Browsing Faculty Publications (CoM) by Author "Hachim, Mahmood Y."
Now showing items 1-11 of 11
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Clinical and Laboratory Profile of Hospitalized Symptomatic COVID-19 Patients: Case Series Study From the First COVID-19 Center in the UAE
Hachim, Mahmood Y.; Hannawi, Haifa (2021)Introduction: COVID-19 is raising with a second wave threatening many countries. Therefore, it is important to understand COVID-19 characteristics across different countries. Methods: This is a cross-sectional descriptive ... -
Coinfections in Patients Hospitalized with COVID-19: A Descriptive Study from the United Arab Emirates
Senok, Abiola; Nassar, Rania; Hachim, Mahmood Y.; Al Suwaidi, Hanan; Alsheikh-Ali, Alawi A. (2021)Purpose: Microbial coinfections in COVID-19 patients carry a risk of poor outcomes. This study aimed to characterize the clinical and microbiological profiles of coinfections in patients with COVID-19. Methods: A ... -
Differential expression of pyruvate dehydrogenase E1A and its inactive phosphorylated form among breast cancer subtypes
Hachim, Mahmood Y. (2021)Aims: Pyruvate dehydrogenase E1A (PDH-E1A) is one of the key regulators of metabolic pathways that determines pyruvate entry into the citric acid cycle or glycolysis. When PDH-E1A is phosphorylated (P-PDH-E1A), it loses ... -
Enhanced mitophagy in bronchial fibroblasts from severe asthmatic patients
Hachim, Mahmood Y. (2020)Background: Sub-epithelial fibrosis is a characteristic feature of airway remodeling in asthma which correlates with disease severity. Current asthma medications are ineffective in treating fibrosis. In this study, we ... -
Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic β-cells
Hachim, Mahmood Y. (2021)Abstract: Iron overload promotes the generation of reactive oxygen species (ROS). Pancreatic β-cells can counter oxidative stress through multiple anti-oxidant responses. Herein, RNA-sequencing was used to describe the ... -
Identification of Predictive Biomarkers for Lymph Node Involvement in Obese Women With Endometrial Cancer
Hachim, Mahmood Y. (2021)Abstract: Obesity, an established risk factor for endometrial cancer (EC), is also associated to increased risks of intraoperative and postoperative complications. A reliable tool to identify patients at low risk for lymph ... -
IL-13 Augments Histone Demethylase JMJD2B/KDM4B Expression Levels, Activity, and Nuclear Translocation in Airway Fibroblasts in Asthma
Hachim, Mahmood Y. (2021)Purpose: Asthma is one of the most common obstructive pulmonary diseases worldwide. Epigenetic alterations, including DNA methylation and histone modifications, have been reported to contribute to asthma pathogenesis. ... -
The impact of CBP expression in estrogen receptor-positive breast cancer
Hachim, Mahmood Y. (2021)Background: The development of new biomarkers with diagnostic, prognostic and therapeutic prominence will greatly enhance the management of breast cancer (BC). Several reports suggest the involvement of the histone ... -
Kidney Dysfunction among COVID-19 Patients in the United Arab Emirates
Hachim, Mahmood Y. (2021)Objectives: We sought to determine the estimated glomerular filtration rate (eGFR) among patients with COVID-19 and to examine its correlation with different demographic, clinical, and laboratory characteristics. ... -
The Molecular Basis of Gender Variations in Mortality Rates Associated With the Novel Coronavirus (COVID-19) Outbreak
Hachim, Mahmood Y. (2021)Abstract: Since the outbreak of the novel coronavirus disease (COVID-19) at the end of 2019, the clinical presentation of the disease showed a great heterogeneity with a diverse impact among different subpopulations. ... -
Molecular Examination of Differentially Expressed Genes in the Brains of Experimental Autoimmune Encephalomyelitis Mice Post Herceptin Treatment
Hachim, Mahmood Y. (2021)Objective: Herceptin (trastuzumab) is an approved drug for treating HER2+ breast cancer patients, but its use for other diseases is not established. We sought to investigate the effects of Herceptin on ameliorating ...