Browsing Faculty Publications (CoM) by Author "Alqassim, Saif S"
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Functional Mimicry of Eukaryotic Actin Assembly by Pathogen Effector Proteins
Alqassim, Saif S (2022)Abstract: The actin cytoskeleton lies at the heart of many essential cellular processes. There are hundreds of proteins that cells use to control the size and shape of actin cytoskeletal networks. As such, various pathogens ... -
Rickettsia Sca2 Recruits Two Actin Subunits for Nucleation but Lacks WH2 Domains.
Alqassim, Saif S (2019-02-05)Abstract: The Rickettsia 1800-amino-acid auto transporter protein surface cell antigen 2 (Sca2) promotes actin polymerization on the surface of the bacterium to drive its movement using an actin comet-tail mechanism. Sca2 ... -
Single particle cryo-EM analysis of Rickettsia conorii Sca2 reveals a formin-like core
Alqassim, Saif S (2023)Abstract: Spotted fever group Rickettsia undergo actin-based motility inside infected eukaryotic cells using Sca2 (surface cell antigen 2): an ~ 1800 amino-acid monomeric autotransporter protein that is surface-attached ... -
A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner
Alqassim, Saif S (2020)Abstract: Cytoplasmic dynein-1 (dynein) is the motor responsible for most retrograde transport of cargoes along microtubules in eukaryotic cells, including organelles, mRNA and viruses. Cargo selectivity and activation ...