Browsing Faculty Publications (CoM) by Author "Lipovich, Leonard"
Now showing items 1-11 of 11
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Activity-Dependent Non-Coding RNA MAPK Interactome of the Human Epileptic Brain
Lipovich, Leonard (2023)Abstract: The human brain has evolved to have extraordinary capabilities, enabling complex behaviors. The uniqueness of the human brain is increasingly posited to be due in part to the functions of primate-specific, ... -
Association of the ADIPOQ-AS LncRNA polymorphism rs2241766 with obesity: A Meta-analysis
Lipovich, Leonard (2022)Abstract: Adipose tissue secretes different hormones to orchestrate lipid and glucose metabolism and insulin function. Adiponectin a key signaling peptide, is encoded by ADIPOQ gene and secreted by white adipose tissue. ... -
A collective statement in support of saving pangolins
Lipovich, Leonard (2022)Letter to the Editor: We are an international group of biological scientists, conservationists, and environmentalists who have been closely following the plight and conservation of pangolins over a number of years. Pangolins ... -
Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis
Ibragimova, Shakhzada; Ramachandran, Revathy; Ali, Fahad R; Lipovich, Leonard; Ho, Samuel B (2021)Abstract: The recent increases in cancer incidences have been linked to lifestyle changes that result in obesity and metabolic syndrome. It is now evident that these trends are associated with the profound changes that ... -
Estrogen distinctly regulates transcription and translation of lncRNAs and pseudogenes in breast cancer cells
Giordo, Roberta; Lipovich, Leonard (2022-07)Abstract: Estrogen drives key transcriptional changes in breast cancer and stimulates breast cancer cells’ growth with multiple mechanisms to coordinate transcription and translation. In addition to protein-coding ... -
Gestational Age Dependence of the Maternal Circulating Long Non-Coding RNA Transcriptome During Normal Pregnancy Highlights Antisense and Pseudogene Transcripts
Lipovich, Leonard (2021)Abstract: In the post-genomic era, our understanding of the molecular regulators of physiologic and pathologic processes in pregnancy is expanding at the whole-genome level. Longitudinal changes in the known protein-coding ... -
LncRNA-Associated Genetic Etiologies Are Shared between Type 2 Diabetes and Cancers in the UAE Population
Giordo, Roberta; Gulsha, Rida; Kalla, Sarah; Lipovich, Leonard (2022)Abstract: Numerous epidemiological studies place patients with T2D at a higher risk for cancer. Many risk factors, such as obesity, ageing, poor diet and low physical activity, are shared between T2D and cancer; however, ... -
miRCOVID-19: Potential Targets of Human miRNAs in SARS-CoV-2 for RNA-Based Drug Discovery
Lipovich, Leonard (2021)Abstract: Sense-antisense interactions of long and short RNAs in human cells are integral to posttranscriptional gene regulation, in particular that of mRNAs by microRNAs. Many viruses, including severe acute respiratory ... -
Non-coding regions of nuclear-DNA-encoded mitochondrial genes and intergenic sequences are targeted by autoantibodies in breast cancer
Giordo, Roberta; Lipovich, Leonard (2023)Introduction: Autoantibodies against mitochondrial-derived antigens play a key role in chronic tissue inflammation in autoimmune disorders and cancers. Here, we identify autoreactive nuclear genomic DNA (nDNA)-encoded ... -
The Role of Genetic Variants in the Long Non-Coding RNA Genes MALAT1 and H19 in the Pathogenesis of Childhood Obesity
Lipovich, Leonard (2023)Abstract: Long non-coding RNAs (lncRNAs) play important roles in the maintenance of metabolic homeostasis. Recently, many studies have suggested that lncRNAs, such as Metastasis Associated Lung Adenocarcinoma Transcript ... -
YY1 directly interacts with myocardin to repress the triad myocardin/SRF/CArG box‑mediated smooth muscle gene transcription during smooth muscle phenotypic modulation
Lipovich, Leonard (2020)Summary : Yang 1 (YY1) regulates gene transcription in a variety of biological processes. In this study, we aim to determine the role of YY1 in vascular smooth muscle cell (VSMC) phenotypic modulation both in vivo and ...