAl-LDH in commercial and experimental dental varnishes, on fluoride ... -
Immediate Postoperative Treatment of Keloids with Intraoperative Radiation Therapy Technology: A Pilot Study
(2021)Background: The combination of surgery and postoperative radiotherapy allows for the most effective results with keloids. In this trial, surgery and intraoperative radiation therapy (IORT) technology were used—the ... -
A modular map of Bradykinin‑mediated inflammatory signaling network
(2021)Abstract: Bradykinin, a member of the kallikrein-kinin system (KKS), is associated with an inflammatory response pathway with diverse vascular permeability functions, including thrombosis and blood coagulation. In majority, ... -
Sociodemographic determinants of prepregnancy body mass index and gestational weight gain: The Mutaba'ah study
(2021)Objective: This study examined the associations of sociodemographic and lifestyle factors with prepregnancy body mass index (BMI) and gestational weight gain (GWG). Methods: In the Mutaba'ah Study in the United Arab ... -
Burden, Treatment Patterns and Unmet Needs of Osteoarthritis in Dubai: a Retrospective Analysis of the Dubai Real-World Claims Database
(2021)Introduction: Osteoarthritis (OA) is a degenerative joint disease that impacts 3.3–3.6% of population globally with significant health and societal impact. The current study assessed the disease burden, treatment patterns, ... -
Evaluating the impact of in silico predictors on clinical variant classification
(2021)Background: In silico evidence is important to consider when interpreting genetic variants. According to the ACMG/AMP, in silico evidence is applied at the supporting strength level using the PP3 and BP4 criteria, for ... -
Mobile device use among emergency department healthcare professionals: prevalence, utilization and attitudes
(2021)Abstract: Mobile devices are increasingly permeating healthcare and are being regularly used by healthcare providers. We examined the prevalence and frequency of mobile device use, and perceptions around clinical and ... -
Whole exome sequencing uncovered highly penetrant recessive mutations for a spectrum of rare genetic pediatric diseases in Bangladesh
(2021)Abstract: Collectively, rare genetic diseases affect a significant number of individuals worldwide. In this study, we have conducted wholeexome sequencing (WES) and identified underlying pathogenic or likely pathogenic ... -
Prevalence of schistosomiasis and its association with anemia among pregnant women: a systematic review and meta-analysis
(2021)Background: Schistosomiasis is a highly prevalent parasitic disease that can lead to adverse maternal and perina tal outcomes. To our knowledge, there has been no systematic review and meta-analysis of schistosomiasis ...