Browsing by Author "Nowotny, Norbert"
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Genetic and Clinical Characteristics of Patients in the Middle East With Multisystem Inflammatory Syndrome in Children
Uddin, Mohammed; Al Suwaidi, Hanan; Al-Hammadi, Suleiman; Loney, Tom; Nowotny, Norbert; Alsheikh-Ali, Alawi; Tayoun, Ahmad Abou (2022)Importance: Clinical, genetic, and laboratory characteristics of Middle Eastern patients with multisystem in‐ flammatory syndrome in children (MIS-C) have not yet been documented. Objective: To assess the genetic and ... -
Genetic determinants of severe COVID 19 in young Asian and Middle Eastern patients: a case series
Badla, Beshr Abdulaziz; Hanifa, Mohamed Samer; Al Suwaidi, Hanan; Nowotny, Norbert; Popatia, Rizwana; Alsheikh-Ali, Alawi; Loney, Tom; Tayoun, Ahmad Abou (2023)Abstract: Studies of genetic factors associated with severe COVID-19 in young adults have been limited in non-Caucasian populations. Here, we clinically characterize a case series of patients with COVID19, who were otherwise ... -
Genotype-phenotype correlation identified a novel SARS-CoV-2 variant possibly linked to severe disease
Loney, Tom; Al Suwaidi, Hanan; Uddin, Mohammed; Senok, Abiola; Nowotny, Norbert; Alsheikh-Ali, Alawi; Tayoun, Ahmad Abou (2021)Abstract: The geographic location and heterogeneous multi-ethnic population of Dubai (United Arab Emirates; UAE) provide a unique setting to explore the global molecular epidemiology of SARS-CoV-2 and relationship between ... -
Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020
Tayoun, Ahmad N Abou; Alsheikh-Ali, Alawi; Loney, Tom; Nowotny, Norbert (2020)Abstract: We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three ... -
Haemosporidioses in wild Eurasian blackbirds (Turdus merula) and song thrushes (T. philomelos): an in situ hybridization study with emphasis on exo‑erythrocytic parasite burden
Nowotny, Norbert (2020)Background: Passerine birds are frequently infected with diverse haemosporidian parasites. While infections are traditionally considered benign in wild birds, recent studies demonstrated mortalities of passerine species ... -
Host transcriptomic profiling of COVID-19 patients with mild, moderate, and severe clinical outcomes
Uddin, Mohammed; Loney, Tom; Nowotny, Norbert; Alsuwaidi, Hanan; Alsheikh-Ali, Alawi; Tayoun, Ahmad Abou (2021)Abstract: Characterizing key molecular and cellular pathways involved in COVID-19 is essential for disease prognosis and management. We perform shotgun transcriptome sequencing of human RNA obtained from nasopharyngeal ... -
ICTV Virus Taxonomy Profile: Bornaviridae
Nowotny, Norbert (2021)Abstract: Members of the family Bornaviridae produce enveloped virions containing a linear negative-sense non-segmented RNA genome of about 9 kb. Bornaviruses are found in mammals, birds, reptiles and fish. The most-studied ... -
Increase in human West Nile and Usutu virus infections, Austria, 2018
Nowotny, Norbert (2018-10-25)Abstract: Between 28 June and 17 September 2018, 27 cases of human West Nile virus infections were recorded in Austria; four cases of West Nile neuroinvasive disease, 11 cases of West Nile fever, ... -
Infections of horses and shrews with Bornaviruses in Upper Austria: a novel endemic area of Borna disease
Nowotny, Norbert (2017-06-21)Borna disease, a lethal infection with Borna disease virus-1 (BoDV-1), was diagnosed in four horses from Upper Austria in 2015 and 2016. All cases occurred in winter (two cases in February 2015 and two cases in December ... -
Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries
Loney, Tom; Nowotny, Norbert (2021)Abstract: The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). ... -
Integrated analysis of human-animal-vector surveillance: West Nile virus infections in Austria, 2015–2016
Nowotny, Norbert (2018-03-14)Abstract: The results of integrated human and veterinary surveillance for West Nile virus (WNV) infections in Austria during the transmission seasons 2015 and 2016 are shown. Altogether WNV nucleic acid was detected in ... -
The knowns and unknowns of West Nile virus in Europe: what did we learn from the 2018 outbreak?
Nowotny, Norbert (2020)Introduction: West Nile virus (WNV) is a mosquito-borne human and animal pathogen with nearly worldwide distribution. In Europe, the virus is endemic with seasonal regional outbreaks that have increased in frequency over ... -
Maintenance of neutralizing antibodies over ten months in convalescent SARS-CoV-2 afflicted patients
Loney, Tom; Nowotny, Norbert (2021)Abstract Knowledge of the level and duration of protective immunity against SARS-CoV-2 after primary infection is of crucial importance for preventive approaches. Currently, there is a lack of evidence on the persistence ... -
MERS-CoV Found in Hyalomma dromedarii Ticks Attached to Dromedary Camels at a Livestock Market, United Arab Emirates, 2019
Loney, Tom; Mazrooei, Hessa; Karuvantevida, Noushad; Tayoun, Ahmad Abou; Alsheikh-Ali, Alawi; Nowotny, Norbert (2023)Abstract: The main mode of transmission of Middle East respiratory syndrome-related coronavirus (MERS-CoV) between dromedaries is likely via the respiratory route. However, there must be other modes to explain how the ... -
Modelling West Nile Virus and Usutu Virus Pathogenicity in Human Neural Stem Cells
Nowotny, Norbert (2020)Abstract: West Nile virus (WNV) and Usutu virus (USUV) are genetically related neurotropic mosquito-borne flaviviruses, which frequently co-circulate in nature. Despite USUV seeming to be less pathogenic for humans than ... -
Monitoring Urban Zoonotic Virus Activity: Are City Rats a Promising Surveillance Tool for Emerging Viruses?
Nowotny, Norbert (2022)Abstract: Urban environments represent unique ecosystems where dense human populations may come into contact with wildlife species, some of which are established or potential reservoirs for zoonotic pathogens that cause ... -
Mosquito biodiversity and mosquito-borne viruses in the United Arab Emirates
Karuvantevida, Noushad; Nowotny, Norbert (2019-04-03)Background: In the last 50 years, the United Arab Emirates (UAE) has experienced rapid population growth and urbanization. Urbanization is known to influence biodiversity, and there appears to be a link between the emergence ... -
Multiple early introductions of SARS‑CoV‑2 into a global travel hub in the Middle East
Tayoun, Ahmad Abou; Loney, Tom; Uddin, Mohammed; Senok, Abiola; Nowotny, Norbert; Alsheikh-Ali, Alawi; Al Suwaidi, Hanan (2020)Abstract: International travel played a significant role in the early global spread of SARS-CoV-2. Understanding transmission patterns from different regions of the world will further inform global dynamics of the pandemic. ... -
Mystery of fatal ‘staggering disease’ unravelled: novel rustrela virus causes severe meningoencephalomyelitis in domestic cats
Nowotny, Norbert (2023)Introduction: ‘Staggering disease’ is a neurological disease entity considered a threat to European domestic cats (Felis catus) for almost five decades. However, its aetiology has remained obscure. Rustrela virus (RusV), ... -
New World camelids are sentinels for the presence of Borna disease virus
Nowotny, Norbert (2021)Abstract: Borna disease (BD), a frequently fatal neurologic disorder caused by Borna disease virus 1 (BoDV-1), has been observed for decades in horses, sheep, and other mammals in certain regions of Europe. The bicoloured ...